PRP vs PRF in Management of Striae Distensae
Split-Side Comparative Clinical Study of Platelet-Rich Fibrin Versus Platelet-Rich Plasma With or Without Microneedling in Treatment of Striae Distensae
1 other identifier
interventional
30
1 country
1
Brief Summary
A split-side comparative clinical study evaluating the efficacy and safety of injectable platelet-rich fibrin (PRF) versus platelet-rich plasma (PRP), alone or combined with microneedling, in the treatment of striae distensae. Thirty patients received PRF or PRP on one side and combination therapy with microneedling on the contralateral side over five sessions. Outcomes included striae width, length, severity score, and patient satisfaction
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable
Started Feb 2024
Typical duration for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
February 2, 2024
CompletedPrimary Completion
Last participant's last visit for primary outcome
September 25, 2025
CompletedStudy Completion
Last participant's last visit for all outcomes
February 17, 2026
CompletedFirst Submitted
Initial submission to the registry
April 25, 2026
CompletedFirst Posted
Study publicly available on registry
May 1, 2026
CompletedMay 1, 2026
April 1, 2026
1.6 years
April 25, 2026
April 25, 2026
Conditions
Outcome Measures
Primary Outcomes (2)
INA score (Change in striae severity)
baseline to 1 month after last session
Change in striae severity (INA score)
1 month after last session
Study Arms (4)
PRF
ACTIVE COMPARATORIntradermal injection of platelet-rich fibrin
PRF +Microneedling
ACTIVE COMPARATORMicroneedling followed by topical PRF application
PRP
ACTIVE COMPARATORIntradermal injection of platelet-rich plasma
PRP+microneedling
ACTIVE COMPARATORInterventions
Autologous platelet-rich fibrin prepared via single-spin centrifugation without anticoagulant and injected intradermally
Performed using a dermapen device with 1 mm needle depth, followed by topical application of PRF.
Performed using a dermapen device with 1 mm needle depth, followed by topical application of PRP.
Eligibility Criteria
You may qualify if:
- Adults ≥18 years Presence of striae distensae (rubrae or alba) Willingness to participate and provide informed consent
You may not qualify if:
- Keloid or hypertrophic scar tendency Bleeding disorders or anticoagulant use Pregnancy Active skin infections (e.g., herpes, impetigo, tinea) History of malignancy or collagen disease Use of antineoplastic drugs Conditions impairing wound healing Unrealistic expectations
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Zagazig University Hospitals
Zagazig, Zagazig--, 44519, Egypt
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- DOUBLE
- Who Masked
- PARTICIPANT, OUTCOMES ASSESSOR
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER GOV
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Dr
Study Record Dates
First Submitted
April 25, 2026
First Posted
May 1, 2026
Study Start
February 2, 2024
Primary Completion
September 25, 2025
Study Completion
February 17, 2026
Last Updated
May 1, 2026
Record last verified: 2026-04
Data Sharing
- IPD Sharing
- Will not share