Anxiety Levels in Living Liver Donors

NCT07576920 | Recruiting

• 1 other identifier: Anxiety
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

Anxiety is a state of worry and apprehension caused by internal and external threats. High preoperative anxiety levels have been associated with increased anesthetic requirements, higher morbidity, and mortality rates. In adult patients undergoing various surgical procedures, preoperative anxiety rates have been reported to range from 11% to 80%. Most studies show that postoperative anxiety levels are related to preoperative anxiety levels. In patients undergoing general anesthesia, anxiety levels increase a few days after surgery as issues related to recovery and pain become apparent. Patients with high postoperative anxiety levels have also been reported to have a higher rate of medical complications.

Conditions

Anxiety Postoperative

Keywords

Anxiety; Liver Transplantation

Outcome Measures

Primary Outcomes (1)

• Anxiety Scores

  The STAI test is a questionnaire comprising two, 20-item scales used to measure state and trait anxiety. The anxiety levels of LLDs will be evaluated by using the STAI. The STAI-State (STAI-S) form will be use to measure the current anxiety level. The test includes questions about how the person feels at that moment. Answers are given on a scale of 4 points. For example: I am calm right now: not at all=1, a little=2, a lot=3, completely=4. The STAI-Trait (STAI-T) form will be use to measure the underlying (ongoing/personality) anxiety level of the patient. The test includes questions about how the person feels in general and is also answered on a scale of 4 points. Each patient will complete these forms preoperatively and postoperatively. The mean (total) score on the STAI has a minimum of 20 and a maximum of 80. The STAI scores are generally classified as no anxiety or low anxiety (score of 20-37), moderate anxiety (score of 38-44), and high anxiety (score of 45-80).

  From 24 hours prior to the operation to postoperative 3. day and 7. day

Secondary Outcomes (2)

• Presence of an alternative donor

  Prior to the operation

• Recipient Prognosis

  at the postoperative 3. day and 7. day

Study Arms (1)

Living liver donors

Liver transplant donors who will undergo surgery between May and July 2026

Behavioral: Anxiety scores

Interventions

Anxiety scores BEHAVIORAL

Anxiety scores will evaluated STAI test. The STAI test consists of two sections of 20 questions each. The first section of the test includes questions about how the person feels at that moment. Answers are given on a scale of 4 points. For example: I am calm right now: not at all=1, a little=2, a lot=3, completely=4. The second section of the test includes questions about how the person feels in general and is also answered on a scale of 4 points.

Living liver donors

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Living liver donors

You may qualify if:

• ASA 1-2 group patients aged 18-65 years who are liver transplant donors

You may not qualify if:

• Patients with communication problems, those who are illiterate,
• Patients do not have sufficient time for the tests,
• Patients using sedatives, antidepressants, or antiepileptic drugs,
• Patients with cerebrovascular or psychiatric diseases,
• Patients with alcohol or substance addiction,
• Patients who do not want or cannot undergo the second test

Sponsors & Collaborators

• Inonu University: lead

Study Sites (1)

Turgut Ozal Medical Center

Malatya, 44315, Turkey (Türkiye)

RECRUITING

Related Publications (1)

• Erdogan MA, Ucar M, Ozgul U, Erdogan S, Colak YZ, Ozhan O, Yaman R, Ugur Y, Aydemir S, Parlakpinar H. Preoperative and Postoperative Endogenous Melatonin and Anxiety Levels and Their Correlation in Living Liver Donors. Exp Clin Transplant. 2025 Apr;23(4):278-284. doi: 10.6002/ect.2021.0060. Epub 2021 Jul 16.

  PMID: 34269646 BACKGROUND

MeSH Terms

Conditions

Anxiety Disorders

Condition Hierarchy (Ancestors)

Mental Disorders

Study Officials

• Zekine Begeç, professor

  Inonu University Department of Anesthesia

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Zekine Begeç, Professor

CONTACT

904223410660; zekine.begec@inonu.edu.tr

Muharrem Uçar, Professor

CONTACT

904223410660; umuharrem@hotmail.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Prof.

Study Record Dates

• First Submitted: April 29, 2026
• First Posted: May 8, 2026
• Study Start: May 4, 2026
• Primary Completion: July 15, 2026
• Study Completion: July 30, 2026
• Last Updated: June 16, 2026

Record last verified: 2026-06

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)