Depression, Anxiety and Sleep in Parkinson's Disease

NCT07622303 | Not Yet Recruiting

• 1 other identifier: Soh-Med-26-5-4MS
• Study Type: observational
• Target: 100
• Locations: 0 countries
• Sites: N/A

Brief Summary

This study aims to assess the prevalence and severity of depression, anxiety, and sleep disorders among patients with idiopathic Parkinson's disease. The study will evaluate the relationship between neuropsychiatric symptoms and disease characteristics in order to improve early recognition and patient quality of life.

Conditions

Parkinson's Disease

Outcome Measures

Primary Outcomes (3)

• Assessment of Depression Severity in Patients with idiopathic Parkinson's Disease

  Depression severity measured using the Hamilton Depression Rating Scale (HAM-D). Scores range from 0 to 52, with higher scores indicating more severe depression.

  Baseline assessment during study enrollment.

• Assessment of Anxiety Severity in Patients with idiopathic Parkinson's Disease

  Anxiety severity measured using the Hamilton Anxiety Rating Scale (HAM-A). Scores range from 0 to 56, with higher scores indicating more severe anxiety.

  Baseline

• Assessment of Sleep Disturbance in Patients with idiopathic Parkinson's Disease

  Sleep disturbance measured using the Parkinson's Disease Sleep Scale (PDSS). Higher scores indicate better sleep quality and fewer sleep-related symptoms.

  Baseline

Eligibility Criteria

• Age: 50 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adult patients aged 50 years and older with idiopathic Parkinson's disease attending the Neurology Outpatient Clinic and/or admitted to the Neurology Department of Sohag University Hospital. A total of 100 eligible patients will be recruited to assess depression, anxiety, and sleep disorders.

You may qualify if:

• Patients diagnosed with idiopathic Parkinson's disease according to the Movement Disorder Society Clinical Diagnostic Criteria for Parkinson's Disease (Postuma et al., 2015).
• Age ≥ 50 years.
• Ability to understand and respond to questionnaires and rating scales.
• Ability and willingness to provide informed consent.

You may not qualify if:

• Patients with atypical parkinsonism.
• Patients with a history of other major neurological disorders (e.g., stroke, Alzheimer's disease, multiple sclerosis).
• Patients with severe cognitive impairment or dementia that prevents reliable completion of rating scales.
• Patients with a current diagnosis of severe psychiatric disorders unrelated to 5-Parkinson's disease (e.g., schizophrenia, bipolar disorder).
• Patients with unstable medical conditions. 7-Patients unable or unwilling to provide informed consent.

Sponsors & Collaborators

• Sohag University: lead

MeSH Terms

Conditions

Parkinson Disease

Condition Hierarchy (Ancestors)

Parkinsonian Disorders; Basal Ganglia Diseases; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Movement Disorders; Synucleinopathies; Neurodegenerative Diseases

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Neurology Resident

Study Record Dates

• First Submitted: May 24, 2026
• First Posted: June 3, 2026
• Study Start: June 1, 2026
• Primary Completion (Estimated): February 28, 2027
• Study Completion (Estimated): May 31, 2027
• Last Updated: June 9, 2026

Record last verified: 2026-05