DELAYED VERSUS EARLY SURGICAL DECOMPRESSION FOR TRAUMATIC SPINAL CORD INJURY

NCT07583836 | Recruiting

• 1 other identifier: 999/RC/FFH/RWP
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

To compare the outcome of early versus delayed surgical decompression among patients presenting with traumatic spinal cord injury in a tertiary care hospital.

Conditions

Traumatic Spinal Cord Injury

Keywords

Traumatic Spinal Cord Injury

Outcome Measures

Primary Outcomes (1)

• improvement in neurological impairment using ASIA Impairment Scale (AIS)

  Treatment outcomes will be measured 12 weeks after early or delayed surgical decompression among all the patients who underwent spinal cord injury in terms of improvement in neurological impairment using ASIA Impairment Scale (AIS) attached as annexure-C. Outcome will be labelled as good if shows improvement for at least two AIS grades.

  12 Weeks after surgery

Interventions

Early Surgical Decompression PROCEDURE

it will be defined as the surgical decompression performed within 24 hours of injury. It will be performed among all the patients who presented within 24 hours of injury.

Delayed Surgical Decompression PROCEDURE

It will be defined as the surgical decompression performed after 24 hours of spinal cord injury. It will be performed among all the patients who needed it due to medical optimization (such as hemodynamically unstable, shock, pulmonary contusions, cerebrovascular destabilization etc.) or those who will present after 24 hours of injury due to logistical delay.

Eligibility Criteria

• Age: 18 Years - 60 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

• Patients presenting with spinal cord injury (both cervical and thoracic)

You may qualify if:

• Patients presenting with spinal cord injury (both cervical and thoracic) as per described in the operational definition
• Age from 18-60 years
• Both male and female patients

You may not qualify if:

• Patients with penetrating spinal injuries such as gunshot/stab wounds
• Patients with pre-existing neurological conditions like myelopathy etc.
• Patients with any kind of malignancy
• Patients having CSF infection etc.
• Patients who are not fit for general anesthesia (i.e. ASA Grade \>2 Annexure-B)
• Diagnosis of subclinical or clinical polyneuropathy
• Non-traumatic or pathological fractures or cord compression
• Inability to cooperate with preoperative physical examination because of cognitive impairment
• Patients with previous spinal column or SCI.

Sponsors & Collaborators

• Fauji Foundation Hospital: lead

Study Sites (1)

Fauji Foundation Hospital, Rawalpindi

Rawalpindi, Pakistan

RECRUITING

Central Study Contacts

Dr. Salman Tahir, MBBS

CONTACT

+92 322 6192355; ffh.rawalpindi@fauji.org.pk

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 7, 2026
• First Posted: May 13, 2026
• Study Start: August 30, 2025
• Primary Completion: March 1, 2026
• Study Completion: June 1, 2026
• Last Updated: May 13, 2026

Record last verified: 2026-05

Locations

PA (1)