Sensory Feedback and Hand Motor Adaptation

NCT07598695 | Recruiting Early Phase 1

• 2 other identifiers: STUDY000067851R15HD114052
• Study Type: interventional
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

The following experiment will be conducted with 15 chronic stroke survivors and 15 control subjects. Subjects will perform hand movements in the virtual reality environment using a head-mounted display. Quest's onboard cameras allow real-time tracking of hand motion, estimating joint angles of the finger and the thumb. For each feedback manipulation condition (i.e., movement amplification or reduction), the estimated joint angles will be multiplied by a factor greater than 1 (amplification) or a factor smaller than 1 (reduction). Then the newly-estimated hand posture will be displayed in the VR environment. Subjects will be randomly assigned into two groups (A and B), who will receive the assistance in a different order. Subjects will perform finger extension under three conditions: no sensory modulation, movement visual feedback (VF) amplification, and movement VF reduction (error augmentation), while their movement muscle activation patterns are recorded.

Conditions

Stroke

Keywords

Stroke; Muscle coordination; Visual feedback; Hand

Outcome Measures

Primary Outcomes (1)

• Joint range of motion (ROM)

  range of motion of individual finger joints under each condition, measured by embedded cameras that digitize individual finger segments

  Periprocedural

Secondary Outcomes (1)

• Muscle activation

  Periprocedural

Study Arms (2)

Visual ROM augmentation followed by visual ROM reduction

EXPERIMENTAL

Device: Visual ROM augmentation; Device: Visual ROM reduction

Visual ROM reduction followed by visual ROM augmentation

EXPERIMENTAL

Device: Visual ROM augmentation; Device: Visual ROM reduction

Interventions

Visual ROM augmentation DEVICE

Finger joint ROM is amplified.

Visual ROM augmentation followed by visual ROM reduction; Visual ROM reduction followed by visual ROM augmentation

Visual ROM reduction DEVICE

Visual feedback of finger joint ROM is reduced.

Visual ROM augmentation followed by visual ROM reduction; Visual ROM reduction followed by visual ROM augmentation

Eligibility Criteria

• Age: 20 Years - 70 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Age: 18 - 70 years old
• First-ever unilateral cortical stroke with resultant hemiparesis at least 6 months prior to the experimental testing
• Fugl-Meyer Upper Extremity Section 31 - 55

You may not qualify if:

• Presence of concurrent severe medical illness
• Pain in hand or arm with movements
• Loss of voluntary control of fingers and thumb
• Inability to provide informed consent
• Musculoskeletal injuries (e.g., fracture) or medical complications (e.g., severe cardiovascular disease).
• Healthy Group:

Sponsors & Collaborators

• The Catholic University of America: lead
• Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD): collaborator

Study Sites (1)

Catholic University of America

Washington D.C., District of Columbia, 20064, United States

RECRUITING

MeSH Terms

Conditions

Stroke

Condition Hierarchy (Ancestors)

Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases

Central Study Contacts

Sang Wook Lee, PhD

CONTACT

202-319-6218; leesw@cua.edu

Study Design

• Study Type: interventional
• Phase: early phase 1
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 5, 2026
• First Posted: May 20, 2026
• Study Start: October 1, 2025
• Primary Completion (Estimated): October 1, 2026
• Study Completion (Estimated): December 31, 2026
• Last Updated: May 20, 2026

Record last verified: 2026-05

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)