Hyperoxemia in the Intensive Care Unit(ICU)

NCT07549763 | Completed

• 1 other identifier: TÜTF-BAEK 2021/174
• Study Type: observational
• Target: 260
• Locations: 1 country
• Sites: 1

Brief Summary

In our study, to research the prevalence of hyperoxemia in adult patients treated in the intensive care unit (ICU) and its relationship with clinical outcomes. This single-center, observational study included 260 consecutive patients aged 18-85 years who received oxygen therapy in the ICU for respiratory failure. Hyperoxia was defined as SpO₂\>96% and PaO₂\>100 mmHg in the first 24 hours. Patients were divided into normoxic and hyperoxic groups, and demographic characteristics, comorbidities, ICU admission scores, mechanical ventilation requirements, ICU and hospital length of stay, and in-hospital mortality were compared.The mean age of the patients was 69.9±15.4 years, and 55.8% were male. According to SpO₂-PaO₂ criteria, hyperoxia was detected in 59.6% (n=155) of patients and normoxia in 40.4% (n=105). The groups were similar in terms of age, gender, BMI, and APACHE II score. The SOFA score and admission GCS were lower in the hyperoxic group, and the duration of mechanical ventilation, ICU, and hospital stays were significantly longer (p\<0.01 for all). In-hospital mortality was significantly higher in the hyperoxic group (82.5% vs. 50.4%; p\<0.001). In our study, hyperoxia developed in approximately two-thirds of the patients in the ICU, and hyperoxia was associated with increased mortality and length of stay. These results highlight the importance of avoiding hyperoxia when titrating oxygen therapy in critically ill patients.

Conditions

Hyperoxemia; Intensive Care Unit (ICU); CPAP; Mortality; Invasive Mechanical Ventilation

Keywords

hyperoxemia; intensive care unit

Outcome Measures

Primary Outcomes (1)

• In which treatment methods is more hyperoxia observed

  The incidence of hyperoxemia was compared in oxygen support therapies such as simple face masks, HFNO, and CPAP.

  through study completion, an average of 2 year

Study Arms (2)

hyperoxemia group

SpO2 \> %96 , PaO2\>100 mmHg

normoxemia group

SpO2:% 92-96 , PaO2: 60-100 mmHg

Eligibility Criteria

• Age: 18 Years - 85 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

The study included 260 patients aged 18-85 years who received non-invasive or invasive oxygen therapy for respiratory failure as indicated in the Surgical, Reanimation and Postoperative intensive care units of Trakya University Faculty of Medicine Hospital and who were found to have hyperoxia within the first 24 hours of treatment.

You may qualify if:

• Patients between the ages of 18-85
• Patients in the intensive care unit receiving non-invasive or invasive oxygen therapy due to respiratory failure
• Patients who develop hyperoxia within the first 24 hours of treatment

You may not qualify if:

• Patients who stayed in the intensive care unit for less than 24 hours
• Patients suspected of brain death
• Patients suspected of being pregnant

Sponsors & Collaborators

• Trakya University: lead

Study Sites (1)

Trakya Üniversitesi Tip Fakültesi

Edirne, Merkez, 22100, Turkey (Türkiye)

Location

Study Officials

• MEHMET TURAN İNAL

  Trakya University

  STUDY CHAIR

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: RESEARCH ASSISTANT DOCTOR

Study Record Dates

• First Submitted: April 13, 2026
• First Posted: April 24, 2026
• Study Start: June 1, 2021
• Primary Completion: December 31, 2023
• Study Completion: December 31, 2023
• Last Updated: April 24, 2026

Record last verified: 2026-04

Locations

TU (1)