Measuring Brain Changes Following Cognitive Intervention in Pediatric Patients With Brain Tumors
1 other identifier
interventional
300
1 country
1
Brief Summary
The goal of this study is to learn if an online computerized training program improves processing speed in children with pediatric brain tumors. The main questions it aims to answer are:
- 1.Is the cognitive intervention feasible to administer to children with brain tumors during and after cancer treatment?
- 2.Is the cognitive intervention acceptable to patients and caregivers?
- 3.Does the cognitive intervention improve neuropsychological functioning?
- 4.Complete 15 minutes of online computerized cognitive training 5 times a week for 8 weeks.
- 5.Have weekly check-ins with the cognitive coach.
- 6.Fill out acceptability surveys at the end of the cognitive intervention.
- 7.Complete pre- and post- neuropsychological testing.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for not_applicable
Started May 2026
Longer than P75 for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
March 19, 2026
CompletedFirst Posted
Study publicly available on registry
April 30, 2026
CompletedStudy Start
First participant enrolled
May 6, 2026
CompletedPrimary Completion
Last participant's last visit for primary outcome
May 6, 2031
ExpectedStudy Completion
Last participant's last visit for all outcomes
April 1, 2033
May 5, 2026
May 1, 2026
5 years
March 19, 2026
May 4, 2026
Conditions
Keywords
Outcome Measures
Primary Outcomes (4)
Platform Engagement - Logins
Total number of logins recorded over the intervention period.
8 weeks
Platform Engagement - Task Completion
Total number of completed cognitive training levels
8 weeks
Engagement Barriers
Participant-reported engagement and barriers measured using a Likert-scale questionnaire administered weekly during the intervention. Mean total score will be reported. Qualitative feedback regarding barriers and facilitators to engagement will also be collected to provide descriptive context.
Weekly during 8-week intervention
Acceptability
Participant-reported acceptability measured using a Likert-scale questionnaire administered at the end of the intervention. Mean total score will be reported. Qualitative feedback regarding participant experience will also be collected to provide descriptive context.
Week 8
Secondary Outcomes (1)
Processing speed
Prior to the intervention, immediately following intervention, and 6 months after intervention completion.
Study Arms (1)
Cognitive Intervention
EXPERIMENTALComputerized cognitive training program focused on processing speed.
Interventions
This online cognitive intervention aims to improve processing speed through individualized, computerized cognitive exercises. A cognitive coach selects a set of cognitive exercises for each participant based on identified needs, cognitive ability, and age. Participants complete 15 minutes of training, 5 times per week for 8 weeks, for a target total of approximately 10 hours of training.
Eligibility Criteria
You may qualify if:
- Patients with a primary tumor located in the brain
- Diagnosed between 0 and 25 years of age
- Within five years of cancer diagnosis
- Receiving care at Johns Hopkins Hospital
You may not qualify if:
- Patients with a primary tumor outside of the brain
- Patients too young to participate in the cognitive intervention (\<5 years)
- Patients with severe brain injuries that precludes them from understanding and participating in the cognitive intervention
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Kennedy Krieger Institute
Baltimore, Maryland, 21205, United States
Related Publications (4)
Meneses K, Benz R, Bail JR, Vo JB, Triebel K, Fazeli P, Frank J, Vance DE. Speed of processing training in middle-aged and older breast cancer survivors (SOAR): results of a randomized controlled pilot. Breast Cancer Res Treat. 2018 Feb;168(1):259-267. doi: 10.1007/s10549-017-4564-2. Epub 2017 Nov 11.
PMID: 29128897BACKGROUNDMaeir T, Makranz C, Peretz T, Odem E, Tsabari S, Nahum M, Gilboa Y. Cognitive Retraining and Functional Treatment (CRAFT) for adults with cancer related cognitive impairment: a preliminary efficacy study. Support Care Cancer. 2023 Feb 7;31(3):152. doi: 10.1007/s00520-023-07611-y.
PMID: 36746805BACKGROUNDAreklett EW, Hagen BI, Stubberud J, Fagereng E, Andersson S, Lindemann K. Digital goal management training for cognitive impairment in cervical cancer survivors-a randomized comparison study. J Cancer Surviv. 2024 Nov 22. doi: 10.1007/s11764-024-01701-4. Online ahead of print.
PMID: 39576570BACKGROUNDJacola LM, Peterson RK, Oswald-McCloskey KA, Sekely A, Mabbott DJ, Edelstein K. Neuropsychological function in childhood cancer patients and adult survivors of childhood cancer. J Clin Exp Neuropsychol. 2025 Oct;47(8):788-805. doi: 10.1080/13803395.2025.2521018. Epub 2025 Jul 9.
PMID: 40635330BACKGROUND
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Rachel K Peterson, PhD
Hugo W. Moser Research Institute at Kennedy Krieger, Inc.
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- NA
- Masking
- NONE
- Purpose
- SUPPORTIVE CARE
- Intervention Model
- SINGLE GROUP
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
March 19, 2026
First Posted
April 30, 2026
Study Start
May 6, 2026
Primary Completion (Estimated)
May 6, 2031
Study Completion (Estimated)
April 1, 2033
Last Updated
May 5, 2026
Record last verified: 2026-05