Effect of Hyperoxygenated Environment on Maximal Muscle Strength

NCT07558928 | Recruiting

• 1 other identifier: 0131-23 ASF
• Study Type: interventional
• Target: 48
• Locations: 1 country
• Sites: 1

Brief Summary

comparing the effect of hyperoxygenated environment on maximal muscle strength in the Mid-thigh Pull Task

Conditions

Healthy Lifestyle

Keywords

power lifting; gym; force; imtp

Outcome Measures

Primary Outcomes (1)

• Maximal static muscle force production

  Participants will perform the isometric mid-thigh pull (IMTP) test using an analog dynamometer that will be purchased for the purpose of the study

  Baseline evaluation, IMPT test in HBOT chamber, Approximately 4 weeks after the first visit, participants will be exposed to the opposite intervention - HOE or SHAM - and will undergo the same isometric mid-thigh pull (IMTP) test in the chamber.

Study Arms (2)

Hyperoxygenation active treatment

ACTIVE COMPARATOR

The HYPEROXYGENATED ENVIRONMENT protocol will include a single exposure to hyperoxic environment. The session will last 60 minutes, of 100% oxygen inhalation by mask at 2 ATA. 15 minutes after reaching 2 ATA and breathing 100% oxygen - IMTP test - For measurement of peak-force at baseline and under the different oxygenation conditions, each participant will be given three attempts at every IMTP test. A three-minute rest will be given between attempts, with the aim of attaining optimal recovery

Device: Hyperbaric Oxygen Therapy - HBOT

Sham

SHAM COMPARATOR

The Sham protocol will include a single session of breathing 21% oxygen by mask while in the same multi-place chamber. SHAM pressure will go up to 1.2 ATA during the first five minutes of the session (to simulate the pressure sensation in the ears), and then decrease during the next 5 minutes to 1.03 ATA for 55 minutes. 15 minutes after reaching 1.03 ATA and breathing 21% oxygen - IMTP test - For measurement of peak-force at baseline and under the different oxygenation conditions, each participant will be given three attempts at every IMTP test. A three-minute rest will be given between attempts, with the aim of attaining optimal recovery

Device: Sham

Interventions

Hyperbaric Oxygen Therapy - HBOT DEVICE

The HYPEROXYGENATED ENVIRONMENT protocol will include a single exposure to hyperoxic environment. The session will last 60 minutes, of 100% oxygen inhalation by mask at 2 ATA

Hyperoxygenation active treatment

Sham DEVICE

The Sham protocol will include a single session of breathing 21% oxygen by mask while in the same multi-place chamber. SHAM pressure will go up to 1.2 ATA during the first five minutes of the session (to simulate the pressure sensation in the ears), and then decrease during the next 5 minutes to 1.03 ATA for 55 minutes

Sham

Eligibility Criteria

• Age: 18 Years - 45 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Healthy
• Ages 18-45
• Participants are physically active and have a recent resistance-training experience of at least six months, ≥ 3 times a week
• Participant willing and able to read, understand and sign an informed consent

You may not qualify if:

• Inability to attend scheduled clinic visits or comply with the study protocol
• Active malignancy
• Active smokers
• Previous treatment of hyperbaric chamber for any reason prior to study enrollment.
• Chest pathology incompatible with pressure changes
• Major orthopedic injury at the past 3 months
• Inner ear disease
• Lung pathology
• Claustrophobia
• Previous neurologic conditions (e.g., epilepsy, brain tumors or s/p neurosurgery etc.)
• Comorbidities and medications that rule out the subject

Sponsors & Collaborators

• Assaf-Harofeh Medical Center: lead

Study Sites (1)

The Sagol Center for Hyperbaric Medicine and Research Shamir Medical Center

Zrifin, Israel

RECRUITING

MeSH Terms

Interventions

Hyperbaric Oxygenation

Intervention Hierarchy (Ancestors)

Oxygen Inhalation Therapy; Respiratory Therapy; Therapeutics

Central Study Contacts

Eldad mr Yaakobi

CONTACT

972-8-9779393; yaakobi.eldad@gmail.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: QUADRUPLE
• Who Masked: PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
• Masking Details: the participants, investigators and outcome assessors will be blinded from the group allocation
• Purpose: TREATMENT
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Model Details: Eligible participants will be randomized to one of the study groups at a 1:1 ratio : Group-1: HYPEROXYGENATED ENVIRONMENT (HOE) first, SHAM second. Group-2: SHAM first, HYPEROXYGENATED ENVIRONMENT (HOE) second.

Study Record Dates

• First Submitted: April 16, 2026
• First Posted: April 30, 2026
• Study Start: January 1, 2024
• Primary Completion (Estimated): December 31, 2027
• Study Completion (Estimated): December 31, 2027
• Last Updated: April 30, 2026

Record last verified: 2026-04

Data Sharing

• IPD Sharing: Will not share

Locations

IL (1)