NCT07559344

Brief Summary

Muscle lengthening contractions lead to physiological responses such as strength loss, soreness, immune cell infiltration, and CK production, along with elevated heat shock proteins (HSPs), which protect and regenerate cells. Passive heating before or after exercise can aid in recovery by restoring strength and reducing soreness, requiring a core temperature of over 38.5°C for 20 minutes to be effective. Studies show that combined mechanical and thermal stress induces a cumulative HSP response, enhancing cellular protection. Thermal stress alone peaks at 16- 24 hours, whereas mechanical stress shows a biphasic response, with peaks at 3-6 hours and around 39 hours. Thus, combining heat with exercise could optimize HSP production, improving recovery by increasing and accelerating the HSP response. However, more research is needed to determine the best timing for thermal stress in human applications, especially in sports and therapy contexts. This study aimed to compare the effects of hot-water immersion administered before versus after muscle-lengthening exercise on muscle function and HSP70 expression in healthy young athletes.

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
96

participants targeted

Target at P50-P75 for not_applicable

Timeline
9mo left

Started Feb 2026

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress23%
Feb 2026Feb 2027

Study Start

First participant enrolled

February 16, 2026

Completed
2 months until next milestone

First Submitted

Initial submission to the registry

April 7, 2026

Completed
23 days until next milestone

First Posted

Study publicly available on registry

April 30, 2026

Completed
9 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

February 1, 2027

Expected
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

February 1, 2027

Last Updated

April 30, 2026

Status Verified

April 1, 2026

Enrollment Period

12 months

First QC Date

April 7, 2026

Last Update Submit

April 23, 2026

Conditions

Mechanical StressHeat StressHSP70Hot-water ImmersionRecoveryCumulative Response

Keywords

Recoverymechanical stressheat stressHSP70cumulative responsehot-water immersion

Outcome Measures

Primary Outcomes (1)

  • HSP 70 concentration

    HSP 70 concentration in third groups

    1 year

Secondary Outcomes (2)

  • gastro-intestinal temperature

    1 year

  • muscle temperature

    1 year

Study Arms (3)

41 pre-EIMD

EXPERIMENTAL

hot-water immersion at 41°C performed 24 hours before EIMD (pre-EIMD)

Other: ImmersionOther: NIRSOther: isokinetic dynamometerOther: pressure algometerOther: Hokanson armband

41 post-EIMD

EXPERIMENTAL

hot- water immersion at 41°C immediately after EIMD (post-EIMD)

Other: ImmersionOther: NIRSOther: isokinetic dynamometerOther: pressure algometerOther: Hokanson armband

36°C post- EIMD

SHAM COMPARATOR

sham immersion at 36°C post- EIMD

Other: ImmersionOther: NIRSOther: isokinetic dynamometerOther: pressure algometerOther: Hokanson armband

Interventions

ImmersionOTHER

Immersion lasted 40 minutes with the goal of reaching a core temperature of 38.5°C in the heat-stress groups

36°C post- EIMD41 post-EIMD41 pre-EIMD
NIRSOTHER

NIRS

36°C post- EIMD41 post-EIMD41 pre-EIMD
isokinetic dynamometerOTHER

isokinetic dynamometer

36°C post- EIMD41 post-EIMD41 pre-EIMD
pressure algometerOTHER

pressure algometer

36°C post- EIMD41 post-EIMD41 pre-EIMD
Hokanson armbandOTHER

Hokanson armband

36°C post- EIMD41 post-EIMD41 pre-EIMD

Eligibility Criteria

Age19 Years - 25 Years
Sexmale
Healthy VolunteersNo
Age GroupsAdult (18-64)

You may qualify if:

  • Sex: Healthy, athletic men practicing track and field (10 to 12 hours/week)
  • Age: 19 to 25 years old
  • Social security coverage
  • Signed informed consent

You may not qualify if:

  • Age over 26 years
  • Low level of physical activity (less than 8 hours per week)
  • Recent sprain (type 1, 2, or 3) or ligament rupture in the lower limb (within the last 8 months)
  • Exposure to an altitude of 2500m within 15 days prior to the protocol
  • Presence of arterial hypotension:
  • Systolic blood pressure below 90 mmHg
  • Diastolic blood pressure below 60 mmHg
  • A drop in systolic blood pressure greater than 20 mmHg upon moving from a lying to a standing position.
  • A drop in diastolic blood pressure greater than 10 mmHg upon moving from a lying to a standing position.
  • Presence of dizziness, lightheadedness, or blurred vision upon moving from a lying to a standing position.
  • Participant under guardianship/conservatorship or deprived of liberty.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

CHRU Amiens

Amiens, 80054, France

RECRUITING

MeSH Terms

Conditions

Heat Stress Disorders

Interventions

Immersion

Condition Hierarchy (Ancestors)

Wounds and Injuries

Intervention Hierarchy (Ancestors)

Investigative Techniques

Central Study Contacts

Yannis Hamidou, MD

CONTACT

33+3 22 66 82 48Hamidou.yannis@chu-amiens.fr

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
PARTICIPANT
Purpose
OTHER
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

April 7, 2026

First Posted

April 30, 2026

Study Start

February 16, 2026

Primary Completion (Estimated)

February 1, 2027

Study Completion (Estimated)

February 1, 2027

Last Updated

April 30, 2026

Record last verified: 2026-04

Data Sharing

IPD Sharing
Will not share

Locations

FR(1)