A Retrospective Study on Clinical Characteristics and Outcomes of Patients With Pneumonia

NCT07574866 | Not Yet Recruiting

• 1 other identifier: P-2026-003
• Study Type: observational
• Target: 500
• Locations: 1 country
• Sites: 1

Brief Summary

Retrospective Analysis of Clinical Characteristics and Prognostic Factors in Hospitalized Pneumonia Patients from April 2023 to April 2026. Background: Pneumonia remains the leading cause of death from infectious diseases in adults worldwide, with an increasingly severe disease burden exacerbated by population aging and the frequent emergence of drug-resistant bacteria; in China, severe pneumonia accounts for a striking 13.58% to 20.05% of hospitalized cases. In recent years, shifts in the pathogen spectrum (e.g., COVID-19, influenza A) and patient demographic characteristics have posed new challenges for clinical management. However, existing studies mostly focus on single pathogens or specific populations (e.g., ICU patients), lacking systematic analyses of the full-disease course characteristics of general hospitalized pneumonia patients. Furthermore, in the post-pandemic era, the clinical phenotypes, treatment responses, and prognostic factors of pneumonia may have evolved, necessitating evidence-based support from real-world data. This study aims to conduct a retrospective analysis to clarify the epidemiological characteristics, etiological distribution, and prognostic factors influencing current hospitalized pneumonia patients, thereby providing a basis for optimizing diagnosis and treatment strategies.

Conditions

Pneumonia

Keywords

pneumonia

Outcome Measures

Primary Outcomes (1)

• 28-day all-cause mortality rate

  28 days after admission

Secondary Outcomes (8)

• Demographic characteristics

  28 days after admission

• Comorbidities

  28 days after admission

• Symptomatic manifestations

  28 days after admission

• Laboratory tests

  28 days after admission

• Imaging Examination

  28 days after admission

Other Outcomes (2)

• Utilization of Antimicrobial Agents

  28 days after admission

• Clinical Outcomes (cured, improved, deceased)

  28 days after admission

Study Arms (1)

pneumonia

pneumonia

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

From April 2023 to April 2026, all adult patients who were hospitalized due to pneumonia and met the diagnostic criteria

You may qualify if:

• Age ≥ 18 years old;
• Meet the diagnostic criteria for pneumonia (acute onset + new infiltrates on imaging);
• Have a positive result from pathogen testing;
• Time from onset to admission ≤ 72 hours (to ensure being in the acute phase of the disease);
• Sign a written informed consent form.
• A diagnosis of "severe pneumonia" can be made if one of the main criteria or ≥ 3 of the secondary criteria are met.
• Main criteria:
• ① Tracheal intubation requiring mechanical ventilation
• ② Need for vasoactive drugs after active fluid resuscitation for septic shock
• Secondary criteria:
• Respiratory rate ≥ 30 breaths/min
• PaO₂/FiO₂ ≤ 250 mm Hg
• Multiple lobe infiltrates
• Confusion and/or disorientation ⑤ Blood urea nitrogen ≥ 20 mg/dL
• ⑥ Leukopenia (WBC \< 4×10⁹/L)

You may not qualify if:

• \) Patients with severely lacking medical records;
• \) Those whose main manifestations are other non-infectious diseases (such as pulmonary edema, lung cancer, pulmonary embolism, etc.); 3) Those whose main diagnosis is active pulmonary tuberculosis, non-infectious interstitial lung disease, etc.; 4) Patients considered not applicable by the researchers.

Sponsors & Collaborators

• Zhonghao Fang: lead
• Fifth Affiliated Hospital of Guangzhou Medical University: collaborator

Study Sites (1)

Fifth Affiliated Hospital of Guangzhou Medical University

Guangzhou, China

Location

MeSH Terms

Conditions

Pneumonia

Condition Hierarchy (Ancestors)

Respiratory Tract Infections; Infections; Lung Diseases; Respiratory Tract Diseases

Study Officials

• Zifeng Yang

  The First Affiliated Hospital of Guangzhou Medical University

  STUDY DIRECTOR

Central Study Contacts

Liang Peng, Doctor

CONTACT

86-020-85959142; pl_206@126.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Doctor

Study Record Dates

• First Submitted: April 28, 2026
• First Posted: May 8, 2026
• Study Start: April 1, 2026
• Primary Completion (Estimated): October 1, 2026
• Study Completion (Estimated): December 1, 2026
• Last Updated: May 8, 2026

Record last verified: 2026-04

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)