Effects of Platelet-Rich Fibrin After Mandibular Third Molar Surgery in Smokers and Nonsmokers

NCT07604584 | Completed

• 1 other identifier: 36290600/51
• Study Type: interventional
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

Mandibular third molar surgery is commonly associated with postoperative pain, swelling, and trismus. Platelet-rich fibrin (PRF) has been proposed as a biological adjunct to improve postoperative healing; however, its effectiveness in smokers remains unclear. This prospective randomized split-mouth clinical study aimed to evaluate the effects of PRF on postoperative pain, swelling, trismus, and analgesic consumption after impacted mandibular third molar surgery in smokers and nonsmokers. Thirty patients with bilaterally impacted mandibular third molars were included. PRF was placed in one extraction socket, while the contralateral socket served as the control site. Postoperative clinical outcomes were assessed during the first postoperative week and compared between smoking and nonsmoking patients.

Conditions

Impacted Mandibular Third Molar; Postoperative Pain; Trismus; Facial Swelling

Keywords

Platelet-Rich Fibrin; Mandibular Third Molar; Postoperative Pain; Smoking; Swelling; Trismus

Outcome Measures

Primary Outcomes (1)

• Postoperative Pain Intensity

  Postoperative pain intensity assessed using a 100-mm visual analog scale (VAS) after impacted mandibular third molar surgery.

  Postoperative days 1, 2, 3, and 7

Secondary Outcomes (3)

• Postoperative Facial Swelling

  Preoperative period and postoperative days 1, 2, 3, and 7

• Postoperative Trismus

  Preoperative period and postoperative days 1, 2, 3, and 7

• Postoperative Analgesic Consumption

  Postoperative days 1, 2, 3, and 7

Study Arms (2)

PRF-treated socket

EXPERIMENTAL

Platelet-rich fibrin (PRF) was placed into the extraction socket following impacted mandibular third molar surgery.

Biological: Platelet-Rich Fibrin

Control socket

NO INTERVENTION

The contralateral extraction socket was primarily closed without PRF application after mandibular third molar surgery.

Interventions

Platelet-Rich Fibrin BIOLOGICAL

Autologous platelet-rich fibrin prepared from venous blood by centrifugation and placed into the extraction socket after mandibular third molar extraction.

PRF-treated socket

Eligibility Criteria

• Age: 18 Years - 35 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Systemically healthy patients aged between 18 and 35 years
• Bilaterally impacted mandibular third molars
• Mandibular third molars classified as Pell and Gregory Class I, Position C
• Mandibular third molars classified as Parant Class II difficulty
• Smoking and nonsmoking patients
• Patients willing to participate and provide written informed consent

You may not qualify if:

• Presence of acute infection or pericoronitis
• Pregnancy or lactation
• Alcohol or substance abuse
• Use of oral contraceptives
• Menstrual period during surgery
• Antibiotic use within the previous month
• Smoking more than 10 cigarettes per day
• Agitation or inability to cooperate
• Incomplete follow-up data
• Systemic disease contraindicating oral surgery

Sponsors & Collaborators

• Ankara University: lead

Study Sites (1)

Ankara University Faculty of Dentistry

Ankara, 06560, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Pain, Postoperative; Trismus; Smoking

Condition Hierarchy (Ancestors)

Postoperative Complications; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Pain; Neurologic Manifestations; Signs and Symptoms; Spasm; Neuromuscular Manifestations; Nervous System Diseases; Behavior

Study Officials

• Mehmet Emre Yurttutan, PhD, DDS

  Ankara University, Faculty of Dentistry, Department of Oral and Maxillofacial Surgery

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Research Assistant

Model Details: This study was designed as a prospective randomized split-mouth clinical trial in which PRF was applied to one extraction socket, while the contralateral extraction socket served as the control site without PRF application. Bilateral mandibular third molar extractions were performed at least two weeks apart in the same patients. Smoking status was evaluated as a subgroup factor.

Study Record Dates

• First Submitted: May 17, 2026
• First Posted: May 22, 2026
• Study Start: May 15, 2017
• Primary Completion: December 21, 2018
• Study Completion: December 21, 2018
• Last Updated: May 22, 2026

Record last verified: 2026-05

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)