Evaluation of Diagnosis and Treatment Methods in Corrosive Esophagitis: A 26-Year Experience-Based Algorithm

NCT06816758 | Completed

• 1 other identifier: B.30.2.ODM.0.20.08/800
• Study Type: observational
• Target: 501
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to evaluate the diagnosis and treatment methods for corrosive esophagitis based on 26 years of clinical experience. It will retrospectively analyze patient records to identify patterns in clinical outcomes, complications, and the effectiveness of treatment strategies. The study focuses on optimizing patient care by proposing a diagnosis and treatment algorithm that can guide future clinical practices. Data will be collected from hospital archives and electronic health records, covering cases of corrosive esophagitis managed at Ondokuz Mayıs University between 1998 and 2024.

Conditions

Esophageal Diseases

Outcome Measures

Primary Outcomes (1)

• Incidence of Esophageal Stricture, Perforation, and Other Related Complications

  The number of patients who develop esophageal strictures, perforation, or other complications within 1 month post-admission will be recorded.

  Within 1 month after hospital admission

Interventions

Routine Care for Corrosive Esophagitis OTHER

This is an observational study, so participants are not assigned interventions. However, the study investigates the outcomes of patients diagnosed with corrosive esophagitis who received routine clinical care. The exposure of interest includes diagnostic and treatment procedures such as endoscopic evaluation (Zargar classification), proton pump inhibitors, corticosteroid therapy, and surgical interventions for complications like strictures. The outcomes and clinical data collected reflect routine care practices over 26 years.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

This study focuses on patients diagnosed with corrosive esophagitis due to the ingestion of corrosive substances. The population includes individuals aged over 18 years who were hospitalized and treated at Ondokuz Mayıs University Thoracic Surgery Department between 1998 and 2024. The patients underwent clinical, laboratory, and radiological evaluations, and their outcomes were assessed retrospectively.

You may qualify if:

• Patients diagnosed with corrosive esophagitis due to corrosive substance ingestion.
• Hospitalized and treated at Ondokuz Mayıs University Thoracic Surgery Department.
• Patients who underwent clinical, laboratory, and radiological evaluations to confirm the diagnosis.
• Patients who were monitored and met follow-up criteria during their treatment.
• Patients above 18 years of age

You may not qualify if:

• Patients under 18 years of age.
• Patients who refused hospitalization or treatment.
• Patients who ingested non-corrosive or non-toxic substances (verified by the Ministry of Health Poison Information Center).
• Patients lost to follow-up or did not complete follow-up requirements.
• Patients with incomplete data during the diagnostic or treatment process.

Sponsors & Collaborators

• Caner İşevi, MD: lead

Study Sites (1)

Ondokuz Mayıs University Faculty of Medicine

Samsun, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Esophageal Diseases

Condition Hierarchy (Ancestors)

Gastrointestinal Diseases; Digestive System Diseases

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: January 27, 2025
• First Posted: February 10, 2025
• Study Start: May 1, 2025
• Primary Completion: May 10, 2025
• Study Completion: May 15, 2025
• Last Updated: May 21, 2025

Record last verified: 2025-01

Data Sharing

• IPD Sharing: Will share

Locations

TU (1)