Effects of Dioscorea Yam Gruel on Blood Lipid Profiles in PCI Patients With Coronary Heart Disease

NCT07589036 | Completed

• 1 other identifier: 2026-05
• Study Type: interventional
• Target: 72
• Locations: 1 country
• Sites: 1

Brief Summary

This randomized controlled trial investigated the effects of Dioscorea yam gruel on blood lipid levels in patients with coronary heart disease after percutaneous coronary intervention (PCI). A total of 72 eligible post-PCI patients were randomly assigned to the control group or the intervention group. Patients in the control group received standard post-procedural treatment and care. In addition to this standard regimen, those in the intervention group were provided with approximately 150 g of Dioscorea yam gruel daily as a partial dinner replacement for 12 consecutive weeks. Serum levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), and body mass index (BMI) were measured at baseline, and at 8 weeks and 12 weeks of the intervention.

Conditions

PCI; Coronary Heart Disease (CHD)

Keywords

Dioscorea yam gruel; Coronary heart disease; Percutaneous coronary intervention; PCI; Blood lipids; Dietary therapy

Outcome Measures

Primary Outcomes (1)

• Blood Lipid Profile

  Serum levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG), and high-density lipoprotein cholesterol (HDL-C) were measured at baseline, 8 weeks, and 12 weeks of the intervention

  Baseline, Week 8, Week 12

Secondary Outcomes (1)

• Body Mass Index (BMI)

  Baseline, Week 12

Study Arms (2)

Standard Care Group

ACTIVE COMPARATOR

Patients received standard post-procedural treatment and care, including weekly health education lectures (1 hour each) and routine outpatient follow-up every 4 weeks

Other: Standard Post-PCI Care

Dioscorea Yam Gruel Group

EXPERIMENTAL

In addition to all interventions received by the control group, patients consumed approximately 150 g of Dioscorea yam gruel daily as a partial dinner replacement for 12 consecutive weeks

Dietary Supplement: Dioscorea Yam Gruel

Interventions

Standard Post-PCI Care OTHER

Standard post-procedural treatment and care including weekly health education lectures (1 hour each) and routine outpatient follow-up every 4 weeks

Standard Care Group

Dioscorea Yam Gruel DIETARY_SUPPLEMENT

In addition to receiving all standard post-PCI care (weekly health education lectures and routine 4-week follow-up), patients consumed approximately 150 g of Dioscorea yam gruel daily as a partial dinner replacement for 12 consecutive weeks

Dioscorea Yam Gruel Group

Eligibility Criteria

• Age: 18 Years - 75 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Meeting the diagnostic criteria for coronary heart disease (2020 edition)
• Undergoing percutaneous coronary intervention (PCI)
• Aged between 18 and 75 years
• Having been on a stable dose of statin therapy for at least 4 weeks prior to screening
• Being in a stable clinical condition, conscious, providing informed consent, and participating voluntarily

You may not qualify if:

• Low-density lipoprotein cholesterol (LDL-C) level \< 70 mg/dL(\<1.81mmol/L) at screening
• Complicating with other severe diseases or diseases that affect blood lipid levels, such as malignant tumors, acute cerebrovascular disease, nephrotic syndrome, severe liver disease, Cushing's syndrome, and others
• Pregnancy or lactation
• Concurrently participating in other dietary or exercise intervention programs

Sponsors & Collaborators

• 900th Hospital of PLA Joint Logistic Support Force: lead

Study Sites (1)

900th Hospital of PLA Joint Logistic Support Force

Fuzhou, Fujian, 350025, China

Location

MeSH Terms

Conditions

Coronary Disease

Condition Hierarchy (Ancestors)

Myocardial Ischemia; Heart Diseases; Cardiovascular Diseases; Vascular Diseases

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Masking Details: Participants and care providers were not blinded due to the nature of the dietary intervention. Outcome assessors and data analysts were blinded to group allocation throughout the trial
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Nurse-in-charge

Study Record Dates

• First Submitted: May 5, 2026
• First Posted: May 15, 2026
• Study Start: January 10, 2024
• Primary Completion: March 15, 2025
• Study Completion: March 15, 2025
• Last Updated: May 18, 2026

Record last verified: 2026-05

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)