NCT07558239

Brief Summary

  • Cardiovascular disease (CVD) is the leading cause of mortality in hemodialysis (HD) patients.
  • Carotid intima-media thickness (CIMT) is a validated surrogate marker for atherosclerosis.
  • Both traditional cardiovascular risk factors (hypertension, diabetes, dyslipidemia) and dialysis-specific factors (mineral metabolism disorders, dialysis duration) contribute to vascular damage.

Trial Health

65
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
100

participants targeted

Target at P50-P75 for all trials

Timeline
2mo left

Started Apr 2026

Shorter than P25 for all trials

Status
not yet recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress20%
Apr 2026Jul 2026

First Submitted

Initial submission to the registry

April 23, 2026

Completed
1 day until next milestone

Study Start

First participant enrolled

April 24, 2026

Completed
6 days until next milestone

First Posted

Study publicly available on registry

April 30, 2026

Completed
2 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

July 1, 2026

Expected
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

July 1, 2026

Last Updated

April 30, 2026

Status Verified

April 1, 2026

Enrollment Period

2 months

First QC Date

April 23, 2026

Last Update Submit

April 23, 2026

Conditions

HypertensionAtherosclerosisDialysis Patients

Keywords

Renal dialysisCarotid intima- media thickness

Outcome Measures

Primary Outcomes (1)

  • • To determine the association between carotid intima - media thickness and: o Hypertension duration o HbA1c o LDL/HDL ratio o Dialysis duration o Parathyroid hormone (PTH) levels

    6 month

Secondary Outcomes (1)

  • • To compare CIMT between: o Diabetics vs. non-diabetics o Short (<5 yrs) vs. long (≥5 yrs) dialysis duration o Patients with vs. without hyperparathyroidism (PTH >300 pg/m

    6month

Interventions

Ultrasound measurements of carotid intima- media thicknessOTHER

Ultrasound measurements of carotid intima- media thickness

Eligibility Criteria

Age18 Years - 70 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Renal dialysis patients

You may qualify if:

  • \. Age 18 or older. 2. Patients with sepsis without AKI at the time of admission.

You may not qualify if:

  • o Active malignancy
  • Acute infections
  • Recent cardiovascular events (\<3 months)
  • Poor echocardiographic window for CIMT measurement

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Related Publications (1)

  • https://doi.org/10.1016/j.atherosclerosis.2019.06.560

    BACKGROUND

MeSH Terms

Conditions

HypertensionAtherosclerosis

Condition Hierarchy (Ancestors)

Vascular DiseasesCardiovascular DiseasesArteriosclerosisArterial Occlusive Diseases

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Assistant professor

Study Record Dates

First Submitted

April 23, 2026

First Posted

April 30, 2026

Study Start

April 24, 2026

Primary Completion (Estimated)

July 1, 2026

Study Completion (Estimated)

July 1, 2026

Last Updated

April 30, 2026

Record last verified: 2026-04

Data Sharing

IPD Sharing
Will not share