Clinical Study on the Effects of Pulmonary Vessels on Cryoablation and Preventive Embolization Strategies

NCT07594834 | Not Yet Recruiting

• 1 other identifier: 2026GSlungcryo
• Study Type: interventional
• Target: 20
• Locations: 0 countries
• Sites: N/A

Brief Summary

This study targeted high-risk individuals with incomplete ablation and performed selective pulmonary artery embolization before lung cryoablation, which could enhance the therapeutic effect and reduce the risk of intraoperative bleeding. Previous studies have shown that selective pulmonary artery embolization before ablation has no adverse reactions related to embolization. In this study, gelatin sponge particles were used for selective pulmonary artery embolization. Gelatin sponge is an absorbable embolic material that can be absorbed and degraded in the human body within about 7 days, which has high safety and a low probability of adverse reactions. The surgical risks are detailed in the surgical protocol. The study aims to optimize the lung cryoablation strategy for high-risk individuals with incomplete ablation, aiming to improve the prognosis of high-risk recurrent patients. The two groups of patients underwent lung CT reexamination every three months after surgery to observe the tumor ablation situation.

Conditions

Lung Cancer

Outcome Measures

Primary Outcomes (1)

• ablation zone

  The CT images obtained during the operation are subjected to three-dimensional reconstruction, and the ROI is delineated. The long diameter, short diameter and volume of the ablation area are measured.Compare the values of various aspects of the smiling areas between the experimental group and the control group.

  Immediately assess the extent of the ablation after the ablation needle is withdrawn.

Study Arms (2)

experimental group

EXPERIMENTAL

Procedure: Pulmonary artery embolization

control group

NO INTERVENTION

Interventions

Pulmonary artery embolization PROCEDURE

In this study, using DSA guidance, gelatin sponge particles were used to artificially embolize the thicker pulmonary arteries around the tumor, thereby reducing the heat sink effect and complications, and improving the efficacy of lung cryoablation.

experimental group

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Individuals at high risk of incomplete ablation (for example, there are vessels with a diameter greater than 3mm within 1cm around the pulmonary nodule);
• Scheduled for lung cryoablation, meeting the surgical indications and without any specific contraindications;
• The long diameter of the lung tumor is less than 3cm;
• The single cryoablation needle will be used. -

You may not qualify if:

• Postoperative complications such as massive pneumothorax and bleeding occurred, which affected the observation of the ice ball's shape;
• Poor image quality or incomplete images. -

Sponsors & Collaborators

• Haibo Shao: lead

MeSH Terms

Conditions

Lung Neoplasms

Condition Hierarchy (Ancestors)

Respiratory Tract Neoplasms; Thoracic Neoplasms; Neoplasms by Site; Neoplasms; Lung Diseases; Respiratory Tract Diseases

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: offices director

Study Record Dates

• First Submitted: April 12, 2026
• First Posted: May 19, 2026
• Study Start (Estimated): June 30, 2026
• Primary Completion (Estimated): June 30, 2027
• Study Completion (Estimated): June 30, 2030
• Last Updated: May 19, 2026

Record last verified: 2026-04