Detection of Microplastics in Patients With Periodontitis

NCT07231198 | Not Yet Recruiting

• 2 other identifiers: 17538733SFU
• Study Type: observational
• Target: 25
• Locations: 0 countries
• Sites: N/A

Brief Summary

Plastic particles known as microplastics are now a ubiquitous part of the environment. Human exposure to microplastics occurs through the consumption of contaminated food and polluted air, which affect the intestinal system. Several studies have detected the presence of microplastics in various parts of the human digestive system, e.g., in feces. Unfortunately, little is known about the presence of microplastics in the mouth as the primary part of the digestive system. Periodontal pockets can be considered an ideal deposition site for microplastics. Since microplastics are suspected of being an immunomodulatory factor, there is great interest in their presence in subgingival plaque and their possible exacerbation of chronic inflammatory diseases such as periodontitis. The following study aims to clarify the presence, classification, and concentration of microplastics in subgingival plaque. No comparable study has been identified to date.

Conditions

Periodontal Diseases; Periodontitis

Keywords

periodontitis; microplastics

Outcome Measures

Primary Outcomes (1)

• Microplastics

  number of patients with periodontitis with microplastics in periodontal pockets, quantification of microplastic particles in periodontal pockets, qualitative analysis of microplastic

  one year

Study Arms (1)

patients with periodontitis, stage 3 or 4

Status assessment with supragingival cleaning Sample collection with sterile universal curette (steel) from the bottom of the pockets of the 4 deepest gum pockets (ST \>= 5mm) pooled in ultrapure water

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients with periodontitis, stage 3 or 4, with a full mouth probing score at the Department of Periodontology, Dental Clinics, Sigmund Freud University, Vienna, Austria

You may qualify if:

• Adults aged 18 and over
• Gender: Female / male / diverse
• Patients
• who have been diagnosed with stage III and IV periodontitis.
• who have not yet started periodontal treatment.
• who still have at least 20 teeth. Providing written consent to participate in the study.

You may not qualify if:

• Patients
• who have already been treated for periodontitis
• who have already undergone/begun periodontitis treatment

Sponsors & Collaborators

• Sigmund Freud PrivatUniversitat: lead

Related Publications (1)

• Ogata Y. Diffusion of the magnetization profile in the XX model. Phys Rev E Stat Nonlin Soft Matter Phys. 2002 Dec;66(6 Pt 2):066123. doi: 10.1103/PhysRevE.66.066123. Epub 2002 Dec 18.

  PMID: 12513363 BACKGROUND

MeSH Terms

Conditions

Periodontal Diseases; Periodontitis

Condition Hierarchy (Ancestors)

Mouth Diseases; Stomatognathic Diseases

Central Study Contacts

Hady Haririan, Univ.-Prof., Dr., PhD, MSc

CONTACT

+4317201966; hady.haririan@med.sfu.ac.at

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Target Duration: 1 Day
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Prof.

Study Record Dates

• First Submitted: November 13, 2025
• First Posted: November 17, 2025
• Study Start: February 1, 2026
• Primary Completion (Estimated): February 1, 2027
• Study Completion (Estimated): February 1, 2028
• Last Updated: November 19, 2025

Record last verified: 2025-11

Data Sharing

• IPD Sharing: Will share