Ultrasound in Predicting Difficult Intubation in Acromegaly Patients

NCT07306325 | Not Yet Recruiting

• 1 other identifier: BSH-RG-Difficult Intubation
• Study Type: observational
• Target: 34
• Locations: 1 country
• Sites: 1

Brief Summary

This is a prospective observational study.The purpose of this study is to predict difficult intubation with ultrasonographic evaluation combined with preoperative physical examination in patients diagnosed with acromegaly and planned for pituitary surgery.

Conditions

Acromegaly Due to Pituitary Adenoma; Difficult Intubation; Airway Ultrasonography

Keywords

difficult intubation; acromegaly; airway ultrasonography

Outcome Measures

Primary Outcomes (3)

• Airway Ultrasonography

  Sonoatomonic evaluation of the airway and determination of difficult intubation in participants diagnosed with acromegaly and planned for pituitary surgery. - Distance Between Skin-Hyoid Bone (centimeters):

  one year

• Airway Ultrasonography

  Sonoatomonic evaluation of the airway and determination of difficult intubation in participants diagnosed with acromegaly and planned for pituitary surgery. - Distance Between Skin-Epiglottis (centimeters):

  one year

• Airway Ultrasonography

  Sonoatomonic evaluation of the airway and determination of difficult intubation in participants diagnosed with acromegaly and planned for pituitary surgery. - Distance Between Skin-Vocal Cord Anterior Commissure (centimeters)

  one year

Secondary Outcomes (11)

• preoperative physical examination

  one year

• preoperative physical examination

  one year

• preoperative physical examination

  one year

• preoperative physical examination

  one year

• preoperative physical examination

  one year

Study Arms (1)

Participants diagnosed with acromegaly

All ultrasonographic assessments will be performed preoperatively by anesthesiologists who have prior experience using ultrasound. Participants will be positioned in the supine position with the head and neck in neutral alignment. Measurements of the skin-hyoid bone, skin-epiglottis, and skin-anterior commissure of the vocal cords distances will be. Endotracheal intubation of the participants will be performed by anesthesiologists who are unfamiliar with the ultrasonographic measurements. During the intubation, the use of adjuncts, the need for cricoid pressure, the number of additional interventions, the number of additional operators, and the glottic opening seen during laryngoscopy will be recorded according to the Cormack-Lehane classification without external pressure. If necessary, advanced airway devices (videolaryngoscopy, flexible fiberoptic laryngoscopy) will be used.

Other: observational study

Interventions

observational study OTHER

In participants diagnosed with acromegaly, every patient to whom USG measurement methods are applied is followed by researchers before, during and after anesthesia applications, whether or not they are included in any study . Routine treatments that participants need will be fully implemented. Preoperative, intraoperative and postoperative follow-up data, which will be recorded observationally, will be used in this study.

Participants diagnosed with acromegaly

Eligibility Criteria

• Age: 18 Years - 70 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients between the ages of 18-70, regardless of gender, who are scheduled for endoscopic pituitary surgery at Başakşehir Çam and Sakura City Hospital Neurosurgery Clinic, will be included.

You may qualify if:

• Patients diagnosed with acromegaly who are planned for endoscopic pituitary surgery
• Volunteer participants
• American Society of Anesthesiology - ASA 1, 2 and 3 patient groups
• Patients with BMI\<40

You may not qualify if:

• ASA 4 patient group
• History of previous neck surgery
• Patients with a history of tracheostomy
• Patients with a history of radiotherapy to the neck area
• Patients with limited neck extension (rheumatological - traumatic reasons)
• Patients with masses and lesions in the mouth and airway that may make intubation difficult.

Sponsors & Collaborators

• Başakşehir Çam & Sakura City Hospital: lead

Study Sites (1)

Başakşehir Çam ve Sakura Hastanesi

Istanbul, Istanbul, 34480, Turkey (Türkiye)

Location

Related Publications (3)

• Apfelbaum JL, Hagberg CA, Connis RT, Abdelmalak BB, Agarkar M, Dutton RP, Fiadjoe JE, Greif R, Klock PA, Mercier D, Myatra SN, O'Sullivan EP, Rosenblatt WH, Sorbello M, Tung A. 2022 American Society of Anesthesiologists Practice Guidelines for Management of the Difficult Airway. Anesthesiology. 2022 Jan 1;136(1):31-81. doi: 10.1097/ALN.0000000000004002.

  PMID: 34762729 BACKGROUND

• Kasinath MPR, Rastogi A, Priya V, Singh TK, Mishra P, Pant KC. Comparison of Airway Ultrasound Indices and Clinical Assessment for the Prediction of Difficult Laryngoscopy in Elective Surgical Patients: A Prospective Observational Study. Anesth Essays Res. 2021 Jan-Mar;15(1):51-56. doi: 10.4103/aer.aer_75_21. Epub 2021 Aug 30.

  PMID: 34667348 BACKGROUND

• Rao S, Paliwal N, Saharan S, Bihani P, Jaju R, Sharma UD, Sharma M. A Comparative Study to Evaluate Difficult Intubation Using Ratio of Patient Height to Thyromental Distance, Ratio of Neck Circumference to Thyromental Distance and Thyromental Height in Adult Patients in Tertiary Care Centre. Turk J Anaesthesiol Reanim. 2023 Apr;51(2):90-96. doi: 10.5152/TJAR.2022.22077.

  PMID: 37140573 BACKGROUND

Related Links

• Related Info

MeSH Terms

Conditions

Growth Hormone-Secreting Pituitary Adenoma; Acromegaly

Interventions

Observation

Condition Hierarchy (Ancestors)

Adenoma; Neoplasms, Glandular and Epithelial; Neoplasms by Histologic Type; Neoplasms; Pituitary Neoplasms; Endocrine Gland Neoplasms; Neoplasms by Site; Pituitary Diseases; Hypothalamic Diseases; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Endocrine System Diseases; Bone Diseases, Endocrine; Bone Diseases; Musculoskeletal Diseases; Hyperpituitarism

Intervention Hierarchy (Ancestors)

Methods; Investigative Techniques

Central Study Contacts

Muzaffer Gencer

CONTACT

00905059436459; dr.m.gencer07@gmail.com

Rabia Genç

CONTACT

00905359831528; rabiagenc52@hotmail.com

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor Doctor

Study Record Dates

• First Submitted: November 24, 2024
• First Posted: December 29, 2025
• Study Start: December 25, 2025
• Primary Completion: March 20, 2026
• Study Completion: March 20, 2026
• Last Updated: December 29, 2025

Record last verified: 2025-12

Locations

TU (1)