NCT07574112

Brief Summary

This randomized controlled trial compared the effects of Muscle Energy Technique (MET) with and without Myofascial Release (MFR) in patients with cervicogenic headache. Forty participants aged 20-40 years were randomly assigned into two groups: MET only and MET combined with MFR. The intervention was delivered over five sessions across two weeks. Outcomes included pain intensity (VAS), cervical range of motion, and disability (Neck Disability Index), assessed at baseline and post-intervention. The study evaluated which intervention produced greater improvements in pain, function, and cervical mobility.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
40

participants targeted

Target at P25-P50 for not_applicable

Timeline
Completed

Started Feb 2025

Shorter than P25 for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

February 25, 2025

Completed
9 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

November 25, 2025

Completed
20 days until next milestone

Study Completion

Last participant's last visit for all outcomes

December 15, 2025

Completed
5 months until next milestone

First Submitted

Initial submission to the registry

May 1, 2026

Completed
6 days until next milestone

First Posted

Study publicly available on registry

May 7, 2026

Completed
Last Updated

May 7, 2026

Status Verified

May 1, 2026

Enrollment Period

9 months

First QC Date

May 1, 2026

Last Update Submit

May 1, 2026

Conditions

Outcome Measures

Primary Outcomes (1)

  • Pain Intensity (VAS)

    Visual Analogue Scale (0-10) for pain intensity assessment

    Baseline and 2 weeks post-intervention

Secondary Outcomes (2)

  • Cervical Range of Motion

    Baseline and 2 weeks post-intervention

  • Neck Disability Index (NDI)

    Baseline and 2 weeks post-intervention

Study Arms (2)

Muscle Energy Technique (MET)

ACTIVE COMPARATOR

Participants in this group received Muscle Energy Technique (MET) alone. The intervention was applied over five treatment sessions within two weeks. This group served as the comparison group to evaluate the effects of MET without Myofascial Release.

Procedure: Muscle Energy Technique (MET)

Muscle Energy Technique (MET) + Myofascial Release (MFR)

EXPERIMENTAL

Participants in this group received a combination of Muscle Energy Technique (MET) and Myofascial Release (MFR). The intervention was delivered over five treatment sessions within two weeks to evaluate its combined effect on pain, cervical range of motion, and disability.

Procedure: Muscle Energy Technique (MET)Procedure: Myofascial Release (MFR)

Interventions

Muscle Energy Technique (MET) was applied to the cervical region muscles using isometric contractions followed by passive stretching. The technique was performed in a controlled manner to improve muscle flexibility, reduce pain, and enhance cervical mobility over five treatment sessions within two weeks.

Also known as: Muscle Energy Technique
Muscle Energy Technique (MET)Muscle Energy Technique (MET) + Myofascial Release (MFR)

Sustained manual pressure applied to cervical and upper trapezius muscles to release fascial restrictions.

Muscle Energy Technique (MET) + Myofascial Release (MFR)

Eligibility Criteria

Age20 Years - 40 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64)

You may qualify if:

  • years old adults with cervicogenic headache (CGH) based on the International Classification of Headache Disorders (ICHD) Trapezius muscle tightness and tenderness (on palpation) The visual analog score (VAS) of pain should be 2 or more CGH symptoms are accompanied by the measurable restriction of cervical range of motion (ROM)

You may not qualify if:

  • Prior headache history of migraine or non-cervicogenic Past cervical surgery in less than 6 months or significant cervical injury Nervous system problems like radiculopathy, myelopathy or other central nervous system pathology

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

University of Lahore

Lahore, Punjab Province, Pakistan

Location

Related Publications (1)

  • Samreen Z, Waseem I, Mustansar A. Muscle Energy Technique With and Without Myofascial Release in Patients with Cervicogenic Headache. Insights in Journal of Health Research. 2025. https://doi.org/10.71000/vy8k2r11

    RESULT

MeSH Terms

Conditions

Post-Traumatic Headache

Interventions

Myofascial Release Therapy

Condition Hierarchy (Ancestors)

Headache Disorders, SecondaryHeadache DisordersBrain DiseasesCentral Nervous System DiseasesNervous System Diseases

Intervention Hierarchy (Ancestors)

MassageTherapy, Soft TissueMusculoskeletal ManipulationsComplementary TherapiesTherapeuticsPhysical Therapy ModalitiesRehabilitation

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
OUTCOMES ASSESSOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Model Details: This study used a parallel-group randomized controlled design. Participants were randomly allocated into two groups: one receiving Muscle Energy Technique (MET) alone and the other receiving a combination of Muscle Energy Technique and Myofascial Release (MFR). Both interventions were delivered over a fixed treatment period, and outcomes were compared between groups after completion of the intervention.
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Principal Investigator

Study Record Dates

First Submitted

May 1, 2026

First Posted

May 7, 2026

Study Start

February 25, 2025

Primary Completion

November 25, 2025

Study Completion

December 15, 2025

Last Updated

May 7, 2026

Record last verified: 2026-05

Data Sharing

IPD Sharing
Will not share

Locations