Brief Summary

The purpose of this study is to understand how different areas of the cerebellum (a part of the brain) control different functions and how they can be influenced by non-invasive brain stimulation. While researchers know that repetitive Transcranial Magnetic Stimulation (rTMS) can have positive effects on conditions like stroke and schizophrenia, they do not yet fully understand which specific stimulation settings work best or which exact parts of the cerebellum should be targeted for different symptoms. This study compares the effects of stimulation on two specific regions:

Lobule VIII: Linked to movement and motor learning.
CRUS I/II: Linked to attention, thinking (cognition), and predicting the timing of events.By comparing these areas, researchers hope to gain the information needed to develop better treatments for neurological and psychiatric disorders. This is a randomized, double-blind study involving 40 healthy volunteers. Participants will be split into two groups:
Group 1: Receives "exciting" (activity-increasing) stimulation.
Group 2: Receives "inhibiting" (activity-decreasing) stimulation. Each participant will attend three different test sessions in a random order:
rTMS targeting Lobule VIII
rTMS targeting CRUS I/II
Placebo (Sham) stimulation that looks and feels like the real thing but does not affect the brain. During each session, researchers will use brain imaging (fMRI) and computerized tasks to measure changes in brain connectivity and performance in motor and cognitive activities. There is no direct medical benefit to the participants. However, the results will help scientists create better therapies for patients with brain-related health issues The risks are considered minimal. Common side effects of rTMS include temporary mild headaches or a clicking sound during stimulation. MRI scans can sometimes cause mild discomfort or a feeling of closed-in spaces (claustrophobia). Researchers have put safety measures in place, such as hearing protection and constant medical supervision during scans, to minimize these risks.

Trial Health

Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment

participants targeted

Target at P50-P75 for not_applicable healthy

Timeline

41mo left

Started Sep 2026

Longer than P75 for not_applicable healthy

Geographic Reach

1 country

1 active site

Status

not yet recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

3.3 years study duration

First Submitted

Initial submission to the registry

April 17, 2026

Completed

14 days until next milestone

First Posted

Study publicly available on registry

May 1, 2026

Completed

4 months until next milestone

Study Start

First participant enrolled

September 1, 2026

Expected

3.3 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

January 2, 2030

Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

January 2, 2030

Last Updated

May 1, 2026

Status Verified

April 1, 2026

Enrollment Period

3.3 years

First QC Date

April 17, 2026

Last Update Submit

April 27, 2026

Conditions

Healthy Healthy Adult

Keywords

Repetitive Transcranial Magnetic Stimulation (rTMS)CerebellumLobule VIIICrus I/IIResting-state functional Magnetic Resonance Imaging (rs-fMRI)NeuromodulationNeuroplasticityExcitatory vs. Inhibitory StimulationNeurotypical

Outcome Measures

Primary Outcomes (1)

Change in Resting-State Functional Connectivity (RSFC) Measured by functional Magnetic Resonance Imaging (fMRI, expressed as Fisher's z-transformed correlation coefficients) within Cerebellar-Thalamo-Frontal and Cerebellar-Parieto-Motor Networks.
Functional imaging data will be pre-processed according to standard procedures: slice-timing correction, intra-run spatial realignement, inter-run realignement, distortion and motion artifact correction, band-pass filtering to remove physiological noise, and normalization into the MNI common space, followed by smoothing using FSL and SPM12 software.Subsequently, the signal within the networks of interest will be extracted using the "Conn" toolbox and compared using a General Linear Model (GLM). Connectivity maps will be generated from specific "seed" regions of interest (Crus I/II and lobule VIII), where each voxel value corresponds to the correlation with the seed region.
Baseline (Pre-stimulation) and 1-hour post-stimulation

Study Arms (12)

1 - Lobule VIII - Crus I/II - Sham Sequence - Excitatory

EXPERIMENTAL

Participants receive active rTMS to Lobule VIII in the first session, followed by active rTMS to Crus I/II in the second, and Sham stimulation in the third.