QLF and Digital Imaging for Caries Activity Assessment After Orthodontic Treatment

NCT07608471 | Not Yet Recruiting DMC

• 1 other identifier: UEB CIE2025-108
• Study Type: observational
• Target: 30
• Locations: 0 countries
• Sites: N/A

Brief Summary

This prospective longitudinal observational study aims to evaluate the diagnostic performance and agreement of Smartphone photography, intraoral 3D imaging, Quantitative Light-Induced Fluorescence Digital (QLF-D), and ICDAS clinical criteria for assessing non-cavitated caries lesion activity in post-orthodontic patients under a preventive follow-up program. Thirty participants aged 11 to 46 years with active initial caries lesions will be followed for three months. Clinical examinations, QLF-D imaging, smartphone photographs, and intraoral 3D scans will be obtained at baseline and follow-up visits combined with professional prophylaxis and oral hygiene reinforcement. The study will analyze changes in lesion activity, fluorescence parameters, and surface characteristics over time, as well as the agreement and diagnostic performance among the evaluated methods.

Conditions

Dental Caries; White Spot Lesions; Caries Lesion Activity; Post-Orthodontic Enamel Demineralization

Keywords

Dental Caries; Dental Caries White Spot Lesions; Caries Lesion Activity; Post-Orthodontic Enamel Demineralization

Outcome Measures

Primary Outcomes (1)

• Diagnostic Agreement Measured by Weighted Kappa Between ICDAS Clinical Assessment and QLF-D, Smartphone Photography, and Intraoral 3D Imaging for Non-Cavitated Caries Lesion Activity

  Diagnostic agreement among ICDAS clinical criteria, QLF-D fluorescence parameters, smartphone intraoral photographs, and intraoral 3D imaging for identifying active and inactive non-cavitated caries lesions in post-orthodontic patients.

  Baseline, 3 months and 6 months

Study Arms (1)

Post-Orthodontic Patients With Non-Cavitated Caries Lesions

Participants aged 11 to 46 years who have completed fixed orthodontic treatment and present at least four active non-cavitated caries lesions (ICDAS 1-3) on vestibular surfaces of anterior teeth or premolars. Participants will undergo clinical assessment using ICDAS criteria, QLF-D imaging, smartphone photography, and intraoral 3D scanning during a three-month preventive follow-up program that includes professional prophylaxis and oral hygiene reinforcement.

Eligibility Criteria

• Age: 11 Years - 46 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

The study population will include post-orthodontic patients from Bogotá, Colombia, aged 11 to 46 years, presenting active non-cavitated caries lesions on vestibular tooth surfaces. Participants will be recruited from university clinical settings and enrolled in a preventive follow-up program involving clinical and digital caries assessment methods.

You may qualify if:

• Participants aged 11 to 46 years
• Completed fixed orthodontic treatment
• Presence of at least four active non-cavitated caries lesions (ICDAS 1-3)
• Lesions located on vestibular surfaces of anterior teeth and/or premolars
• Ability to attend follow-up visits during the three-month study period
• Signed informed consent and/or assent form

You may not qualify if:

• Systemic conditions affecting salivary flow or enamel structure
• Extensive cavitated lesions requiring restorative treatment
• Ongoing orthodontic treatment
• Use of medications that significantly affect oral conditions
• Inability to cooperate with imaging procedures or follow-up visits

Sponsors & Collaborators

• Universidad El Bosque, Bogotá: lead

MeSH Terms

Conditions

Dental Caries

Condition Hierarchy (Ancestors)

Tooth Demineralization; Tooth Diseases; Stomatognathic Diseases

Central Study Contacts

Andrea Cortes, PhD

CONTACT

312 3654862; cortesandrea@unbosque.edu.co

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: PhD

Study Record Dates

• First Submitted: May 14, 2026
• First Posted: May 27, 2026
• Study Start: July 21, 2026
• Primary Completion (Estimated): December 4, 2026
• Study Completion (Estimated): April 22, 2027
• Last Updated: May 27, 2026

Record last verified: 2026-05

Data Sharing

• IPD Sharing: Will not share