Impact of Microbiome in Endometriosis Development

NCT07576361 | Completed

• 1 other identifier: PAP_RI2_2019/04
• Study Type: observational
• Target: 48
• Locations: 1 country
• Sites: 1

Brief Summary

Endometriosis is a chronic disease, of which the pathophysiology is still unknown. Several theories exist, the one of menstrual blood flow has been retained until now but does not fully explain it. The main symptoms are dysmenorrhea, dyspareunia and infertility. The aim of this study is to evaluate the impact of c.albicans colonization of vaginal microbioma in development of endometriosis

Conditions

Endometriosis

Keywords

C.Albicans; dysbiosis; endometriosis; inflammation

Outcome Measures

Primary Outcomes (1)

• vaginal dysbiosis with C. albicans

  comparison of percentages between the two groups

  At inclusion

Secondary Outcomes (4)

• correlation between vaginal dysbioses and the presence of Candida hyphae

  At inclusion

• impact of endometriosis on HPVhr carrying

  At inclusion

• inflammatory biological markers involved in the endometriotic process

  At inclusion

• inflammatory biological markers involved in the endometriotic process

  At inclusion

Study Arms (2)

case

Patient with confirmed or highly suspected endometriosis

Control

No confirmed or highly suspected endometriosis

Eligibility Criteria

• Age: 18 Years - 50 Years
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Probability Sample

Study Population

women aged 18-50 years old

You may qualify if:

• For cases :
• aged 18-50 years old With confirmed or highly suspected endometriosis Affiliated to a social security system For controls: -aged 18-50 years old No confirmed or highly suspected Affiliated to a social security system

You may not qualify if:

• Minors; Pregnant women; Protected persons, or persons placed under the protection of justice; Refusal to participate

Sponsors & Collaborators

• Centre Hospitalier Universitaire de la Guadeloupe: lead

Study Sites (1)

Centre Hospitalier Universitaire de la Guadeloupe

Les Abymes, Guadeloupe, 97159, Guadeloupe

Location

Biospecimen

Retention: SAMPLES WITHOUT DNA

vaginal samples, buccal samples

MeSH Terms

Conditions

Endometriosis; Dysbiosis; Inflammation

Condition Hierarchy (Ancestors)

Genital Diseases, Female; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Genital Diseases; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• GÜLEN AYHAN, Doctor

  CHU de la Guadeloupe

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 4, 2026
• First Posted: May 8, 2026
• Study Start: November 25, 2020
• Primary Completion: November 17, 2021
• Study Completion: November 17, 2021
• Last Updated: May 8, 2026

Record last verified: 2026-05

Data Sharing

• IPD Sharing: Will not share

Locations

GU (1)