Candida Albicans in Syrian Patients With Periodontitis

NCT07574827 | Recruiting DMC

• 1 other identifier: 06-05-2025
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

Periodontitis is a significant oral health issue characterized by inflammation and destruction of the supporting structures of the teeth. Recent research has indicated that Candida albicans, a common fungal pathogen, may play a role in the exacerbation of periodontal diseases. This study aims to investigate the prevalence and impact of Candida albicans in Syrian patients diagnosed with periodontitis, contributing to a better understanding of its role in oral health within this population.

Conditions

Periodontal Disease; Periodontal Diseases; Periodontitis

Keywords

Candida Albicans; Candida; Periodontitis; Sabouraud Dextrose Agar; Culture

Outcome Measures

Primary Outcomes (1)

• Detection of Candida Species in Subgingival Samples

  At enrollment

Secondary Outcomes (1)

• Periodontal Screening and Recording Index

  At enrollment

Study Arms (2)

Syrian Patients With Periodontitis

Diagnostic Test: Periodontal Assessment and Sample Collection from Subgingival Pockets

Syrian Individuals without Periodontal Disease

Diagnostic Test: Periodontal Assessment and Sample Collection from Subgingival Pockets

Interventions

Periodontal Assessment and Sample Collection from Subgingival Pockets DIAGNOSTIC_TEST

Clinical examination to assess periodontal status. Collection of subgingival plaque samples for microbiological analysis to identify Candida Albicans.

Syrian Individuals without Periodontal Disease; Syrian Patients With Periodontitis

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Syrian patients with periodontitis at Al-Hawash Private University Dental Clinics

You may qualify if:

• Patients aged 18 years and older.
• Diagnosed with chronic periodontitis based on clinical examination (attachment loss, probing depth).
• Consent to participate in the study.

You may not qualify if:

• Patients with systemic diseases affecting oral health (e.g., diabetes, immunosuppressive conditions).
• Recent antibiotic or antifungal treatment within the last three months.

Sponsors & Collaborators

• Al-Hawash Private University: lead

Study Sites (1)

Al-Hawash Private University, Faculty of Dentistry

Homs, Syria

RECRUITING

MeSH Terms

Conditions

Periodontal Diseases; Periodontitis; Torulopsis

Condition Hierarchy (Ancestors)

Mouth Diseases; Stomatognathic Diseases

Study Officials

• Ali Abou Sulaiman, Ph.D. in Periodontology

  Al-Hawash Private University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Ali Abou Sulaiman

CONTACT

+963956790836; dr.ali.abousulaiman@hpu.edu.sy

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 22, 2026
• First Posted: May 8, 2026
• Study Start: April 7, 2026
• Primary Completion (Estimated): August 1, 2026
• Study Completion (Estimated): September 1, 2026
• Last Updated: May 8, 2026

Record last verified: 2025-08

Locations

SY (1)