NCT06930677

Brief Summary

Study in patients with knee osteoarthritis treated by embolization using NBGM200

Trial Health

80
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
72

participants targeted

Target at P50-P75 for not_applicable

Timeline
9mo left

Started Apr 2025

Typical duration for not_applicable

Geographic Reach
2 countries

3 active sites

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress59%
Apr 2025Feb 2027

First Submitted

Initial submission to the registry

April 9, 2025

Completed
7 days until next milestone

First Posted

Study publicly available on registry

April 16, 2025

Completed
1 day until next milestone

Study Start

First participant enrolled

April 17, 2025

Completed
1.8 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

February 1, 2027

Expected
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

February 1, 2027

Last Updated

November 19, 2025

Status Verified

May 1, 2025

Enrollment Period

1.8 years

First QC Date

April 9, 2025

Last Update Submit

November 17, 2025

Conditions

Knee Osteoarthritis (Knee OA)

Outcome Measures

Primary Outcomes (1)

  • Knee Injury and Osteoarthritis Outcome score (KOOS-12)

    Knee Injury and Osteoarthritis Outcome score (KOOS-12) is to evaluate the pain, function and quality of life. The total score ranges from 0 to 100, where higher scores indicate better outcomes.

    6 months post treatment

Secondary Outcomes (2)

  • Visual Analog Scale(VAS)

    6 months post treatment

  • Whole Organ Magnetic Resonance Imaging Score (WORMS)

    6 months post treatment

Study Arms (1)

MSK embolization

EXPERIMENTAL
Device: embolization therapy

Interventions

embolization therapyDEVICE

MSK embolization

MSK embolization

Eligibility Criteria

Age50 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Osteoarthritis proven by MR-imaging

You may not qualify if:

  • Current local infection
  • Life expectancy less than 6 months

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (3)

University Hospital Ghent

Ghent, Belgium

RECRUITING

Uz Leuven

Leuven, Belgium

RECRUITING

Elisabeth-Tweesteden Hospital

Tilburg, Netherlands

RECRUITING

MeSH Terms

Conditions

Osteoarthritis, Knee

Interventions

Embolization, Therapeutic

Condition Hierarchy (Ancestors)

OsteoarthritisArthritisJoint DiseasesMusculoskeletal DiseasesRheumatic Diseases

Intervention Hierarchy (Ancestors)

Hemostatic TechniquesTherapeuticsTherapeutic Occlusion

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NA
Masking
NONE
Purpose
TREATMENT
Intervention Model
SINGLE GROUP
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

April 9, 2025

First Posted

April 16, 2025

Study Start

April 17, 2025

Primary Completion (Estimated)

February 1, 2027

Study Completion (Estimated)

February 1, 2027

Last Updated

November 19, 2025

Record last verified: 2025-05

Locations

NL(1)BE(2)