Eye Movement Parameters and Cognitive Functions in Older Adults

NCT07358598 | Not Yet Recruiting

• 1 other identifier: KSVGH24-CT10-11
• Study Type: observational
• Target: 210
• Locations: 1 country
• Sites: 1

Brief Summary

Dementia most commonly occurs in elderly individuals, but currently there is still a lack of objective measurement methods that can detect cognitive impairment in older adults at an early stage. Eye movement is considered a clinical indicator with potential for screening mild cognitive dysfunction, and eye movement signals can be extracted to objectively evaluate cognition. Eye tracking has been used mostly to evaluate patients with neurodegenerative diseases such as Parkinson's disease. However, less attention has been paid to the relationship between eye movement and cognitive function in elderly individuals, as well as the association between eye movement data and abnormal cognitive subdomains. This cross-sectional study will recruit 0204 elderly individuals over the age of 65, divided into three groups (healthy group/mild cognitive impairment group/dementia group) according to the purpose of this study. Participants who have not been diagnosed with neurological diseases (such as Parkinson's disease or stroke), or have mental illness or visual impairments will be excluded. This study hopes to provide empirical data on eye movement signals and cognitive function in healthy older individuals, as well as to serve as a preliminary study for future development of eye activity stimulation to improve cognitive function in older adults.

Conditions

Cognitive Dysfunction

Keywords

Eye movements; Cognitive function impairment; Older adults

Outcome Measures

Primary Outcomes (1)

• Eye-tracking measurement

  Eye movement behavior will be assessed as an objective measure of cognitive control in older adults. Eye-tracking data will be collected using the J7EF Gaze Smart Glasses (Jorjin Technologies), a non-invasive wearable eye-tracking system with a sampling frequency of 30 Hz. Participants will perform standardized visual tasks while eye movement behavior is recorded. Outcome measures will include task-related eye movement patterns, such as gaze behavior and saccadic performance, which reflect attentional control and higher-order cognitive processing. Alterations in these eye movement parameters have been associated with cognitive impairment. Eye movement measures will be used to characterize differences in cognitive function across participant groups.

  A single assessment is conducted at one study visit (cross-sectional design).

Secondary Outcomes (1)

• Mini-Mental State Examination (MMSE)

  A single assessment is conducted at one study visit (cross-sectional design).

Other Outcomes (6)

• Eye-Tracking Task 1: Horizontal Fixation Task (HFT)

  A single assessment is conducted at one study visit (cross-sectional design).

• Eye-Tracking Task 2: Vertical Fixation Task (VFT)

  A single assessment is conducted at one study visit (cross-sectional design).

• Eye-tracking Task 3: Horizontal Pursuit Task (HPT)

  A single assessment is conducted at one study visit (cross-sectional design).

Study Arms (3)

Healthy group-patients with intact cognitive function

Mild cognitive impairment group-patients with mild cognitive impairment

Dementia group-patients with severe cognitive impairment

Eligibility Criteria

• Age: 65 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

A total of 210 participants will be recruited, with an estimated 70 individuals in each cognitive group.

You may qualify if:

• \- Participants are aged 65 years or older and have completed a comprehensive geriatric assessment (CGA) in the outpatient clinic.

You may not qualify if:

• Participants are under 65 years of age or those who ar are unable to comply with study procedures.

Sponsors & Collaborators

• National Sun Yat-sen University: lead

Study Sites (1)

Kaohsiung Veterans General Hospital

Kaohsiung City, Taiwan

Location

Related Publications (1)

• Pereira ML, Camargo Mv, Aprahamian I, Forlenza OV. Eye movement analysis and cognitive processing: detecting indicators of conversion to Alzheimer's disease. Neuropsychiatr Dis Treat. 2014 Jul 9;10:1273-85. doi: 10.2147/NDT.S55371. eCollection 2014.

  PMID: 25031536 RESULT

MeSH Terms

Conditions

Cognitive Dysfunction

Condition Hierarchy (Ancestors)

Cognition Disorders; Neurocognitive Disorders; Mental Disorders

Central Study Contacts

Yen Chin CHEN, Associated professor

CONTACT

+886 7 5252000#7374; yenchin2427@gmail.com

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Target Duration: 1 Year
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 5, 2026
• First Posted: January 22, 2026
• Study Start: January 17, 2026
• Primary Completion (Estimated): December 31, 2026
• Study Completion (Estimated): December 31, 2026
• Last Updated: January 23, 2026

Record last verified: 2026-01

Data Sharing

• IPD Sharing: Will not share

Locations

TW (1)