Effect of Vitamin D Supplementation on Brain Waves in Female Major Depressive Disorder Patients With Hypovitaminosis D

NCT07579078 | Enrolling By Invitation

• 1 other identifier: BMU/2026/2035
• Study Type: interventional
• Target: 34
• Locations: 1 country
• Sites: 1

Brief Summary

Major Depressive Disorder (MDD) is a common mood disorder characterized by persistent sadness, loss of interest and cognitive impairment. Emerging evidence suggests that vitamin D may exert neuroprotective and mood-regulating effects by influencing serotonin synthesis, modulating inflammation and supporting neuronal function. Vitamin D deficiency is frequently observed in MDD patients and has been linked to greater symptom severity and poorer treatment outcomes. Quantitative electroencephalography (QEEG) is a non-invasive tool for assessing brain electrical activity. Alterations in QEEG pattern such as increased theta and reduced alpha power have been reported in patients with MDD , reflecting disrupted cortical processing and emotional regulation. Although interest in the role of vitamin D in mental health is increasing, the direct effect of vitamin D supplementation on QEEG parameters in MDD patients with hypovitaminosis D is not well explored. This study aims to evaluate whether vitamin D supplementation can modulate brain wave activity in female patients with MDD and hypovitaminosis D. Therefore providing insight into its neurophysiological and therapeutic significance.

Conditions

Major Depressive Disorder (MDD); Hypovitaminosis D

Keywords

MDD; Vitamin D; QEEG; brain wave

Outcome Measures

Primary Outcomes (1)

• vitamin D

  changes in vitamin D level

  8 weeks

Secondary Outcomes (1)

• Brain wave

  8 weeks

Study Arms (2)

pre vitamin D group

EXPERIMENTAL

Pre vitamin D group will be administered vitamin D 50000IU per week for 8 weeks

Dietary Supplement: Dietary vitamin D

Post vitamin D group

OTHER

QEEG will be performed on Post vitamin D group

Dietary Supplement: Dietary vitamin D

Interventions

Dietary vitamin D DIETARY_SUPPLEMENT

No added oral vit D supplimentation

Post vitamin D group; pre vitamin D group

Eligibility Criteria

• Age: 20 Years - 40 Years
• Sex: female
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Diagnosed case of MDD by a psychiatrist form the Department of Psychiatry OPD, based on the Diagnostic and Statistical Manual of Mental Disorder, 5th edition (DSM-V) criteria set by the American Psychiatric Association.
• Hypovitaminosis D ( serum 25 ( OH )D \<30 ng/ml )
• Age range : 20-40 years
• Sex: female
• Patients must be on a stable dose regimen, without any changes in drug type or dosage, for at least 6 months prior to enrollment , to minimize confounding effects on EEG outcomes.
• Not receiving any medication that affect central nervous system other than anti-depressant drugs

You may not qualify if:

• Active smokers
• Known hypersensitivity to vitamin D
• Presence of any other serious psychiatric or systemic illness
• Pregnant women
• Lactating women
• Women taking hormonal contraceptives.
• Individuals already taking vitamin D supplements
• Patients with hypercalcemia

Sponsors & Collaborators

• Bangladesh Medical University: lead

Study Sites (1)

Bangladesh Medical University

Dhaka, Bangladesh

Location

MeSH Terms

Conditions

Depressive Disorder, Major; Vitamin D Deficiency

Condition Hierarchy (Ancestors)

Depressive Disorder; Mood Disorders; Mental Disorders; Avitaminosis; Deficiency Diseases; Malnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases

Study Officials

• Dr.Shamima Sultana, MBBS, MD

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: SINGLE
• Who Masked: INVESTIGATOR
• Masking Details: Single
• Purpose: SUPPORTIVE CARE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Resident

Study Record Dates

• First Submitted: April 30, 2026
• First Posted: May 11, 2026
• Study Start: April 25, 2026
• Primary Completion (Estimated): December 1, 2026
• Study Completion (Estimated): December 1, 2026
• Last Updated: May 12, 2026

Record last verified: 2026-05

Locations

BA (1)