NCT07546357

Brief Summary

The objective of this project is to define and test the GenAI-powered Clinical Decision Support (CDS) tool, AIManage, providing a broad range of incretin mimetic medication management services to optimize dose titrations. The study will take place across primary care and obesity medicine clinics at NYUH. The study is currently conducting formative data collection for tool refinement (Phase 1). Once completed, a cluster randomized controlled trial of the AIManage tool will be undertaken (Phase 2).

Trial Health

63
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
16

participants targeted

Target at below P25 for not_applicable diabetes

Timeline
34mo left

Started Jun 2026

Typical duration for not_applicable diabetes

Geographic Reach
1 country

1 active site

Status
not yet recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

April 10, 2026

Completed
12 days until next milestone

First Posted

Study publicly available on registry

April 22, 2026

Completed
1 month until next milestone

Study Start

First participant enrolled

June 1, 2026

Expected
1.8 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

March 30, 2028

1 year until next milestone

Study Completion

Last participant's last visit for all outcomes

March 30, 2029

Last Updated

April 22, 2026

Status Verified

April 1, 2026

Enrollment Period

1.8 years

First QC Date

April 10, 2026

Last Update Submit

April 16, 2026

Conditions

Keywords

GLP-1Incretin mimeticmedication managementside effect management

Outcome Measures

Primary Outcomes (4)

  • Percentage of Patients who Complete Qualitative Measure - Perceived Usefulness

    In Phase 1, qualitative data regarding perceived usefulness will be collected.

    Day 1 (60 minutes)

  • Percentage of Patients who Complete Qualitative Measure - Perceived Usability

    In Phase 1, qualitative data regarding perceived usability will be collected.

    Day 1 (60 minutes)

  • Percentage of Patients who Complete Qualitative Measure - Perceived Use Challenges

    In Phase 1, qualitative data regarding perceived use challenges will be collected.

    Day 1 (60 minutes)

  • Percentage of Patients who Complete Qualitative Measure - Perceived Value

    In Phase 1, qualitative data regarding perceived value will be collected.

    Day 1 (60 minutes)

Study Arms (2)

Providers (Phase 1)

EXPERIMENTAL

Providers prescribing IMM for at least 5 adult patients in primary care and obesity medicine clinics.

Other: AIManage

Patients (Phase 1)

EXPERIMENTAL

Adult patients prescribed an IMM in the past 6 months.

Other: AIManage

Interventions

GenAI-powered CDS tool that provides a range of IMM management services, such as personalized guidance for patients on side effects management and clinical advisement to optimize dose titrations.

Patients (Phase 1)Providers (Phase 1)

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Provider Eligibility Criteria (Phase 1)
  • Primary or bariatric care provider (MD/DO, NP) practicing at the participating NYULH clinics,
  • Provide care to at least 5 patients prescribed an IMM.
  • Patient Eligibility Criteria (Phase 1)
  • (Phase 1) Currently taking an IMM or have taken an IMM in the past 6 months;
  • Fluency in English or Spanish;
  • Be willing to send/receive text messages; and
  • Be \> 18 years of age.

You may not qualify if:

  • Refuse or are unable to provide informed consent;

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

NYU Langone Health

New York, New York, 10016, United States

Location

MeSH Terms

Conditions

Diabetes MellitusObesityDrug-Related Side Effects and Adverse Reactions

Condition Hierarchy (Ancestors)

Glucose Metabolism DisordersMetabolic DiseasesNutritional and Metabolic DiseasesEndocrine System DiseasesOverweightOvernutritionNutrition DisordersBody WeightSigns and SymptomsPathological Conditions, Signs and SymptomsChemically-Induced Disorders

Study Officials

  • Elizabeth Stevens, PhD, MPH

    NYU Langone Health

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Elizabeth Stevens, PhD, MPH

CONTACT

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NON RANDOMIZED
Masking
NONE
Purpose
OTHER
Intervention Model
SINGLE GROUP
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

April 10, 2026

First Posted

April 22, 2026

Study Start (Estimated)

June 1, 2026

Primary Completion (Estimated)

March 30, 2028

Study Completion (Estimated)

March 30, 2029

Last Updated

April 22, 2026

Record last verified: 2026-04

Data Sharing

IPD Sharing
Will share

The de-identified participant data from the final research dataset will be shared upon reasonable request beginning 9 to 36 months after publication or as required by a condition of awards or supporting agreements, provided the requesting investigator executes a data use agreement with NYU Langone Health. This instance of data sharing will also require separate IRB review as well as review from NYU Langone's Data Sharing Strategy Board (DSSB). Requests should be directed to: Elizabeth.Stevens@nyulangone.org. The protocol and statistical analysis plan will be posted on Clinicaltrials.gov only as required by federal regulation or supporting awards and agreements.

Shared Documents
STUDY PROTOCOL, SAP
Time Frame
Beginning 9 months and ending 36 months following article publication or as required by a condition of awards and agreements supporting the research
Access Criteria
The investigator who proposed to use the data will be granted access upon reasonable request. Requests should be directed to Elizabeth.Stevens@nyulangone.org. To gain access, data requestors will need to sign a data access agreement. This instance of data sharing will also require separate IRB review as well as review from NYU Langone's DSSB.

Locations