Multilevel Interventions to Increase Adherence to Lung Cancer Screening

NCT05747443 | Active Not Recruiting

• 1 other identifier: 220-115.001
• Study Type: interventional
• Target: 1,837
• Locations: 1 country
• Sites: 1

Brief Summary

Screening for lung cancer has the potential for a profound public health benefit. Repeat annual screening is necessary for early detection of lung cancer. The investigators will test two interventions which include patient education and reminders to improve adherence to lung cancer screening.

Conditions

Lung Cancer; Lung Cancer Screening

Keywords

Lung Cancer; Low dose CT (LDCT); Lung Cancer Screening; Stepped Reminders; Educational Video; User centered design; Stakeholders; Evaluation; Qualitative; Patient Partners; Adherence

Outcome Measures

Primary Outcomes (1)

• Rate of repeat annual lung cancer screening

  Electronic health records will be searched for screening low dose CT (LDCT).

  9-15 months after index LDCT

Secondary Outcomes (2)

• Knowledge of lung cancer screening

  8 weeks after index LDCT

• Attitudes and beliefs

  8 weeks after index LDCT

Study Arms (4)

Patient Video only

EXPERIMENTAL

About 3 weeks after the index LDCT, the study Medical Assistant (MA) will deliver a link to the Patient Voices Video, an educational video about lung cancer screening.

Other: Patient Education

Stepped Reminders only

EXPERIMENTAL

Prior to patient's next LDCT scan is due, MA begins Stepped Reminders intervention: MA pends LDCT orders to PCP to sign. MA sends reminders to patient when order is placed and follows up by phone if patient has not scheduled LDCT.

Other: Stepped Reminders

Patient Video and Stepped Reminders

EXPERIMENTAL

See above. Those assigned to the Patient Video and Stepped Reminders will receive both interventions, as described above.

Other: Stepped Reminders; Other: Patient Education

Usual Care

NO INTERVENTION

Those assigned to the the Usual Care arm will continue to receive usual lung cancer screening care.

Interventions

Stepped Reminders OTHER

Stepped Reminders, which directly reminds providers to order the next LDCT scan and then reminds patients they are due and prompts them to schedule LDCT with Radiology.

Patient Video and Stepped Reminders; Stepped Reminders only

Patient Education OTHER

The Patient Voices Video is an educational video about lung cancer screening.

Patient Video and Stepped Reminders; Patient Video only

Eligibility Criteria

• Age: 50 Years - 78 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• KPWA members
• Aged 50-78 years
• Have a negative screening LDCT scan
• Speak English or Spanish
• Meet US Preventive Services Task Force guidelines

You may not qualify if:

• Patients who were previously diagnosed with lung cancer,
• Patients who have a positive scan,
• Patients who have an indicator for interpreter services, except for Spanish

Sponsors & Collaborators

• Kaiser Permanente: lead
• Fred Hutchinson Cancer Center: collaborator
• Hackensack Meridian Health: collaborator

Study Sites (1)

Kaiser Permanente

Seattle, Washington, 98101, United States

Location

Related Publications (3)

• Vasavada A, Palazzo L, Luce C, Sanchez M, Triplette M, Ralston JD, Carter-Bawa L, Green BB, Gao H, Li CI, Anderson ML, Su YR, Rogers K, Wernli KJ. "It's coming whether we want it to or not": A qualitative exploration of older adults' comfort with and perceptions of technology and digital health. Res Sq [Preprint]. 2025 Nov 19:rs.3.rs-8001649. doi: 10.21203/rs.3.rs-8001649/v1.

  PMID: 41333381 DERIVED

• Wernli KJ, Anderson ML, Palazzo L, Luce C, Bezman N, Chin M, Gao H, Ralston JD, Rogers K, Su YR, Triplette M, Carter-Bawa L, Vasavada A, Jordan M, West M, Boler S, Green BB. Effectiveness of Health Communication Intervention to Improve Knowledge on Timeliness to Return for Annual Lung Cancer Screening: The Larch Trial. Chest. 2026 Feb;169(2):550-561. doi: 10.1016/j.chest.2025.07.4111. Epub 2025 Sep 10.

  PMID: 40939933 DERIVED

• Luce C, Palazzo L, Anderson ML, Carter-Bawa L, Gao H, Green BB, Ralston JD, Rogers K, Su YR, Tuzzio L, Triplette M, Wernli KJ. A pragmatic randomized clinical trial of multilevel interventions to improve adherence to lung cancer screening (The Larch Study): Study protocol. Contemp Clin Trials. 2024 May;140:107495. doi: 10.1016/j.cct.2024.107495. Epub 2024 Mar 11.

  PMID: 38467273 DERIVED

MeSH Terms

Conditions

Lung Neoplasms

Interventions

Patient Education as Topic

Condition Hierarchy (Ancestors)

Respiratory Tract Neoplasms; Thoracic Neoplasms; Neoplasms by Site; Neoplasms; Lung Diseases; Respiratory Tract Diseases

Intervention Hierarchy (Ancestors)

Health Education; Preventive Health Services; Health Services; Health Care Facilities Workforce and Services

Study Officials

• Karen Wernli, PhD

  Kaiser Permanente

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: HEALTH SERVICES RESEARCH
• Intervention Model: FACTORIAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 17, 2023
• First Posted: February 28, 2023
• Study Start: December 12, 2022
• Primary Completion: July 5, 2025
• Study Completion (Estimated): June 30, 2026
• Last Updated: December 24, 2025

Record last verified: 2025-12

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)