Labor Epidural Analgesia and Mother-Infant Bonding After Vaginal Delivery

NCT07582289 | Not Yet Recruiting

• 2 other identifiers: B.30.2.ATA.0.01.00/2342026/2
• Study Type: observational
• Target: 140
• Locations: 1 country
• Sites: 1

Brief Summary

This prospective observational cohort study aims to evaluate the association between postpartum recovery quality and mother-infant bonding in women undergoing vaginal delivery. Postpartum recovery quality will be assessed using the Obstetric Quality of Recovery-10 (ObsQoR-10) questionnaire, and mother-infant bonding will be evaluated using the Postpartum Bonding Questionnaire (PBQ). Participants will be grouped according to routine clinical labor analgesia preference: women receiving labor epidural analgesia and women not receiving epidural analgesia. Additional assessments will include postpartum pain intensity, anxiety, depressive symptoms, and birth satisfaction. Baseline psychological assessments will be performed before delivery. The primary postpartum evaluation will be conducted between 6 and 24 hours after delivery. Exploratory follow-up assessments will be performed by telephone during postpartum week 2. The study aims to better understand the relationship between labor analgesia, postpartum recovery, and early mother-infant bonding outcomes after vaginal delivery.

Conditions

Postpartum Recovery; Mother-infant Bonding; Labor Pain

Keywords

Labor Epidural Analgesia; Postpartum Bonding Questionnaire; PBQ; EPDS; STAIS-5; ObsQoR-10; Vaginal Birth; Postpartum Recovery; Maternal Bonding; Obstetric Anesthesia; Postpartum Anxiety; Postpartum Depression

Outcome Measures

Primary Outcomes (1)

• Mother-Infant Bonding Score

  Mother-infant bonding will be assessed using the Postpartum Bonding Questionnaire (PBQ). Lower PBQ scores indicate better mother-infant bonding.

  6 to 24 hours after vaginal delivery

Secondary Outcomes (7)

• Postpartum Recovery Quality Score

  6 to 24 hours after vaginal delivery

• Postpartum Pain Intensity

  6 to 24 hours after vaginal delivery

• Postpartum Anxiety Level

  6 to 24 hours after vaginal delivery

• Postpartum Depressive Symptoms

  6 to 24 hours after vaginal delivery

• Birth Satisfaction Score

  6 to 24 hours after vaginal delivery

Study Arms (2)

Labor Epidural Analgesia

Women undergoing vaginal delivery with labor epidural analgesia as part of routine clinical care. Participants will undergo postpartum recovery, mother-infant bonding, anxiety, depression, pain, and birth satisfaction assessments during the postpartum period.

Procedure: Labor Epidural Analgesia

No Labor Epidural Analgesia

Women undergoing vaginal delivery without labor epidural analgesia as part of routine clinical care. Participants will be evaluated for postpartum recovery quality, mother-infant bonding, anxiety, depressive symptoms, pain intensity, and birth satisfaction during the postpartum period.

Interventions

Labor Epidural Analgesia PROCEDURE

Epidural analgesia administered during labor as part of routine clinical care for pain management during vaginal delivery.

Labor Epidural Analgesia

Eligibility Criteria

• Age: 18 Years - 40 Years
• Gender Eligibility Details: Female participants with term singleton pregnancy planning vaginal delivery are eligible for participation in the study.
• Healthy Volunteers: No
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Women with term singleton pregnancy planning vaginal delivery at Atatürk University Research Hospital will be enrolled. Participants will be grouped according to routine clinical labor epidural analgesia preference.

You may qualify if:

• Female participants aged 18 to 40 years
• Term singleton pregnancy (≥37 weeks)
• Planned vaginal delivery
• ASA physical status II
• Ability to understand Turkish
• Written informed consent

You may not qualify if:

• Contraindications to epidural analgesia including coagulopathy, anticoagulant use, infection, or increased intracranial pressure
• Cesarean delivery
• High-risk pregnancy
• Neonatal intensive care unit requirement
• Major depressive disorder
• Anxiety disorder
• Current psychotropic medication use

Sponsors & Collaborators

• Ataturk University: lead

Study Sites (1)

Ataturk University

Erzurum, 25000, Turkey (Türkiye)

Location

Related Publications (17)

• Doner S, Efe YS, Elmali F. Turkish adaptation of the state-trait anxiety inventory short version (STAIS-5, STAIT-5). Int J Nurs Pract. 2024 Dec;30(6):e13304. doi: 10.1111/ijn.13304. Epub 2024 Sep 25.

  PMID: 39323115 BACKGROUND

• Cox JL, Holden JM, Sagovsky R. Detection of postnatal depression. Development of the 10-item Edinburgh Postnatal Depression Scale. Br J Psychiatry. 1987 Jun;150:782-6. doi: 10.1192/bjp.150.6.782.

  PMID: 3651732 BACKGROUND

• Aydin N, Inandi T, Yigit A, Hodoglugil NN. Validation of the Turkish version of the Edinburgh Postnatal Depression Scale among women within their first postpartum year. Soc Psychiatry Psychiatr Epidemiol. 2004 Jun;39(6):483-6. doi: 10.1007/s00127-004-0770-4.

  PMID: 15205733 BACKGROUND

• Brockington IF, Oates J, George S, et al. A screening questionnaire for mother-infant bonding disorders. Archives of Women's Mental Health. 2001;3(4):133-140. doi:10.1007/s007370170010

  BACKGROUND

• Dissiz M, Bayri Bingol F, Demirgoz Bal M, Karacam Yilmaz ZD, Karakoc A, Bilgin Z. The Turkish version of the Postpartum Bonding Questionnaire (PBQ): Examination of the validity and reliability and scale structure. J Pediatr Nurs. 2024 Jul-Aug;77:131-139. doi: 10.1016/j.pedn.2024.03.012. Epub 2024 Mar 21.

  PMID: 38518689 BACKGROUND

• Bell AF, Andersson E. The birth experience and women's postnatal depression: A systematic review. Midwifery. 2016 Aug;39:112-23. doi: 10.1016/j.midw.2016.04.014. Epub 2016 May 7.

  PMID: 27321728 BACKGROUND

• Waldenstrom U. Women's memory of childbirth at two months and one year after the birth. Birth. 2003 Dec;30(4):248-54. doi: 10.1046/j.1523-536x.2003.00254.x.

  PMID: 14992155 BACKGROUND

• Hodnett ED. Pain and women's satisfaction with the experience of childbirth: a systematic review. Am J Obstet Gynecol. 2002 May;186(5 Suppl Nature):S160-72. doi: 10.1067/mob.2002.121141.

  PMID: 12011880 BACKGROUND

• Labor S, Maguire S. The Pain of Labour. Rev Pain. 2008 Dec;2(2):15-9. doi: 10.1177/204946370800200205.

  PMID: 26526404 BACKGROUND

• Anim-Somuah M, Smyth RM, Cyna AM, Cuthbert A. Epidural versus non-epidural or no analgesia for pain management in labour. Cochrane Database Syst Rev. 2018 May 21;5(5):CD000331. doi: 10.1002/14651858.CD000331.pub4.

  PMID: 29781504 BACKGROUND

• Lowe NK. The nature of labor pain. Am J Obstet Gynecol. 2002 May;186(5 Suppl Nature):S16-24. doi: 10.1067/mob.2002.121427.

  PMID: 12011870 BACKGROUND

• Simkin P. Just another day in a woman's life? Women's long-term perceptions of their first birth experience. Part I. Birth. 1991 Dec;18(4):203-10. doi: 10.1111/j.1523-536x.1991.tb00103.x.

  PMID: 1764149 BACKGROUND

• Feldman R. Mother-infant synchrony and the development of moral orientation in childhood and adolescence: direct and indirect mechanisms of developmental continuity. Am J Orthopsychiatry. 2007 Oct;77(4):582-97. doi: 10.1037/0002-9432.77.4.582.

  PMID: 18194038 BACKGROUND

• Brockington IF, Fraser C, Wilson D. The Postpartum Bonding Questionnaire: a validation. Arch Womens Ment Health. 2006 Sep;9(5):233-42. doi: 10.1007/s00737-006-0132-1. Epub 2006 May 4.

  PMID: 16673041 BACKGROUND

• Sultan P, Kamath N, Carvalho B, Bansal P, Elkhateb R, Dougan S, Whittington J, Guo N, El-Sayed Y, Mhyre J, Sharawi N. Evaluation of inpatient postpartum recovery using the Obstetric Quality of Recovery-10 patient-reported outcome measure: a single-center observational study. Am J Obstet Gynecol MFM. 2020 Nov;2(4):100202. doi: 10.1016/j.ajogmf.2020.100202. Epub 2020 Aug 17.

  PMID: 33345919 BACKGROUND

• Ciechanowicz S, Setty T, Robson E, Sathasivam C, Chazapis M, Dick J, Carvalho B, Sultan P. Development and evaluation of an obstetric quality-of-recovery score (ObsQoR-11) after elective Caesarean delivery. Br J Anaesth. 2019 Jan;122(1):69-78. doi: 10.1016/j.bja.2018.06.011. Epub 2018 Jul 31.

  PMID: 30579408 BACKGROUND

• Bowyer A, Royse C. The importance of postoperative quality of recovery: influences, assessment, and clinical and prognostic implications. Can J Anaesth. 2016 Feb;63(2):176-83. doi: 10.1007/s12630-015-0508-7.

  PMID: 26475163 BACKGROUND

MeSH Terms

Conditions

Labor Pain; Depression, Postpartum

Condition Hierarchy (Ancestors)

Pain; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Puerperal Disorders; Pregnancy Complications; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Depressive Disorder; Mood Disorders; Mental Disorders

Study Officials

• Ayşe Ceren Hilal Güven, assistant doctor

  Ataturk University Department of Anesthesiology and Reanimation

  STUDY CHAIR

Central Study Contacts

Ayşenur Dostbil, Associate Professor

CONTACT

+90 533 367 66 96; adostbil@hotmail.com

Ayşe Ceren Hilal Güven, assistant doctor

CONTACT

+90 554 112 25 81; achg1995@gmail.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor as the Principal Investigator

Study Record Dates

• First Submitted: May 6, 2026
• First Posted: May 12, 2026
• Study Start: May 15, 2026
• Primary Completion (Estimated): June 16, 2029
• Study Completion (Estimated): June 17, 2029
• Last Updated: May 12, 2026

Record last verified: 2026-05

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)