Effect of Cold Atmospheric Plasma on Patient Comfort During Dental Anesthesia

NCT07288125 | Completed

• 1 other identifier: Harran university HRÜ/25.13.39
• Study Type: interventional
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to investigate the effectiveness of cold atmospheric plasma, a laser-like biophysical method, in reducing injection pain experienced during local infiltration anesthesia in dental treatments. The purpose is to determine whether applying cold atmospheric plasma before the injection can decrease the level of pain at the injection site and improve patient comfort. In this study, to help reduce the pain felt during the dental injection, some patients will receive a cold plasma application before the needle is administered. The device is held close to the gum area where the injection will be given-without touching the tissue-for about one minute to help the area relax. Afterwards, the standard local anesthetic injection is performed. On the opposite side of the mouth, only the normal injection will be given. Pain levels on both sides and patient satisfaction will be recorded through questions asked after the procedure. If you choose to participate in this research, your dental treatments will still be completed, and the pain felt during the injection may be reduced. Additionally, by participating, you will contribute to scientific knowledge and to the development of a potential future treatment option.

Conditions

Cold Atmospheric Plasma; Dental Anesthesia

Keywords

Cold Atmospheric Plasma; Local Anesthesia; Injection Pain; Dental Anxiety

Outcome Measures

Primary Outcomes (1)

• Pain Intensity During Local Anesthesia Injection

  The primary outcome was the intensity of pain experienced during the injection, assessed by the patient using a visual analog scale (VAS). The VAS ranged from 0 to 10, where 0 represented "no pain" and 10 represented "unbearable pain." Immediately after

  Immediately after injection

Secondary Outcomes (1)

• Patient satisfaction related to the injection experience

  Immediately after injection

Study Arms (2)

CAP

EXPERIMENTAL

Cold Atmospheric Plasma applied before injection

Other: Cold Atmospheric Plasma

Control

ACTIVE COMPARATOR

No pretreatment, standard injection only

Other: No pretreatment

Interventions

No pretreatment OTHER

No pretreatment is applied. The control side receives only the standard buccal local infiltration anesthesia.

Control

Cold Atmospheric Plasma OTHER

Cold atmospheric plasma is applied to the oral mucosa at the planned injection site for 30 seconds using a non-contact atmospheric plasma device before local infiltration anesthesia.

CAP

Eligibility Criteria

• Age: 18 Years - 40 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Being between 18 and 40 years of age;
• American Society of Anesthesiologists (ASA) physical status classification I (systemically healthy);
• No known allergy or intolerance to local anesthetic agents or cold atmospheric plasma (CAP);
• Presence of similar bilateral dental treatment indications in the maxilla or mandible.

You may not qualify if:

• Pregnancy or breastfeeding;
• Presence of active lesions, ulceration, or signs of infection in the mucosa at the injection site;
• Immunodeficiency or systemic immunosuppressive therapy;
• Use of anticoagulant medications;
• Previous exposure to CAP therapy for any purpose;
• History of allergy to local anesthetic agents;
• Presence of neurological or psychiatric disorders that may affect pain perception.

Sponsors & Collaborators

• Kahramanmaras Sutcu Imam University: lead

Study Sites (1)

Kahramanmaras Sutcu Imam University, Faculty of Dentistry

Kahramanmaraş, Turkey (Türkiye)

Location

Related Publications (2)

• Jagtap B, Bhate K, Magoo S, S N S, Gajendragadkar KS, Joshi S. Painless injections-a possibility with low level laser therapy. J Dent Anesth Pain Med. 2019 Jun;19(3):159-165. doi: 10.17245/jdapm.2019.19.3.159. Epub 2019 Jun 30.

  PMID: 31338422 RESULT

• Ucar G, Sermet Elbay U, Elbay M. Effects of low level laser therapy on injection pain and anesthesia efficacy during local anesthesia in children: A randomized clinical trial. Int J Paediatr Dent. 2022 Jul;32(4):576-584. doi: 10.1111/ipd.12936. Epub 2022 Feb 8.

  PMID: 34738278 RESULT

MeSH Terms

Interventions

Plasma Gases

Intervention Hierarchy (Ancestors)

Gases; Inorganic Chemicals

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: OTHER
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Study Record Dates

• First Submitted: December 4, 2025
• First Posted: December 17, 2025
• Study Start: September 1, 2025
• Primary Completion: October 27, 2025
• Study Completion: November 3, 2025
• Last Updated: December 23, 2025

Record last verified: 2025-12

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)