Implementing Low-dose ct Lung Cancer Screening in France.
IMPULSION
2 other identifiers
interventional
20,000
1 country
2
Brief Summary
The main objective is to estimate the detection rate of lung cancer in the population screened by low-dose chest CT scans.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for not_applicable lung-cancer
Started Jun 2026
Longer than P75 for not_applicable lung-cancer
2 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
February 3, 2026
CompletedFirst Posted
Study publicly available on registry
April 7, 2026
CompletedStudy Start
First participant enrolled
June 1, 2026
ExpectedPrimary Completion
Last participant's last visit for primary outcome
June 1, 2031
Study Completion
Last participant's last visit for all outcomes
December 1, 2031
May 20, 2026
April 1, 2026
5 years
February 3, 2026
May 18, 2026
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Lung cancer detection rate in the population screened using low-dose chest CT
Number of individuals with detected cancer divided by the number of individuals included in the study, i.e., an intention-to-screen analysis.
42 months
Secondary Outcomes (23)
Evaluation of screening performance
42 months
Exploration and comparison of several methods for identifying and inviting the target population
18 months
Measurement of participation rate
18 months
Measurement of response rates to follow-up invitations
42 months
Measurement of adherence to screening rounds
18 months , 30 months & 54 months
- +18 more secondary outcomes
Interventions
Baseline low-dose CT acquisition, then at 1 year and 3 years to depict suspicious lung nodules
Eligibility Criteria
You may qualify if:
- Adults aged 50-74 years
- Active or former smoker having quit less than 15 years ago
- Smoking history of at least 20 pack-years, or 15 cigarettes/day for 25 years or 10 cigarettes/day for 30 years
- Affiliation with a social security scheme
- Written informed consent prior to study participation
You may not qualify if:
- Chest CT scan performed within the previous 12 months
- Signs of respiratory infection (fever, productive cough)
- Severe co-morbidities contraindicating exploration and/or management (including stereotactic surgery or radiotherapy) of lung cancers
- Poor general status (PS2 and above)
- Rest dyspnea (mMRC4)
- Cancer under active surveillance by thoracic computed tomography (CT pr PET-CT)
- Personal history of lung cancer
- Symptoms raising suspicion of lung cancer (hemoptysis, unexplained weight loss, recent onset or modification of respiratory symptoms,…)
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (2)
HCL - Hôpital Lyon Sud
Lyon, France, 69495, France
Hôpital Cochin
Paris, Île-de-France Region, 75014, France
Related Links
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Marie-Pierre REVEL, PhD
Assistance Publique - Hôpitaux de Paris
- STUDY CHAIR
Sébastien COURAUD, PhD
Hospices Civils de Lyon
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- NON RANDOMIZED
- Masking
- NONE
- Purpose
- SCREENING
- Intervention Model
- SINGLE GROUP
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
February 3, 2026
First Posted
April 7, 2026
Study Start (Estimated)
June 1, 2026
Primary Completion (Estimated)
June 1, 2031
Study Completion (Estimated)
December 1, 2031
Last Updated
May 20, 2026
Record last verified: 2026-04
Data Sharing
- IPD Sharing
- Will not share