UltraSound Guided Distal Radial Artery vS Conventional Transradial Access for Interventional Coronary Angiography

NCT07617259 | Recruiting

• 1 other identifier: 2/22.01.2026
• Study Type: interventional
• Target: 1,400
• Locations: 1 country
• Sites: 1

Brief Summary

Comparative study of ultrasound-guided distal radial access versus conventional radial access regarding the incidence of vascular access crossover.

Conditions

Radial Artery Access; Distal Radial Artery Access (dTRA)

Keywords

distal radial artery; dra; coronary; ultrasound; distal; dtra; u/s; ultrasound guided; ICA; coronary angiography

Outcome Measures

Primary Outcomes (1)

• crossover

  Need for a different access to begin the procedure other than the one specified in the patient's arm

  Periprocedural.Up to 5 mins will be allowed before giving up on designated method to obtain access

Secondary Outcomes (8)

• Arterial vasospasm

  periprocedural

• hemostasis

  Will be checked at set intervals of 30-60-90-180 mins post procedure

• Time until pci

  periprocedural

• radial artery occlusion

  30 days post procedure

• hematoma

  pre discharge , post procedure

Study Arms (2)

ultrasound guided distal radial artery

ACTIVE COMPARATOR

ultrasound guided distal radial artery acess for coronary angiography

Procedure: coronary angiography

ultrasound guided conventional transradial acess

ACTIVE COMPARATOR

ultrasound guided conventional transradial acess for coronary angiography

Procedure: coronary angiography

Interventions

coronary angiography PROCEDURE

Diagnostic and if indicated percutaneus coronary intervention during coronary angiography

Also known as: pci

ultrasound guided conventional transradial acess; ultrasound guided distal radial artery

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Indication for Invasive coronary angiography

You may not qualify if:

• STEMI
• Renal replacement therapy patients
• Serious dermal or bone deformity of the radiocarpal joint
• Shock

Sponsors & Collaborators

• University Hospital of Patras: lead

Study Sites (1)

University Hospital of Patras

Pátrai, Greece

RECRUITING

Related Publications (16)

• Mori S, Hirano K, Yamawaki M, Kobayashi N, Sakamoto Y, Tsutsumi M, Honda Y, Makino K, Shirai S, Ito Y. A Comparative Analysis between Ultrasound-Guided and Conventional Distal Transradial Access for Coronary Angiography and Intervention. J Interv Cardiol. 2020 Sep 8;2020:7342732. doi: 10.1155/2020/7342732. eCollection 2020.

  PMID: 32982609 BACKGROUND

• Moussa Pacha H, Alahdab F, Al-Khadra Y, Idris A, Rabbat F, Darmoch F, Soud M, Zaitoun A, Kaki A, Rao SV, Kwok CS, Mamas MA, Alraies MC. Ultrasound-guided versus palpation-guided radial artery catheterization in adult population: A systematic review and meta-analysis of randomized controlled trials. Am Heart J. 2018 Oct;204:1-8. doi: 10.1016/j.ahj.2018.06.007. Epub 2018 Jun 19.

  PMID: 30077047 BACKGROUND

• Ferrante G, Condello F, Rao SV, Maurina M, Jolly S, Stefanini GG, Reimers B, Condorelli G, Lefevre T, Pancholy SB, Bertrand O, Valgimigli M. Distal vs Conventional Radial Access for Coronary Angiography and/or Intervention: A Meta-Analysis of Randomized Trials. JACC Cardiovasc Interv. 2022 Nov 28;15(22):2297-2311. doi: 10.1016/j.jcin.2022.09.006.

  PMID: 36423974 BACKGROUND

• Hamandi M, Saad M, Hasan R, Megaly M, Abbott JD, Dib C, Szerlip M, Potluri S, Lotfi A, Kiemeneij F, Al-Azizi KM. Distal Versus Conventional Transradial Artery Access for Coronary Angiography and Intervention: A Meta-Analysis. Cardiovasc Revasc Med. 2020 Oct;21(10):1209-1213. doi: 10.1016/j.carrev.2020.03.020. Epub 2020 Mar 14.

  PMID: 32321695 BACKGROUND

• Feng C, Zong B, Liu Y, Chen M, Li S, Xu D, Han B. Comparison of distal transradial approach versus conventional transradial approach for coronary angiography and percutaneous coronary intervention: A prospective observational study. Heliyon. 2023 Jun 14;9(6):e17150. doi: 10.1016/j.heliyon.2023.e17150. eCollection 2023 Jun.

  PMID: 37360091 BACKGROUND

• Chen T, Li L, Li F, Lu W, Shi G, Li W, Yang A, Huang H, Xiao J, Zhang Q, Gu J, Xue S, Zhang L, Li L, Xu L, Ji R, Wang H, Cai G. Comparison of long-term radial artery occlusion via distal vs. conventional transradial access (CONDITION): a randomized controlled trial. BMC Med. 2024 Feb 8;22(1):62. doi: 10.1186/s12916-024-03281-7.

  PMID: 38331793 BACKGROUND

• Aminian A, Sgueglia GA, Wiemer M, Kefer J, Gasparini GL, Ruzsa Z, van Leeuwen MAH, Ungureanu C, Leibundgut G, Vandeloo B, Kedev S, Bernat I, Ratib K, Iglesias JF, Al Hage E, Posteraro GA, Pascut D, Maes F, Regazzoli D, Kakonyi K, Meijers TA, Colletti G, Krivoshei L, Lochy S, Zafirovska B, Horak D, Nolan J, Degrauwe S, Tobita K, Saito S. Distal Versus Conventional Radial Access for Coronary Angiography and Intervention: The DISCO RADIAL Trial. JACC Cardiovasc Interv. 2022 Jun 27;15(12):1191-1201. doi: 10.1016/j.jcin.2022.04.032. Epub 2022 May 17.

  PMID: 35595673 BACKGROUND

• Eid-Lidt G, Rivera Rodriguez A, Jimenez Castellanos J, Farjat Pasos JI, Estrada Lopez KE, Gaspar J. Distal Radial Artery Approach to Prevent Radial Artery Occlusion Trial. JACC Cardiovasc Interv. 2021 Feb 22;14(4):378-385. doi: 10.1016/j.jcin.2020.10.013.

  PMID: 33602433 BACKGROUND

• Koutouzis M, Kontopodis E, Tassopoulos A, Tsiafoutis I, Katsanou K, Rigatou A, Didagelos M, Andreou K, Lazaris E, Oikonomidis N, Maniotis C, Ziakas A. Distal Versus Traditional Radial Approach for Coronary Angiography. Cardiovasc Revasc Med. 2019 Aug;20(8):678-680. doi: 10.1016/j.carrev.2018.09.018. Epub 2018 Oct 2.

  PMID: 30314833 BACKGROUND

• Roh JH, Lee JH. Distal Radial Approach through the Anatomical Snuff Box for Coronary Angiography and Percutaneous Coronary Intervention. Korean Circ J. 2018 Dec;48(12):1131-1134. doi: 10.4070/kcj.2018.0293. No abstract available.

  PMID: 30403016 BACKGROUND

• Tsigkas G, Papageorgiou A, Moulias A, Kalogeropoulos AP, Papageorgopoulou C, Apostolos A, Papanikolaou A, Vasilagkos G, Davlouros P. Distal or Traditional Transradial Access Site for Coronary Procedures: A Single-Center, Randomized Study. JACC Cardiovasc Interv. 2022 Jan 10;15(1):22-32. doi: 10.1016/j.jcin.2021.09.037. Epub 2021 Dec 15.

  PMID: 34922888 BACKGROUND

• Rashid M, Kwok CS, Pancholy S, Chugh S, Kedev SA, Bernat I, Ratib K, Large A, Fraser D, Nolan J, Mamas MA. Radial Artery Occlusion After Transradial Interventions: A Systematic Review and Meta-Analysis. J Am Heart Assoc. 2016 Jan 25;5(1):e002686. doi: 10.1161/JAHA.115.002686.

  PMID: 26811162 BACKGROUND

• Valgimigli M, Landi A. Distal Transradial Access for Coronary Procedures: Old Certainties, Novel Challenges, and Future Horizons. JACC Cardiovasc Interv. 2022 Jan 10;15(1):33-38. doi: 10.1016/j.jcin.2021.10.032. Epub 2021 Dec 15. No abstract available.

  PMID: 34922887 BACKGROUND

• Shroff AR, Gulati R, Drachman DE, Feldman DN, Gilchrist IC, Kaul P, Lata K, Pancholy SB, Panetta CJ, Seto AH, Speiser B, Steinberg DH, Vidovich MI, Woody WW, Rao SV. SCAI expert consensus statement update on best practices for transradial angiography and intervention. Catheter Cardiovasc Interv. 2020 Feb;95(2):245-252. doi: 10.1002/ccd.28672. Epub 2019 Dec 27.

  PMID: 31880380 BACKGROUND

• Mason PJ, Shah B, Tamis-Holland JE, Bittl JA, Cohen MG, Safirstein J, Drachman DE, Valle JA, Rhodes D, Gilchrist IC; American Heart Association Interventional Cardiovascular Care Committee of the Council on Clinical Cardiology; Council on Cardiovascular and Stroke Nursing; Council on Peripheral Vascular Disease; and Council on Genomic and Precision Medicine. An Update on Radial Artery Access and Best Practices for Transradial Coronary Angiography and Intervention in Acute Coronary Syndrome: A Scientific Statement From the American Heart Association. Circ Cardiovasc Interv. 2018 Sep;11(9):e000035. doi: 10.1161/HCV.0000000000000035.

  PMID: 30354598 BACKGROUND

• Neumann FJ, Sousa-Uva M, Ahlsson A, Alfonso F, Banning AP, Benedetto U, Byrne RA, Collet JP, Falk V, Head SJ, Juni P, Kastrati A, Koller A, Kristensen SD, Niebauer J, Richter DJ, Seferovic PM, Sibbing D, Stefanini GG, Windecker S, Yadav R, Zembala MO; ESC Scientific Document Group. 2018 ESC/EACTS Guidelines on myocardial revascularization. Eur Heart J. 2019 Jan 7;40(2):87-165. doi: 10.1093/eurheartj/ehy394. No abstract available.

  PMID: 30165437 BACKGROUND

MeSH Terms

Conditions

Congenital chloride diarrhea

Interventions

alpha 1-Antitrypsin

Intervention Hierarchy (Ancestors)

Glycoproteins; Glycoconjugates; Carbohydrates; Serpins; Peptides; Amino Acids, Peptides, and Proteins; Acute-Phase Proteins; Blood Proteins; Proteins; Alpha-Globulins; Serum Globulins; Globulins

Central Study Contacts

Athinagoras Theofilatos

CONTACT

+30 6946747300; athinag@gmail.com

Grigorios Tsigas, assistant professor

CONTACT

+30 6974466662

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: CARE PROVIDER, OUTCOMES ASSESSOR
• Purpose: OTHER
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Tsigas Grigorios pHD,Assistant proffessor of cardiology at University Hospital of Patras

Study Record Dates

• First Submitted: May 12, 2026
• First Posted: June 1, 2026
• Study Start: May 12, 2026
• Primary Completion (Estimated): May 12, 2028
• Study Completion (Estimated): November 1, 2028
• Last Updated: June 1, 2026

Record last verified: 2026-05

Locations

GR (1)