Association Between Sarcopenia, Fatigue and Orthostatic Intolerance in Geriatric Patients: A Case Control Study

NCT07564830 | Not Yet Recruiting DMC

• 1 other identifier: FMASU MD249/2025
• Study Type: observational
• Target: 90
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to explore the relationship between sarcopenia, fatigue, and orthostatic intolerance in older adults. It will be conducted among geriatric patients attending Ain Shams University Hospitals. Participants aged 65 years and older will be divided into two groups: those with sarcopenia, diagnosed according to the European Working Group on Sarcopenia in Older People 2, and age- and sex-matched controls without sarcopenia. The study will compare levels of fatigue and the presence of orthostatic intolerance between the two groups. The findings are expected to improve understanding of how sarcopenia is associated with fatigue and orthostatic symptoms in the elderly population, which may help guide better clinical assessment and management.

Conditions

Sarcopenia; Fatigue; Orthostatic Intolerance

Keywords

geriatric; sarcopenia; orthostatic intolerance

Outcome Measures

Primary Outcomes (1)

• Fatigue severity measured by Fatigue Severity Scale (FSS)

  Difference in Fatigue Severity Scale (FSS) total score between geriatric patients with sarcopenia (defined according to European Working Group on Sarcopenia in Older People 2 criteria) and those without sarcopenia. Unit of Measure: FSS total score (range: 1-7)

  Baseline

Secondary Outcomes (4)

• Orthostatic intolerance symptoms measured by Orthostatic Hypotension Questionnaire (OHQ)

  Baseline

• Orthostatic systolic blood pressure change

  Baseline (during orthostatic assessment)

• Orthostatic diastolic blood pressure change

  Baseline (during orthostatic assessment)

• Orthostatic heart rate change

  Baseline (during orthostatic assessment)

Study Arms (2)

cases

Cases: Elderly patients (≥65 years) diagnosed with sarcopenia based on the European Working Group on Sarcopenia in Older People 2 (EWGSOP2) criteria.

controls

Controls: Age- and sex-matched elderly patients without sarcopenia.

Eligibility Criteria

• Age: 65 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

elderly patients both males and females who are interviewed at AIN SHAMS UNIVERSITY HOSPITALS or at the hospital clinic.

You may qualify if:

• Patients (males or females) aged 65 or above years old.
• Participants who are willing to participate in the study.

You may not qualify if:

• Patients who are not willing to participate in the study.
• patients with end organ damage (CHF NYHA III/IV), end-stage renal disease, Liver cell failure, respiratory failure.
• Patients with arrhythmia or using pacemakers
• patients diagnosed with parkinsonism, Diabetes mellitus, or peripheral neuropathy.
• Active infections or inflammatory conditions (e.g., sepsis, rheumatoid flare-up)
• Patient with acute stroke, Critically ill patients, Terminal illness, Bedridden or completely immobile patients,
• Medications Influencing Fatigue/OI: High-dose opioids, sedatives, or drugs causing significant orthostatic hypotension (e.g., alpha-blockers, diuretics without stable control)

Sponsors & Collaborators

• Ain Shams University: lead

Study Sites (1)

Ain shams university

Cairo, Abbasya, Egypt

Location

MeSH Terms

Conditions

Sarcopenia; Fatigue; Orthostatic Intolerance

Condition Hierarchy (Ancestors)

Muscular Atrophy; Neuromuscular Manifestations; Neurologic Manifestations; Nervous System Diseases; Atrophy; Pathological Conditions, Anatomical; Pathological Conditions, Signs and Symptoms; Signs and Symptoms; Primary Dysautonomias; Autonomic Nervous System Diseases

Study Officials

• doha rashedy ali, professor

  Ain shams university faculty of medicine.

  STUDY DIRECTOR

Central Study Contacts

rewayda walid mahgoub, M.B.B.CH., M.Sc.

CONTACT

+201144430657; g19-29512051701747@med.asu.edu.eg

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 2, 2026
• First Posted: May 4, 2026
• Study Start: May 1, 2026
• Primary Completion (Estimated): January 1, 2027
• Study Completion (Estimated): April 1, 2027
• Last Updated: May 4, 2026

Record last verified: 2026-04

Locations

EG (1)