EFFECTS OF TWO ANESTHESİA TECHNİQUES ON INFLAMMATORY RESPONSE AND AMİNO ACİD METABOLİSM İN THYROİD SURGERY

NCT07592832 | Not Yet Recruiting

• 1 other identifier: Perioperative Inflammatory Res
• Study Type: interventional
• Target: 60
• Locations: 0 countries
• Sites: N/A

Brief Summary

The main aim of this study is to compare the effects of two different anesthesia methods-(1) general anesthesia alone and (2) combination of general anesthesia with cervical plexus block-on postoperative inflammatory process and amino acid metabolism in patients undergoing thyroidectomy.

Conditions

General Anesthesia; Cervical Plexus Block; Thyroid Surgery

Outcome Measures

Primary Outcomes (2)

• Perioperative Inflammatory Response

  IL-1β, TNF-α, IL-6, IL-10, and IL-40 levels will be measured 1 hour before surgery, and then 2 and 6 hours after surgery, and these values will then be compared.

  Before the procedure, and at 2 and 6 hours after the procedure.

• Inflammatory Response

  IL-1β, TNF-α, IL-6, IL-10, and IL-40 levels will be measured 1 hour before surgery, and then 2 and 6 hours after surgery, and these values will then be compared.

  Before the procedure, and at 2 and 6 hours after the procedure.

Study Arms (2)

GENERAL ANESTHESIA

ACTIVE COMPARATOR

THIS GROUP WILL INCLUDE PATIENTS WHO ARE UNDER GENERAL ANESTHESIA.

Procedure: cervical plexus block

cervical plexus block

ACTIVE COMPARATOR

IN THIS GROUP, CERVICAL PLEXUS BLOCK WILL BE PERFORMED IN ADDITION TO GENERAL ANESTHESIA.

Procedure: General Anesthesia

Interventions

General Anesthesia PROCEDURE

In our study, one patient group will receive only general anesthesia, while the other group will receive general anesthesia in addition to ultrasound-guided cervical plexus block. The inflammatory response is a natural response of the body's immune system to surgical trauma, and it can vary depending on the anesthetic agent used. In regulating this response, molecules such as IL-1β, TNF-α, IL-6, IL-10, and IL-40 are important indicators that determine the severity and duration of inflammation. These parameters will be examined and compared in both groups.

cervical plexus block

cervical plexus block PROCEDURE

In our study, one patient group will receive only general anesthesia, while the other group will receive general anesthesia in addition to ultrasound-guided cervical plexus block.

GENERAL ANESTHESIA

Eligibility Criteria

• Age: 18 Years - 70 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• This includes patients aged 18-70 years
• classified as ASA I-III
• who have undergone elective thyroidectomy.

You may not qualify if:

• Patients who did not wish to participate in the study voluntarily
• patients for whom superficial cervical block was contraindicated
• pregnant and breastfeeding women
• patients in ASA IV-V groups were excluded from the study.

Sponsors & Collaborators

• Harran University: lead

MeSH Terms

Interventions

Anesthesia, General; Cervical Plexus Block

Intervention Hierarchy (Ancestors)

Anesthesia; Anesthesia and Analgesia; Nerve Block; Anesthesia, Conduction

Central Study Contacts

Abdulhakim Şengel

CONTACT

+905374030916; ahsengel121@gmail.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: ANESTHESIA AND RESUSCITATION SPECIALIST

Study Record Dates

• First Submitted: April 20, 2026
• First Posted: May 18, 2026
• Study Start (Estimated): July 30, 2026
• Primary Completion (Estimated): February 20, 2027
• Study Completion (Estimated): February 20, 2027
• Last Updated: May 18, 2026

Record last verified: 2026-05

Data Sharing

• IPD Sharing: Will not share