NCT05417542

Brief Summary

Premature neonates are able to discriminate phonemes and voice from 28wGA at a time the neuronal network establish contact between the environment and the cortical neurones. In the present monocentric study the investigators will analyse the response of the cortical network in premature aged between 28 and 40 wGA in response to auditory stimuli using High Resolution Electroencephalography and High Density Near Infrared Spectroscopy

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
200

participants targeted

Target at P75+ for not_applicable

Timeline
36mo left

Started May 2022

Longer than P75 for not_applicable

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress57%
May 2022May 2029

First Submitted

Initial submission to the registry

May 31, 2022

Completed
Same day until next milestone

Study Start

First participant enrolled

May 31, 2022

Completed
14 days until next milestone

First Posted

Study publicly available on registry

June 14, 2022

Completed
6.9 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

May 1, 2029

Expected
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

May 1, 2029

Last Updated

May 28, 2025

Status Verified

May 1, 2025

Enrollment Period

6.9 years

First QC Date

May 31, 2022

Last Update Submit

May 22, 2025

Conditions

Keywords

Time perceptionrhythmEEGfNIRSERPPremature neonatesDiscrimination

Outcome Measures

Primary Outcomes (6)

  • Variations of the response of the cortical network using High Resolution Electroencephalography before auditory stimuli between the 5 infant groups

    one day

  • Variations of the response of the cortical network using High Resolution Electroencephalography during auditory stimuli between the 5 infant groups

    one day

  • Variations of the response of the cortical network using High Resolution Electroencephalography after auditory stimuli between the 5 infant groups

    one day

  • variations of the response of the cortical network using High Density Near Infrared Spectroscopy before auditory stimuli between the 5 infant groups

    one day

  • variations of the response of the cortical network using High Density Near Infrared Spectroscopy during auditory stimuli between the 5 infant groups

    one day

  • variations of the response of the cortical network using High Density Near Infrared Spectroscopy after auditory stimuli between the 5 infant groups

    one day

Study Arms (5)

Exposition I

EXPERIMENTAL

preterm neonates between 28 and 30 wGA Exposition to music during the NICU period

Other: EEGOther: NIRS

Exposition II

EXPERIMENTAL

preterm neonates between 32 and 34 wGA Exposition to music during the NICU period

Other: EEGOther: NIRS

Control I

ACTIVE COMPARATOR

preterm neonates between 28 and 30 wGA

Other: EEGOther: NIRS

Control II

ACTIVE COMPARATOR

preterm neonates between 32 and 34 wGA

Other: EEGOther: NIRS

Control III

ACTIVE COMPARATOR

preterm neonates between 36 and 40 wGA

Other: EEGOther: NIRS

Interventions

EEGOTHER

EEG recording during prematurity or around term

Control IControl IIControl IIIExposition IExposition II
NIRSOTHER

NIRS recording during prematurity or around term

Control IControl IIControl IIIExposition IExposition II

Eligibility Criteria

Age0 Days - 18 Years
Sexall
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64)

You may qualify if:

  • Full term neonates between 28 and 40 weeks Gestational Age

You may not qualify if:

  • Neonates outside the age range

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

CHU Amiens

Amiens, 80054, France

RECRUITING

Central Study Contacts

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
OTHER
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

May 31, 2022

First Posted

June 14, 2022

Study Start

May 31, 2022

Primary Completion (Estimated)

May 1, 2029

Study Completion (Estimated)

May 1, 2029

Last Updated

May 28, 2025

Record last verified: 2025-05

Data Sharing

IPD Sharing
Will not share

Locations