Motion Sickness Severity and Sensorimotor Performance

NCT07619469 | Not Yet Recruiting

• 1 other identifier: 25
• Study Type: observational
• Target: 41
• Locations: 0 countries
• Sites: N/A

Brief Summary

Background: Motion sickness (MS) is a common syndrome characterized by autonomic and behavioral symptoms, such as nausea and dizziness, resulting from exposure to motion stimuli. Its pathophysiology is closely linked to sensory conflict and postural instability theories. While previous studies suggest that postural control, proprioception, and reaction times are affected in individuals susceptible to MS, there is a lack of comprehensive, comparative research evaluating all these parameters concurrently within the same cohort using standardized methods. Objective: This study aims to systematically measure balance, proprioceptive sensitivity, coordination, and reaction time parameters, and quantitatively analyze their relationship with motion sickness severity. Methodology: In this prospective, cross-sectional study, at least 41 participants aged 18-40 with motion sickness will be recruited. Participants will undergo motion sickness susceptibility and severity grading using the Motion Sickness Susceptibility Questionnaire Short Form (MSSQ-SF) and the Graybiel Scale. Objective assessments will include static and dynamic balance testing (ProKin®), knee joint position sense (Clinometer app), manual dexterity and dynamic balance coordination (Nine-Hole Peg Test, Tandem Walk, Romberg Test), and upper/lower extremity reaction time measurements (BlazePod system).

Conditions

Motion Sickness; Somatosensory Disorders; Dizziness

Outcome Measures

Primary Outcomes (3)

• Motion Sickness Severity (Graybiel Score)

  Used to grade the clinical severity of acute motion sickness symptoms (including nausea, cold sweating, increased salivation, and dizziness) following a randomized chair-rotation provocation protocol. 0 (Minimum) to 50 points (Maximum). Higher scores indicate greater symptom severity, representing a worse clinical outcome (scores of 16 or above designate frank sickness).

  1 hour

• Static Balance

  Evaluated objectively using the ProKin® computerized balance system. Participants stand on the platform under conditions: double-leg with eyes open.

  1 hour

• Dynamic Balance Performance

  Evaluated using the ProKin® system.

  1 hour

Secondary Outcomes (4)

• Knee Joint Proprioception

  1 hour

• Nine-Hole Peg Test (9HPT) Completion Time

  1 hour

• Tandem Walk Test Error Count

  1 hour

• Visual Reaction Time

  1 hour

Interventions

Standardized Sensorimotor Assessment and Motion Sickness Provocation Protocol OTHER

Participants will undergo a standardized battery of sensorimotor assessments, including static/dynamic balance tracking, knee joint position sense testing, manual dexterity/coordination tasks, and upper/lower extremity reaction time measurements, alongside a controlled motion sickness provocation session using a randomized chair-rotation protocol."

Eligibility Criteria

• Age: 18 Years - 40 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

The study population consists of adult individuals aged between 18 and 40 years who exhibit susceptibility to motion sickness.

You may qualify if:

• Individuals aged between 18 and 40 years.
• Diagnosed with motion sickness according to the Motion Sickness -Susceptibility Questionnaire Short Form (MSSQ-SF).
• Normal hearing acuity.
• No history of acute or chronic vestibular disease, other than motion sickness.
• Normal or corrected-to-normal vision.
• Adequate physical capability to fully perform the measurement protocols, including balance, proprioception, coordination, and reaction time tests.

You may not qualify if:

• Presence of any physical or orthopedic problem that could interfere with testing.
• History of acute or chronic instability, unsteadiness, or vertigo.
• Severe visual impairment.
• History of prior ear surgery.
• Presence of any neurological condition or disorder.
• History of migraines.
• Current use of medications that could affect balance or vestibular function (e.g., vestibular suppressants, sedatives).
• Use of alcohol or psychoactive substances within the last 48 hours prior to testing.

Sponsors & Collaborators

• Istinye University: lead

MeSH Terms

Conditions

Motion Sickness; Somatosensory Disorders; Dizziness

Condition Hierarchy (Ancestors)

Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Sensation Disorders; Neurologic Manifestations; Nervous System Diseases

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Dr. Assistant Professor

Study Record Dates

• First Submitted: May 26, 2026
• First Posted: June 2, 2026
• Study Start: June 1, 2026
• Primary Completion (Estimated): August 2, 2026
• Study Completion (Estimated): August 5, 2026
• Last Updated: June 26, 2026

Record last verified: 2026-06