MRI and Local Anesthesia

NCT07602686 | Not Yet Recruiting FDA Device

• 1 other identifier: STUDY00025764
• Study Type: interventional
• Target: 102
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this research is to investigate the utility of using dental-dedicated MRI as a measurement tool to observe and evaluate the administration of local anesthesia in dental patients.

Conditions

Dental Anesthesia

Outcome Measures

Primary Outcomes (6)

• Patient reported sensation - 5min

  Minimum value: No numbness Maximum value: Numb High scores mean a successful outcome for the block.

  5 minutes after the nerve block

• Patient reported sensation - 1 hour

  Minimum value: No numbness Maximum value: Numb High scores mean a successful outcome for the block.

  within 1 hour of the nerve block

• Ability to sense light touch

  binary scale. Options are yes or no

  within 1 hour of the nerve block

• Ability to sense pressure

  Minimum value: 1.65 Maximum value: 6.65 Low scores mean that the participant can sense more, and that the block was less effective

  within 1 hour of the nerve block

• Ability to sense direction of touch (only if can sense VonFrey fibers)

  Patient reports direction of sensation (up/down/right/left). This is scored 5 times per site

  within 1 hour of the nerve block

• Ability to distinguish sharp versus dull (only if can sense VonFrey fibers)

  Patient reports sharp versus dull sensation. This is scored 5 times per site

  within 1 hour of the nerve block

Study Arms (1)

ddMRI scanning

EXPERIMENTAL

The ddMRI will take place after anesthesia administration. The ddMRI will allow researchers to see and measure the distribution of the local anesthetic, as well as the the area of the local anesthetic and the intensity on MRI.

Device: ddMRI

Interventions

ddMRI DEVICE

Dental MRI imaging

ddMRI scanning

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Adult age 18 or older
• Health status of American Society of Anesthesiologists (ASA) class 1 or 2
• Able to provide informed consent
• Able to appear in person at OMRIC on the days indicated for the study

You may not qualify if:

• ASA class 3 or higher
• Pregnant patients
• Taking any medication that would affect pain perception or interact with local anesthetic
• Allergic/history of adverse reaction to local anesthetic or any component in the local anesthetic
• Paresthesia in the area of innervation of Cranial Nerve V3
• Active infection or abscess in the oral and maxillofacial region
• History of temporomandibular disorder, maximum incisal opening less than 15mm
• History of recent dental trauma (within the past 6 months)
• Dental hypersensitivity
• Claustrophobia and/or conditions of anxiety or motion disorder (for MRI purposes)
• Metallic, electronic, or magnetic implants or devices classified as MR Unsafe or Conditional by the American College of Radiology
• Unable to give informed consent

Sponsors & Collaborators

• University of Minnesota: lead

Study Sites (1)

University of Minnesota

Minneapolis, Minnesota, 55455, United States

Location

Study Officials

• Rachel Uppgaard, DDS, FACS

  University of Minnesota

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Rachel Uppgaard, DDS, FACS

CONTACT

612-209-9176; uppg0003@umn.edu

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: SUPPORTIVE CARE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 30, 2026
• First Posted: May 22, 2026
• Study Start (Estimated): June 1, 2026
• Primary Completion (Estimated): July 1, 2029
• Study Completion (Estimated): July 1, 2029
• Last Updated: May 22, 2026

Record last verified: 2026-05

Locations

US (1)