Effects of Photobiomodulation in Hemophilia Patients.

NCT07579585 | Recruiting

• 1 other identifier: Zaira Zeeshan
• Study Type: interventional
• Target: 24
• Locations: 1 country
• Sites: 1

Brief Summary

Hemophilia is a genetic bleeding disorder that commonly leads to knee hemarthrosis, causing pain, swelling, and reduced joint mobility in children. While standard treatments include clotting factor replacement and physiotherapy, additional non-invasive approaches are being explored. This study aims to evaluate the effects of photobiomodulation on knee hemarthrosis in male hemophilia patients aged 9-14 years. It focuses on determining whether this therapy can reduce pain and swelling and improve joint range of motion when used alongside

Conditions

Hemarthrosis, Knee; Hemophilia

Keywords

Photobiomodulation; Hemarthrosis; Hemophilia

Outcome Measures

Primary Outcomes (3)

• VAS

  The Visual Analogue Scale (VAS) is a simple and widely used tool to measure a person's pain intensity. It typically consists of a 10 cm straight line, where: One end represents "no pain" (0) The other end represents "worst possible pain" (10) The patient is asked to mark a point on the line that best represents their level of pain. The distance from the "no pain" end to the marked point is then measured and recorded as the pain score. VAS is easy to use, quick, and effective for tracking changes in pain over time in both clinical and research settings.

  3rd Day

• Measuring Tape

  A measuring tape in physiotherapy is a simple, flexible tool used to assess body dimensions such as limb length, girth, and joint swelling. It helps therapists monitor changes over time, evaluate muscle atrophy or edema, and track patient progress during rehabilitation.

  3rd Day

• Goniometer

  A goniometer is a scientific instrument used to measure angles. It is commonly used in fields like geometry, engineering, and healthcare. In medicine-especially in physical therapy and orthopedics-it helps measure the range of motion of joints in the human body. A typical goniometer consists of a protractor-like scale with two arms that can be aligned along the body part or object to determine the angle accurately.

  3rd Day

Study Arms (1)

photobiomodulation

EXPERIMENTAL

The intervention involves the application of low-level laser therapy (LLLT), also referred to as photobiomodulation (PBM), using a diode laser device with the intensity in the range of 1 to 500 mW . The laser was applied in continuous-wave mode directly to the skin over the knee joint at multiple anatomical points, including the medial, lateral, superior, and inferior aspects of the patella, covering 8 to 9 specific locations. Total treatment time will be 10 minutes, delivered with a spot size 13 Effects of Photobiomodulation o knee hemarthosis in children with Hemophilia ranging from 0.04 to 0.07 cm². During the procedure, patients are positioned in a supine posture with the knee slightly flexed (20-30°) to allow optimal access to the target areas.

Radiation: photobiomodulation

Interventions

photobiomodulation RADIATION

Photobiomodulation is a non-invasive therapy that uses low-level light (typically from lasers or LEDs) to stimulate cellular activity and promote healing. It works by enhancing mitochondrial function, increasing energy (ATP) production, and reducing inflammation. This therapy is commonly used for pain relief, tissue repair, and improving recovery in various clinical conditions.

photobiomodulation

Eligibility Criteria

• Age: 9 Years - 14 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17)

You may qualify if:

• Hemophilia patients with knee hemarthosis
• Patients of age 9-14 yrs will be taken
• Bothmaleand female population will be included

You may not qualify if:

• Presence of open wounds at or near the treatment site.
• Kneejoint subluxation.
• Presence of congenital or acquired skeletal deformities.
• Children diagnosed with cardiopulmonary dysfunctions.
• Children with neurological deficits

Sponsors & Collaborators

• Riphah International University: lead

Study Sites (1)

Sundas Foundation

Sialkot, Punjab Province, 5100, Pakistan

RECRUITING

Related Publications (1)

• Laccourreye O, Maisonneuve H. French scientific medical journals confronted by developments in medical writing and the transformation of the medical press. Eur Ann Otorhinolaryngol Head Neck Dis. 2019 Nov;136(6):475-480. doi: 10.1016/j.anorl.2019.09.002. Epub 2019 Sep 17.

  PMID: 31540851 BACKGROUND

MeSH Terms

Conditions

Hemarthrosis; Hemophilia A

Interventions

Low-Level Light Therapy

Condition Hierarchy (Ancestors)

Joint Diseases; Musculoskeletal Diseases; Hemorrhage; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Blood Coagulation Disorders, Inherited; Blood Coagulation Disorders; Hematologic Diseases; Hemic and Lymphatic Diseases; Coagulation Protein Disorders; Hemorrhagic Disorders; Genetic Diseases, Inborn; Congenital, Hereditary, and Neonatal Diseases and Abnormalities

Intervention Hierarchy (Ancestors)

Laser Therapy; Therapeutics; Phototherapy

Study Officials

• Zaira Zeeshan, MS

  Riphah International University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Imran Amjad, PhD

CONTACT

03324390125; imran.amjad@riphah.edu.pk

Muhammad Asif Javed, PhD*

CONTACT

+923224209422; a.javed@riphah.edu.pk

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 5, 2026
• First Posted: May 12, 2026
• Study Start: April 5, 2026
• Primary Completion (Estimated): July 5, 2026
• Study Completion (Estimated): July 10, 2026
• Last Updated: May 12, 2026

Record last verified: 2026-05

Data Sharing

• IPD Sharing: Will not share

Locations

PA (1)