Efficacy of Pulsed Electromagnetic Field Therapy on Women With Endometriosis

NCT07592403 | Recruiting

• 1 other identifier: PEMF IN ENDOMETRIOSIS 2026
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

This randomized, sham-controlled, double-blinded clinical trial aims to investigate the effects of pulsed electromagnetic field therapy (PEMF) on pain intensity, quality of life, and pelvic floor morphometric changes assessed by four-dimensional trans perineal ultrasound (4D TPUS) in women diagnosed with endometriosis. Participants will be randomly allocated into either a PEMF therapy group or a sham PEMF control group. Both groups will continue receiving stable standard medical care throughout the study period. Assessments will be conducted at baseline, after completion of the 8-week intervention period, and at 3-month follow-up.

Conditions

Endometriosis; Pulsed Electromagnetic Therapy; Trans Perineal Ultrasound

Keywords

Endometriosis; Pulsed Electromagnetic Field Therapy; trans perineal ultrasound

Outcome Measures

Primary Outcomes (1)

• Endometriosis Health Profile-30 (EHP-30) questionnaire

  The Endometriosis Health Profile-30 questionnaire will be used to assess disease-specific quality of life. The EHP-30 evaluates pain, emotional well-being, control and powerlessness, social support, and self-image. Scores are transformed to a scale ranging from 0 to 100, with higher scores indicating poorer health-related quality of life.

  Baseline, 8 weeks and at 3-month follow-up.

Secondary Outcomes (2)

• Trans-perineal Ultrasound Assessment

  Baseline, 8 weeks and 3-month follow-up.

• Pain Intensity scale (VAS)

  Baseline, 8 weeks and 3-month follow-up.

Study Arms (2)

Pulsed Electromagnetic Field Therapy Group

EXPERIMENTAL

Participants in this group will receive pulsed electromagnetic field therapy in addition to stable standard medical care.

Device: Pulsed Electromagnetic Field Therapy

Sham Pulsed Electromagnetic Field Therapy Group

SHAM COMPARATOR

Participants in this group will receive sham pulsed electromagnetic field therapy sessions in addition to stable standard medical care.

Device: Sham pulsed electromagnetic field therapy

Interventions

Pulsed Electromagnetic Field Therapy DEVICE

PEMF will be applied using a low-frequency pulsed electromagnetic stimulation device with sinusoidal waveform output targeting the lower abdominal and pelvic regions. Treatment sessions will be administered three times weekly for 8 consecutive weeks, with each session lasting approximately 20 minutes. Treatment parameters will include pulsed frequency ranging from 10 Hz, magnetic field intensity ranging from 2 mT, and pulse duration ranging from 250 microseconds. Standard medical care include stable hormonal therapy and prescribed analgesic medications without modification during the study period.

Pulsed Electromagnetic Field Therapy Group

Sham pulsed electromagnetic field therapy DEVICE

Participants in this group will receive sham pulsed electromagnetic field therapy sessions in addition to stable standard medical care. The sham device will appear identical to the active device in shape, sound, and operating indicators without delivering therapeutic electromagnetic output. Session duration, participant positioning, and treatment frequency will match those of the experimental group.

Sham Pulsed Electromagnetic Field Therapy Group

Eligibility Criteria

• Age: 18 Years - 45 Years
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Women aged 18 to 45 years
• Clinically, radiologically, or laparoscopically diagnosed endometriosis
• Chronic pelvic pain persisting for at least 6 months
• Stable pharmacological or hormonal treatment for at least 3 months before enrollment
• Ability to understand study procedures and provide written informed consent

You may not qualify if:

• Pregnancy or planned pregnancy during the study period
• History of gynecological or pelvic malignancy
• Active pelvic inflammatory disease or acute pelvic infection
• Implanted electronic medical devices such as pacemakers or neurostimulators
• Previous pelvic surgery within the past 6 months
• Participation in another clinical trial during the previous 3 months
• Neurological, rheumatological, or severe musculoskeletal disorders affecting assessment procedures
• Contraindications to electromagnetic therapy

Sponsors & Collaborators

• Beni-Suef University: lead

Study Sites (1)

Outpatient clinic, faculty of Physical Therapy, Beni Suef University

Banī Suwayf, Egypt

RECRUITING

MeSH Terms

Conditions

Endometriosis

Condition Hierarchy (Ancestors)

Genital Diseases, Female; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Genital Diseases

Central Study Contacts

Marwa Elsayed Mohamed Lecturer, Ph.D

CONTACT

01141825442; Marwa.elsayed@pt.bsu.edu.eg

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, OUTCOMES ASSESSOR
• Masking Details: Participants and outcome assessors will be blinded to group allocation. The sham device will appear identical to the active device in shape, sound, and operating indicators without delivering therapeutic electromagnetic output. Treating therapists will not participate in outcome assessment or data analysis.
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Lecturer of Physiotherapy for Women Health

Study Record Dates

• First Submitted: May 11, 2026
• First Posted: May 18, 2026
• Study Start: May 16, 2026
• Primary Completion (Estimated): January 20, 2027
• Study Completion (Estimated): January 30, 2027
• Last Updated: May 19, 2026

Record last verified: 2026-05

Locations

EG (1)