Cervical Erector Spinae Plane Block vs Cervical Plexus Block in Controlling Acute Postoperative Pain After Thyroidectomy

NCT06974630 | Completed

• 1 other identifier: AP2411-501-102-193
• Study Type: interventional
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to compare the efficacy and safety of cervical erector spinae plane block vs. cervical plexus block in controlling acute postoperative pain after thyroidectomy.

Conditions

Cervical; Erector Spinae Plane Block; Cervical Plexus Block; Postoperative Pain; Thyroidectomy

Outcome Measures

Primary Outcomes (1)

• Total morphine consumption

  Rescue analgesia of morphine will be given as 3 mg bolus if the numeric rating scale (NRS) \> 3 to be repeated after 30 min if pain persists until the NRS \< 4.

  48 hours postoperatively

Secondary Outcomes (4)

• Time to the 1st rescue analgesia

  48 hours postoperatively

• Intraoperative fentanyl consumption

  Intraoperatively

• Degree of pain

  48 hours postoperatively

• Incidence of adverse events

  48 hours postoperatively

Study Arms (2)

ESPB group

EXPERIMENTAL

Patients will receive bilateral ultrasound-guided cervical erector spinae plane block using 15 ml of bupivacaine 0.25% on each side.

Other: Cervical erector spinae plane block

SCPB group

ACTIVE COMPARATOR

Patients will receive bilateral ultrasound-guided superficial cervical block using 15 mL of 0.25% plain bupivacaine on each side of the neck.

Other: Cervical plexus block

Interventions

Cervical erector spinae plane block OTHER

Patients will receive bilateral ultrasound-guided cervical erector spinae plane block using 15 ml of bupivacaine 0.25% on each side.

Also known as: Bupivacaine 0.25%

ESPB group

Cervical plexus block OTHER

Patients will receive bilateral ultrasound-guided superficial cervical block using 15 mL of 0.25% plain bupivacaine on each side of the neck.

Also known as: Bupivacaine 0.25%

SCPB group

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Age from 18 to 65 years.
• Both genders.
• American Society of Anesthesiologists (ASA) physical status I-II.
• Scheduled for either hemi- or total thyroidectomy.

You may not qualify if:

• Known allergy to local anesthetics.
• Allergy to all opioid medications.
• Pregnant patient.
• Previous neck surgery.
• Recent use of non-steroidal anti-inflammatory drugs (NSAIDs), opioids or steroid injection within 2 weeks.
• Those who cannot utilize the numeric rating scale (NRS) .
• Chronic opioid use.
• Coagulopathy.

Sponsors & Collaborators

• Cairo University: lead

Study Sites (1)

Cairo University

Cairo, 12613, Egypt

Location

MeSH Terms

Conditions

Pain, Postoperative

Interventions

Cervical Plexus Block

Condition Hierarchy (Ancestors)

Postoperative Complications; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Pain; Neurologic Manifestations; Signs and Symptoms

Intervention Hierarchy (Ancestors)

Nerve Block; Anesthesia, Conduction; Anesthesia; Anesthesia and Analgesia

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Lecturer of Anesthesia, Surgical ICU and Pain Management, Faculty of Medicine, National Cancer Institute, Cairo University, Egypt.

Study Record Dates

• First Submitted: May 8, 2025
• First Posted: May 16, 2025
• Study Start: May 15, 2025
• Primary Completion: November 30, 2025
• Study Completion: November 30, 2025
• Last Updated: December 29, 2025

Record last verified: 2025-12

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL
• Time Frame: After the end of study for one year.
• Access Criteria: The data will be available upon a reasonable request from the corresponding author.

Locations

EG (1)