Ozone Oil-based Gel and CHX Gel After Lower Third Molar Removal

NCT07549672 | Active Not Recruiting Early Phase 1 DMC FDA Drug

• 1 other identifier: 27623
• Study Type: interventional
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

Overall, 100 patients of both genders were included in the study, with indication of surgical extraction of lower third molar, positioned similarly after being clinically and radiographically checked by X-ray and orthopantomography. Each patient was subjected to both groups in separate sessions: treated with ozone gas and with CHX gel 1%. Data on pain intensity, number of taken analgesics- painkillers, and dry socket were recorded for 48 h and at Day 7

Conditions

Pain; Dry Socket

Keywords

Dry socket; Pain; Lower third molar

Outcome Measures

Primary Outcomes (1)

• pain severity

  pain scale ( VAS ; visual analogue scale) (1-10)

  7 days

Secondary Outcomes (1)

• dry socket incidence

  15 daays

Study Arms (1)

study group and control group

EXPERIMENTAL

study group

Drug: Ozone Oil-based Gel

Interventions

Ozone Oil-based Gel DRUG

Overall, 30 patients of both genders were included in the study, with indication of surgical extraction of lower third molar, positioned similarly after being clinically and radiographically checked by X-ray and orthopantomography. Each patient was subjected to both groups in separate sessions: treated with ozone gas and with CHX gel 1%. Data on pain intensity, number of taken analgesics- painkillers, and dry socket were recorded for 48 h and at Day 7

Also known as: CHX Gel

study group and control group

Eligibility Criteria

• Age: 21 Years - 35 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Patients with third impacted bilateral molars, symmetrically in the same position, position evaluated by radiography.
• Patients in whom operative extraction of third molars is indicated with the creation of a mucoperiosteal flap.
• Patients regardless of gender.

You may not qualify if:

• lack of cooperation in any of the work phase

Sponsors & Collaborators

• Cairo University: lead

Study Sites (1)

ASSOCIATE PROFESSOR cairo university

Cairo, Cairo Governorate, 12515, Egypt

Location

MeSH Terms

Conditions

Pain; Dry Socket

Condition Hierarchy (Ancestors)

Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Mouth Diseases; Stomatognathic Diseases

Study Design

• Study Type: interventional
• Phase: early phase 1
• Allocation: NA
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: associate professor of oral and maxillofacial surgery

Model Details: Overall, 100 patients of both genders were included in the study, with indication of surgical extraction of lower third molar, positioned similarly after being clinically and radiographically checked by X-ray and orthopantomography. Each patient was subjected to both groups in separate sessions: treated with ozone gas and with CHX gel 1%. Data on pain intensity, number of taken analgesics- painkillers, and dry socket were recorded for 48 h and at Day 7

Study Record Dates

• First Submitted: April 9, 2026
• First Posted: April 24, 2026
• Study Start: July 1, 2023
• Primary Completion (Estimated): August 1, 2026
• Study Completion (Estimated): September 1, 2026
• Last Updated: April 28, 2026

Record last verified: 2026-04

Data Sharing

• IPD Sharing: Will not share

Locations

EG (1)