Evaluating the Clinical Impact of the Prehabilitation and Recovery for Enabling Potential (PREP) Clinical Care Pathway

NCT07553806 | Not Yet Recruiting

• 1 other identifier: RL1 934
• Study Type: observational
• Target: 80
• Locations: 1 country
• Sites: 1

Brief Summary

The Evaluating PREP Study aims to determine in whether the PREP Programme has an impact on clinical outcomes for Veterans undergoing TKR. Specifically, we are exploring whether prehabilitation and a week long intense individualised rehabilitation period after TKR surgery has a positive impact on functional and mental outcomes, and whether these are sustained for up to 12 months post-surgery.

Conditions

Osteo Arthritis of the Knee

Keywords

Physiotherapy; Prehabilitation; Rehabilitation; Outcome

Outcome Measures

Primary Outcomes (1)

• Clinical impact using the Oxford Knee Score

  To evaluate the clinical impact, using the Oxford Knee Score, of the PREP Programme for Veterans up to 1 year following total knee replacement surgery. The Oxford Knee Score (OKS) is a 12-item patient-reported outcome measure (PROM) developed by the University of Oxford designed to assess knee pain and function, primarily in patients undergoing knee replacement surgery or managing knee osteoarthritis. Each question is scored 0-4, giving a total score from 0 (severe knee problems) to 48 (satisfactory joint function). Higher scores indicate better knee health.

  From time of total knee replacement, up to 12 months following surgery

Secondary Outcomes (4)

• Correlation of Baseline PANAS score and primary outcome - the Oxford Knee Score

  From baseline, up to 12 months post-surgery

• Correlation of Baseline PANAS score and the PROM - The Western Ontario and McMaster Universities Arthritis Index (WOMAC) Osteoarthritis Index

  From baseline to 12 months post surgery

• Incidences of manipulations under anaesthetic

  From surgery, up to and 12 months following TKR surgery.

• Practicality of delivering individualised prehabilitation and/or intensive post-operative rehabilitation

  From baseline, up to 12 months post-surgery

Study Arms (1)

Veterans undergoing total knee replacement

Investigation of whether prehabilitation and a week long intense individualised rehabilitation period after TKR surgery has a positive impact on functional and mental outcomes, and whether these are sustained for up to 12 months post-surgery.

Eligibility Criteria

• Age: 18 Years - 100 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Potential participants will be identified from clinic lists at the Veterans Orthopaedic Service, Robert Jones and Agnes Hunt Orthopaedic Hospital. Patients that are Veterans, that have been listed for a total knee replacement surgery at the hospital and also agreed to enter into the PREP clinical pathway programme will be eligible to take part in this research study.

You may qualify if:

• Age ≥ 18 years
• Must be a Veteran under the clinical care of an RJAH Veterans Orthopaedic Consultant and participating in the PREP Programme.
• Able to read and speak English.
• Able to demonstrate capacity to provide informed consent.

You may not qualify if:

• Subject is under 18 years of age.
• Subject is not a Veteran, not under the care of an RJAH Veteran's Orthopaedic Consultant, or is not participating in the PREP Programme.
• Unable to read and speak English.
• Unable to demonstrate capacity to provide informed consent.
• Unable, or unwilling to complete questionnaires throughout the duration of the study.

Sponsors & Collaborators

• Robert Jones and Agnes Hunt Orthopaedic and District NHS Trust: lead

Study Sites (1)

The Robert Jones and Agnes Hunt Orthopaedic Hospital

Oswestry, Shropshire, SY10 7AG, United Kingdom

Location

Central Study Contacts

Marit N Dugard, PhD

CONTACT

+44 1691 404139; naomi.dugard@nhs.net

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER GOV
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 8, 2026
• First Posted: April 28, 2026
• Study Start: May 1, 2026
• Primary Completion (Estimated): October 1, 2027
• Study Completion (Estimated): May 1, 2028
• Last Updated: May 4, 2026

Record last verified: 2026-04

Data Sharing

• IPD Sharing: Will not share

Locations

GB (1)