Postoperative Analgesia and Recovery Quality in Total Thyroidectomy

NCT07547124 | Not Yet Recruiting

• 1 other identifier: Serpil Tiroid
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

This prospective observational study evaluates the association between postoperative analgesic approaches and recovery outcomes in patients undergoing elective total thyroidectomy. Patients will be followed under routine clinical care without intervention or randomization. The primary outcome is the Quality of Recovery-15 (QoR-15) score at 24 hours. Secondary outcomes include swallowing pain, resting pain, opioid consumption, postoperative nausea and vomiting, and additional analgesic requirement.

Conditions

Postoperative Pain

Outcome Measures

Primary Outcomes (1)

• Quality of Recovery-15 (QoR-15) Total Score

  Quality of recovery will be assessed using the QoR-15 questionnaire. The total score ranges from 0 to 150, with higher scores indicating better recovery. The outcome will be compared between patients who received cervical plexus block and those who did not.

  24 hours postoperatively

Study Arms (2)

Cervical Plexus Block Group

Patients who receive bilateral intermediate cervical plexus block as part of routine clinical practice, based on the attending anesthesiologist's decision.

No Block Group

Patients who do not receive cervical plexus block and are managed with standard postoperative analgesia according to routine clinical practice.

Other: Cervical Plexus Block

Interventions

Cervical Plexus Block OTHER

Bilateral intermediate cervical plexus block may be performed as part of routine clinical practice based on the attending anesthesiologist's decision. The study is observational, and no intervention, assignment, or protocol-driven procedure is applied. Patients are managed according to standard perioperative care.

No Block Group

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adults aged 18-75 years with ASA physical status I-III scheduled for elective bilateral total thyroidectomy under general anesthesia. Participants must be cognitively able to read Turkish and complete the QoR-15 questionnaire and provide written informed consent. Patients with chronic opioid use, chronic pain syndromes, psychiatric or neurological disorders, previous cervical surgery, planned extensive surgery, emergency procedures, pregnancy, or expected postoperative ICU need are excluded.

You may qualify if:

• Patients aged 18-75 years
• ASA physical status classification I-III
• Patients scheduled for elective bilateral total thyroidectomy
• Patients undergoing surgery under general anesthesia
• Individuals able to read and understand Turkish and cognitively capable of completing the QoR-15 questionnaire
• Patients providing written informed consent to participate in the study

You may not qualify if:

• Chronic opioid use (≥3 months of regular opioid use)
• Presence of chronic pain syndrome
• Psychiatric illness or cognitive impairment
• History of neurological disease (stroke, dementia, Parkinson's disease, etc.)
• Known allergy to local anesthetic agents
• Previous surgical interventions in the cervical region (including revision thyroid surgery)
• Planned extended surgery with concomitant neck dissection
• Substernal/retrosternal goiter cases (with potential need for sternotomy or additional procedures)
• Emergency surgical procedures
• Patients with ASA physical status IV or higher
• Pregnancy
• Patients expected to require postoperative intensive care
• Patients experiencing intraoperative complications that deviate from the standard monitoring protocol

Sponsors & Collaborators

• Istinye University: lead

Study Sites (1)

Istinye Üniversity

Istanbul, Merkez Mahallesi, 34250, Turkey (Türkiye)

Location

Related Publications (2)

• Wilson L, Malhotra R, Mayhew D, Banerjee A. The analgesic effects of bilateral superficial cervical plexus block in thyroid surgery: A systematic review and meta-analysis. Indian J Anaesth. 2023 Jul;67(7):579-589. doi: 10.4103/ija.ija_806_22. Epub 2023 Jul 14.

  PMID: 37601928 RESULT

• Mostafa MM, Gamal RM, Ahmed Baiomy AM, Hassan ME, Kamal JM, Ts T, Kotb TA, Elrawas MM. Efficacy of adding dexmedetomidine as adjuvant with bupivacaine in ultrasound-guided intermediate cervical plexus block for thyroidectomy surgery: randomized controlled study. BMC Anesthesiol. 2025 Mar 25;25(1):139. doi: 10.1186/s12871-025-02990-7.

  PMID: 40133795 RESULT

MeSH Terms

Conditions

Pain, Postoperative

Interventions

Cervical Plexus Block

Condition Hierarchy (Ancestors)

Postoperative Complications; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Pain; Neurologic Manifestations; Signs and Symptoms

Intervention Hierarchy (Ancestors)

Nerve Block; Anesthesia, Conduction; Anesthesia; Anesthesia and Analgesia

Central Study Contacts

İlke Dolgun

CONTACT

05555485632; ilkeser2004@gmail.com

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assoc.Prof

Study Record Dates

• First Submitted: April 2, 2026
• First Posted: April 23, 2026
• Study Start: April 10, 2026
• Primary Completion (Estimated): August 10, 2026
• Study Completion (Estimated): September 10, 2026
• Last Updated: April 23, 2026

Record last verified: 2026-04

Locations

TU (1)