China-NINE Cohort：Neuroimmune Network in Elderly / Neurodegeneration

NCT07586501 | Enrolling By Invitation

• 1 other identifier: X2026-001
• Study Type: observational
• Target: 260
• Locations: 1 country
• Sites: 2

Brief Summary

This is an observational study aimed at understanding the cognitive, functional, and behavioral characteristics of Chinese patients with cognitive impairment, exploring the underlying mechanisms, and providing evidence for early diagnosis, treatment, and care of cognitive disorders including dementia. Eligible participants will undergo a series of assessments and examinations, including cognitive and memory scale tests, routine blood tests, ApoE genetic testing, cerebrospinal fluid testing, brain MRI, functional MRI, and FDG-PET/AV45-PET scans when necessary. Additional samples such as saliva, nasal secretions, and stool may also be collected. Most evaluations are provided free of charge to support diagnosis and treatment guidance. Participation is voluntary. All personal information and research data will be kept confidential. Potential benefits include access to expert clinical care and free cognitive assessments for disease evaluation. Possible inconveniences include time commitment and temporary discomfort during examinations; medical support will be provided if needed.

Conditions

Cognitive Dysfunction, Cognitive Disorder; Parkinson's Disease (PD); Cognitive Dysfunction

Keywords

Cognitive impairment, dementia, Alzheimer's disease, biomarker, brain MRI, neuroimaging, cognitive assessment, elderly population; Parkinson's disease

Outcome Measures

Primary Outcomes (1)

• Degree and Type of Cognitive Impairment Assessed by Neuropsychological Scales

  Higher scores indicate better cognitive function; lower scores indicate more severe cognitive impairment.

  From enrollment to the end of treatment at 3 years

Eligibility Criteria

• Age: 55 Years - 75 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Participants were recruited from Yantai Yuhuangding Hospital, Yantai, Shandong Province, China.

You may qualify if:

• Participants with clinically diagnosed cognitive impairment. Patients with clinically diagnosed Parkinson's disease. Healthy control participants.

You may not qualify if:

• Central nervous system infection, head trauma, epilepsy, multiple sclerosis, or other major neurological disorders.
• Malignant tumors. Family history of genetic disorders.

Sponsors & Collaborators

• Yantai Yuhuangding Hospital: lead

Study Sites (2)

Yantai Yuhuangding Hospital

Yantai, Shandong, China

Location

Yantai Yuhuangding Hospital

Yantai, China

Location

Related Publications (1)

• McKhann GM, Knopman DS, Chertkow H, Hyman BT, Jack CR Jr, Kawas CH, Klunk WE, Koroshetz WJ, Manly JJ, Mayeux R, Mohs RC, Morris JC, Rossor MN, Scheltens P, Carrillo MC, Thies B, Weintraub S, Phelps CH. The diagnosis of dementia due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement. 2011 May;7(3):263-9. doi: 10.1016/j.jalz.2011.03.005. Epub 2011 Apr 21.

  PMID: 21514250 BACKGROUND

MeSH Terms

Conditions

Cognitive Dysfunction; Parkinson Disease; Dementia; Alzheimer Disease

Condition Hierarchy (Ancestors)

Cognition Disorders; Neurocognitive Disorders; Mental Disorders; Parkinsonian Disorders; Basal Ganglia Diseases; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Movement Disorders; Synucleinopathies; Neurodegenerative Diseases; Tauopathies

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Chief Physician, Department of Neurology

Study Record Dates

• First Submitted: May 6, 2026
• First Posted: May 14, 2026
• Study Start: January 16, 2026
• Primary Completion (Estimated): January 1, 2029
• Study Completion (Estimated): January 1, 2029
• Last Updated: May 14, 2026

Record last verified: 2026-05

Data Sharing

• IPD Sharing: Will not share

Locations

CN (2)