Prospective Multicenter Screening for Thoracic Disease Via Radiography

NCT07585214 | Recruiting DMC

• 1 other identifier: PROMPT
• Study Type: observational
• Target: 300,000
• Locations: 1 country
• Sites: 1

Brief Summary

This multicenter, prospective study aims to evaluate the real-world clinical utility of chest X-ray (CXR) for large-scale thoracic disease screening. Adult participants presenting for health examinations will undergo digital CXR screening, and any suspected abnormalities will be confirmed via a gold standard reference, such as a chest CT scan or clinical follow-up. The primary outcome measure is the detection rate (screening yield) of confirmed thoracic conditions. Secondary measures will assess diagnostic accuracy (sensitivity and specificity), false-positive rates, and multi-center reading consistency. By providing prospective, large-cohort evidence, this research seeks to validate the cost-effectiveness and feasibility of CXR in identifying early-stage lung, pleural, and cardiac abnormalities, ultimately guiding public health strategies and optimizing early medical intervention.

Conditions

Pulmonary Diseases; Respiratory Disease; Esophageal Diseases

Keywords

PROMPT; Thoracic; Screen; Radiography; Multicenter; Prospective

Outcome Measures

Primary Outcomes (2)

• Overall Detection Rate of Thoracic Diseases

  Defined as the proportion of subjects with positive X-ray findings that are subsequently confirmed by a gold standard reference (e.g., CT scan, pathology, or comprehensive clinical follow-up) out of the total screened population.

  Through study completion, an average of 1 year.

• Screening Yield

  Defined as the number of newly identified, clinically significant thoracic disease cases detected per 1,000 screening examinations.

  Through study completion, an average of 1 year.

Secondary Outcomes (3)

• Diagnostic Performance Metrics

  Through study completion, an average of 1 year.

• Multi-center Consistency and Inter-reader Reliability

  Through study completion, an average of 1 year.

• Disease-Specific Detection Rates

  Through study completion, an average of 1 year.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Participants who received radiography for thoracic disease screen.

You may qualify if:

• Age over 18.
• Ability to understand and willingness to sign a written informed consent form.
• Individuals presenting for routine health examinations or community-based screening.

You may not qualify if:

• Women who are pregnant, lactating, or planning to become pregnant during the study period.
• Physical limitations preventing stable positioning or breath-holding, or presence of metallic implants that may significantly degrade image quality.
• Known history of advanced thoracic diseases currently under treatment (e.g., active lung cancer, end-stage pulmonary fibrosis, or congestive heart failure).
• Individuals who have undergone chest CT or X-ray examinations within the past 3 months.

Sponsors & Collaborators

• Chinese Academy of Sciences: lead

Study Sites (1)

Dazhou Central Hospital

Dazhou, Sichuan, China

RECRUITING

MeSH Terms

Conditions

Lung Diseases; Respiration Disorders; Esophageal Diseases

Condition Hierarchy (Ancestors)

Respiratory Tract Diseases; Gastrointestinal Diseases; Digestive System Diseases

Central Study Contacts

Zeyu Zhang, Ph.D.

CONTACT

+86 15510661612; zhangzeyu@fingerpass.net.cn

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 5 Years
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: May 4, 2026
• First Posted: May 13, 2026
• Study Start: May 1, 2026
• Primary Completion (Estimated): December 31, 2028
• Study Completion (Estimated): December 31, 2029
• Last Updated: May 13, 2026

Record last verified: 2026-05

Locations

CN (1)