Evaluation of the Administration of Artificial Nutrition by Feeding Jejunostomy During Neoadjuvant Treatment on Postoperative Morbidity in the Context of Esophageal or Stomach Cancer

NCT07584577 | Recruiting

• 1 other identifier: CHUBX 2025/060
• Study Type: observational
• Target: 670
• Locations: 1 country
• Sites: 1

Brief Summary

Malnutrition is common at the time of diagnosis of esogastric cancers. However, there are no recommendations regarding preoperative nutritional support (type and duration) or on the impact of refeeding on postoperative morbidity and mortality.

Conditions

Esophageal Cancer; Surgery Indication; Malnourished; Neoadjuvant Treatment

Outcome Measures

Primary Outcomes (1)

• Rate of postoperative complications according to the Clavien classification

  Proportion of patients experiencing at least one postoperative complication, classified according to Clavien-Dindo, in malnourished patients with versus without nutritional support.

  Day 30

Study Arms (2)

Control group

patients who did not receive enteral or parenteral nutrition during neoadjuvant treatment.

Case group

patients who received enteral or parenteral nutrition during neoadjuvant treatment.

Dietary Supplement: Enteral or parenteral nutrition

Interventions

Enteral or parenteral nutrition DIETARY_SUPPLEMENT

Patients who did not receive enteral or parenteral nutrition during neoadjuvant treatment.

Case group

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Retrospective case-control study including patients with esophageal cancer treated with neoadjuvant therapy. The control group consists of patients who did not receive enteral or parenteral nutrition during neoadjuvant treatment. The case group consists of patients who received enteral or parenteral nutrition during neoadjuvant treatment.

You may qualify if:

• Patient undergoing surgery for esophageal cancer
• Malnourished patient at the time of management
• Receiving neoadjuvant treatment

You may not qualify if:

• Patient not malnourished at the time of management
• Patient who did not receive neoadjuvant treatment

Sponsors & Collaborators

• University Hospital, Bordeaux: lead
• French Eso-Gastric Tumors Working Group: collaborator

Study Sites (1)

Hopîtal du Haut Lévêque

Pessac, 33600, France

RECRUITING

Related Publications (3)

• Mariette C, De Botton ML, Piessen G. Surgery in esophageal and gastric cancer patients: what is the role for nutrition support in your daily practice? Ann Surg Oncol. 2012 Jul;19(7):2128-34. doi: 10.1245/s10434-012-2225-6. Epub 2012 Feb 10.

  PMID: 22322948 BACKGROUND

• Deftereos I, Kiss N, Isenring E, Carter VM, Yeung JM. A systematic review of the effect of preoperative nutrition support on nutritional status and treatment outcomes in upper gastrointestinal cancer resection. Eur J Surg Oncol. 2020 Aug;46(8):1423-1434. doi: 10.1016/j.ejso.2020.04.008. Epub 2020 Apr 18.

  PMID: 32336624 BACKGROUND

• Deftereos I, Yeung JM, Arslan J, Carter VM, Isenring E, Kiss N, On Behalf Of The Nourish Point Prevalence Study Group. Preoperative Nutrition Intervention in Patients Undergoing Resection for Upper Gastrointestinal Cancer: Results from the Multi-Centre NOURISH Point Prevalence Study. Nutrients. 2021 Sep 15;13(9):3205. doi: 10.3390/nu13093205.

  PMID: 34579082 BACKGROUND

MeSH Terms

Conditions

Esophageal Neoplasms; Malnutrition

Interventions

Parenteral Nutrition

Condition Hierarchy (Ancestors)

Gastrointestinal Neoplasms; Digestive System Neoplasms; Neoplasms by Site; Neoplasms; Head and Neck Neoplasms; Digestive System Diseases; Esophageal Diseases; Gastrointestinal Diseases; Nutrition Disorders; Nutritional and Metabolic Diseases

Intervention Hierarchy (Ancestors)

Feeding Methods; Therapeutics; Nutritional Support; Nutrition Therapy

Study Officials

• Caroline GRONNIER, MD, PhD

  University Hospital, Bordeaux

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Caroline GRONNIER, PhD, MD

CONTACT

+335-57-62-24-77; caroline.gronnier@chu-bordeaux.fr

Valérie AURILLAC

CONTACT

+335-57-62-24-77; valerie.aurillac@chu-bordeaux.fr

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 19, 2025
• First Posted: May 13, 2026
• Study Start (Estimated): November 1, 2026
• Primary Completion (Estimated): November 30, 2026
• Study Completion (Estimated): November 30, 2026
• Last Updated: May 13, 2026

Record last verified: 2026-05

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, SAP

Locations

FR (1)