Microneedling Versus Carboxytherapy in Stria Distensae Rubra

NCT07001644 | Active Not Recruiting

• 1 other identifier: 0107162
• Study Type: interventional
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this study is to evaluate and compare the efficacy and safety of microneedling and carboxytherapy either with or without platelet-rich plasma in the treatment of striae distensae rubra.

Conditions

Striae Distensae

Keywords

striae distensae; striae rubra; microneedling; carboxytherapy

Outcome Measures

Primary Outcomes (1)

• Reduction in the size of the stria distensae rubra

  will be assessed by digital photography, actual measurement of the stria before and after treatment, and objective assessment of the percent of improvement

  group I: six sessions over 18 weeks , group II: 6 sessions over 12 weeks, followed in both groups by three months of follow up

Study Arms (2)

treated with microneedling

ACTIVE COMPARATOR

microneedling with topical application of PRP on one side of abdomen and microneedling only on the other side

Device: microneedling

treated with carboxytherapy

ACTIVE COMPARATOR

carboxytherapy with intradermal injection of PRP on one side of abdomen and carboxytherapy only on the other side

Device: Carboxytherapy

Interventions

microneedling DEVICE

microneedling with topical application of PRP on one side of abdomen and microneedling only on the other side.

treated with microneedling

Carboxytherapy DEVICE

carboxytherapy with intradermal injection of PRP on one side of abdomen and carboxytherapy only on the other side.

treated with carboxytherapy

Eligibility Criteria

• Age: 18 Years - 45 Years
• Sex: female
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Female patients.
• Age ranging from 18-45 years old.
• Fitzpatrick skin type III-IV.
• Striae distensae rubra on the abdomen (bilateral and more or less symmetrical).

You may not qualify if:

• Patients taking immunosuppressants or having any disease affecting wound healing including diabetes.
• Patients receiving systemic glucocorticoids for chronic health conditions.
• Patients with chronic dermatologic diseases such as psoriasis and vitiligo.
• Pregnant and lactating females.
• Patients with a tendency for keloid formation.
• Patients with endocrine disturbance.
• Patients with autoimmune diseases, systemic diseases such as severe anemia, respiratory, cardiac, renal or liver disorder.
• Patients with bleeding and coagulation disorders.
• Patients who received any form of treatment for their SD in the past 6 months.

Sponsors & Collaborators

• Alexandria University: lead

Study Sites (1)

Alexandria Faculty of Medicine

Alexandria, Egypt

Location

MeSH Terms

Conditions

Striae Distensae

Interventions

Percutaneous Collagen Induction

Condition Hierarchy (Ancestors)

Skin Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Complementary Therapies; Therapeutics; Physical Therapy Modalities; Punctures; Rehabilitation

Study Officials

• professor doctor Amira Eid

  Alexandria University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 17, 2025
• First Posted: June 3, 2025
• Study Start: October 1, 2022
• Primary Completion: October 1, 2025
• Study Completion: December 1, 2025
• Last Updated: June 17, 2025

Record last verified: 2024-10

Locations

EG (1)