Comparing the Effects of Macquarie Injury Management Group Protocol and Targeted Knee Exercise Program on Pain, Range of Motion and Functional Disability in Patients With Grade II Knee Osteoarthritis

NCT07593599 | Completed DMC

• 1 other identifier: GIU/REC/26-32
• Study Type: interventional
• Target: 84
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this clinical trial is to learn if the macquire injury management group protocol and targeted knee exercise program works to treat knee osteoarthritis grade 2.This clinical trial compares the effects of macquire injury management group protocol and targeted knee exercise program on pain and range of motion and functional disability in patients with knee osteoarthritis grade 2.Adults with knee osteoarthritis grade 2 were included in this study. A total of 84 participants were divided into two groups with 42 patients in each group. One group received macquire injury management group protocol and the other group received targeted knee exercise program. Pain was assessed using the numeric pain rating scale and functional disability was measured using WOMAC index. Range of motion was also evaluated before and after treatment by universal goniometer.

Conditions

Knee Osteoarthritis (Knee OA)

Keywords

Osteoarthritis; Knee joint; Pain

Outcome Measures

Primary Outcomes (1)

• Pain by numeric pain rating scale

  The level of pain was assessed using the Numeric Pain Rating Scale (NPRS), which is a simple and widely used tool for evaluating pain intensity. In this scale, individuals are asked to rate their pain on a scale from 0 to 10, where 0 indicates no pain and 10 represents the worst possible pain. Based on the categorization by Fiddiyanti et al. (2024), pain scores ranging from 1-3 are considered mild pain, 4-6 indicate moderate pain, and 7-10 represent severe pain. This scale provides a quick and reliable measure of a person's subjective pain experience.

  Baseline , 6th week and 12th week post intervention

Secondary Outcomes (2)

• Range of motion by universal goniometer

  Baseline, 6th week and 12th week post intervention.

• Functional disability by WOMAC index

  Baseline, 6th week and 12th week post intervention.

Study Arms (2)

macquire injury management group Protocol (MIMG )

EXPERIMENTAL

The macquire injury management group Protocol is known for its emphasis on soft tissue mobilization. The patients were made to lie down in a supine position and their knee joints were in an extended position during the treatment. In order to perform the soft tissue mobilization, the physiotherapist gently worked on the soft tissues of the knee joint for about two to three minutes using both his hands. In addition to the manual treatment method, the patients also underwent 45 minutes of physical therapy exercises

Procedure: Macquire injury management group protocol

Targeted knee exercise program

ACTIVE COMPARATOR

targeted knee exercise program , was aimed at improving the strength, proprioception, and stability of the knee joint. It comprised of progressively increasing knee exercises for the quadriceps (for example, straight leg raises and terminal knee extensions), hip abductors, and hamstrings. In addition to these exercises, there were also exercises to increase the stability of the joint by means of proprioceptive exercises involving single leg standing and dynamic stability exercises. Functional exercises including sit-to-stand and step up were also included. The intervention period lasted for 12 weeks with 3 sessions per week.

Procedure: Targeted knee exercise program

Interventions

Macquire injury management group protocol PROCEDURE

The patients were made to lie down in a supine position and their knee joints were in an extended position during the treatment. In order to perform the soft tissue mobilization, the physiotherapist gently worked on the soft tissues of the knee joint for about two to three minutes using both his hands. In addition to the manual treatment method, the patients also underwent 45 minutes of physical therapy exercises

macquire injury management group Protocol (MIMG )

Targeted knee exercise program PROCEDURE

It comprised of progressively increasing knee exercises for the quadriceps (for example, straight leg raises and terminal knee extensions), hip abductors, and hamstrings. In addition to these exercises, there were also exercises to increase the stability of the joint by means of proprioceptive exercises involving single leg standing and dynamic stability exercises. Functional exercises including sit-to-stand and step up were also included. The intervention period lasted for 12 weeks with 3 sessions per week.

Targeted knee exercise program

Eligibility Criteria

• Age: 40 Years - 60 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Both female and male subjects aged between 40 to 60 year
• Diagnosed knee osteoarthritis, Grade II by Kellegren Lawrence.

You may not qualify if:

• Any surgical procedure done for lower extremity
• Any infection
• Post traumatic knee stiffness
• Secondary knee osteoarthritis
• Peripheral vascular disease.

Sponsors & Collaborators

• Green International University: lead

Study Sites (1)

Johar pain relief center ,Lahore

Lahore, Punjab Province, 54000, Pakistan

Location

MeSH Terms

Conditions

Osteoarthritis, Knee; Osteoarthritis; Pain

Condition Hierarchy (Ancestors)

Arthritis; Joint Diseases; Musculoskeletal Diseases; Rheumatic Diseases; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Comparative Effects of Macquarie Injury Management Group Protocol and Targeted Knee Exercise Program on Pain, Range of Motion and Functional Disability in Patients with Grade II Knee Osteoarthritis

Model Details: This is a randomized, parallel-group interventional study. Participants with Grade II Knee Osteoarthritis were randomly assigned in a 1:1 ratio to one of two treatment arms. Group A received macquire injury management group protocol and Group B received targeted knee exercise program. Both interventions were administered for the specifiec treatment period to compare their effectiveness on pain reduction and improvement in knee range of motion and functional disability.

Study Record Dates

• First Submitted: May 12, 2026
• First Posted: May 18, 2026
• Study Start: April 28, 2025
• Primary Completion: April 29, 2026
• Study Completion: May 4, 2026
• Last Updated: May 18, 2026

Record last verified: 2026-05

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, SAP, ICF, CSR
• Time Frame: It will be available after completion of study.
• Access Criteria: Data requests should be sent to the corresponding author. Access will be granted to qualified researchers for approved research proposals. Data will be de-identified before sharing.

Locations

PA (1)