Multilevel Intervention for LDCT Lung Cancer Screening and Smoking Cessation Among African Americans

NCT07576595 | Recruiting

• 2 other identifiers: 77501R01MD019690-01
• Study Type: interventional
• Target: 250
• Locations: 1 country
• Sites: 2

Brief Summary

This study aims to reduce disparities and the burden of lung cancer among African American smokers by supporting a Multiple-level intervention integrating lung cancer screening and smoking cessation (MILS), followed the NIH DEIA strategies using multilevel interventions that impact determinants of health and address health disparities at appropriate time points across the life course.

Conditions

Disparities; African American; Tobacco Use Cessation; Prevention; Intervention Study; Adults Aged 50 Years and Older; Lung Cancer Screening

Outcome Measures

Primary Outcomes (5)

• Stage of Change for Smoking Cessation

  Stage of change in smoking cessation behavior

  Baseline, immediately post-intervention, and 6-month follow-up

• 7-Day Point Prevalence Abstinence Rate

  Proportion of participants reporting no smoking in the past 7 days

  Baseline, immediately post-intervention, and 6-month follow-up

• 24-Hour Point Prevalence Abstinence Rate

  Proportion of participants reporting no smoking in the past 24 hours

  Baseline, immediately post-intervention, and 6-month follow-up

• Daily Cigarette Consumption

  Number of cigarettes smoked per day

  Baseline, immediately post-intervention, and 6-month follow-up

• Nicotine Dependence (Fagerström Test for Nicotine Dependence)

  Nicotine dependence measured using the Fagerström Test for Nicotine Dependence (FTND), range 0-10, higher scores indicate greater dependence

  Baseline, immediately post-intervention, and 6-month follow-up

Secondary Outcomes (2)

• Lung Cancer Screening (LDCT) Uptake

  Baseline, immediately post-intervention, 6 months

• Intent to Undergo Lung Cancer Screening

  Baseline, immediately post-intervention, 6 months

Study Arms (2)

Control

NO INTERVENTION

No intervention

Screening

EXPERIMENTAL

LDCT lung cancer screening

Behavioral: Smoking cessation multilevel Intervention

Interventions

Smoking cessation multilevel Intervention BEHAVIORAL

The intervention will utilize a multilevel intervention based on the Social Ecological Model's individual, institutional, and community levels.

Screening

Eligibility Criteria

• Age: 50 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• African American
• + pack years of smoking
• eligible for or received LDCT screening
• current smoker
• English speaking

You may not qualify if:

• N/A

Sponsors & Collaborators

• Louisiana State University Health Sciences Center in New Orleans: lead
• National Institute on Minority Health and Health Disparities (NIMHD): collaborator

Study Sites (2)

LSUHSC School of Public Health

New Orleans, Louisiana, 70112, United States

RECRUITING

University Medical Center

New Orleans, Louisiana, 70112, United States

RECRUITING

Related Publications (1)

• Ahmad, A., & Singh, J. (2022). Influence of Processes of Change on Stages of Change for Smoking Cessation. Journal of Applied Social Science, 16(1), 209-222. https://doi.org/10.1177/19367244211036994 Andritsou, M., Schoretsaniti, S., Litsiou, E., Saltagianni, V., Konstadara, K., Spiliotopoulou, A., Zakynthinos, S., & Katsaounou, P. (2016). Success rates are correlated mainly to completion of a smoking cessation program. European Respiratory Journal, 48. https://doi.org/10.1183/13993003.congress-2016.PA4599 Baker, T. B., Burris, J. L., & Fiore, M. C. (2022). Helping African American individuals quit smoking: Finally, some progress. JAMA, 327(22), 2192-2194. Baker, T. B., Mermelstein, R., Collins, L. M., Piper, M. E., Jorenby, D. E., Smith, S. S., Christiansen, B. A., Schlam, T. R., Cook, J. W., & Fiore, M. C. (2011). New methods for tobacco dependence treatment research. Annals of Behavioral Medicine, 41(2), pp.192-207. https://doi.org/10.1007/s12160-010-9252-y Collins, L. M., Baker, T. B., Mermelstein, R. J., Piper, M. E., Jorenby, D. E., Smith, S. S., ... & Fiore, M. C. (2011). The multiphase optimization strategy for engineering effective tobacco use interventions. Annals of Behavioral Medicine, 41(2), pp.208-226. Cornelius, M. E., Loretan, C. G., Jamal, A., Lynn, B. C. D., Mayer, M., Alcantara, I. C., & Neff, L. (2023). Tobacco Product Use Among Adults-United States, 2021. Morbidity and Mortality Weekly Report, 72(18), pg.475. Etter, J. F., Vu Duc, T., & Perneger, T. V. (1999). Validity of the Fagerström test for nicotine dependence and of the Heaviness of Smoking Index among relatively light smokers. Addiction (Abingdon, England), 94(2), 269-281. https://doi.org/10.1046/J.1360-0443.1999.94226910.X Fedewa, S. A., Kazerooni, E. A., Studts, J. L., Smith, R. A., Bandi, P., Sauer, A. G., ... & Silvestri, G. A. (2021). State variation in low-dose computed tomography scanning for lung cancer screening in the United States. Journal of the National Cancer Institute, 113(

  BACKGROUND

MeSH Terms

Conditions

Tobacco Use Cessation

Condition Hierarchy (Ancestors)

Health Behavior; Behavior

Study Officials

• Tung Sung Tseng, DrPH, MS

  LSUHSC New Orleans

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Jessica Kassner, MS, MPH

CONTACT

504-568-5724; jkassn@lsuhsc.edu

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: SEQUENTIAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Model Details: Group 1 will receive multiple levels intervention integrating lung cancer screening and smoking cessation (MILS). Group 2 will be a control group and receive treatment at a later date.

Study Record Dates

• First Submitted: April 24, 2026
• First Posted: May 8, 2026
• Study Start: April 17, 2025
• Primary Completion (Estimated): June 1, 2029
• Study Completion (Estimated): June 1, 2030
• Last Updated: May 8, 2026

Record last verified: 2026-04

Data Sharing

• IPD Sharing: Will share

Locations

US (2)