Effect of Lateral Versus Supine Positions on Postoperative Hypoxemia

NCT07545642 | Recruiting

• 1 other identifier: dywe0001
• Study Type: interventional
• Target: 960
• Locations: 1 country
• Sites: 1

Brief Summary

Using prospective real-world data, this study aims to determine whether the lateral decubitus position reduces the incidence of post-procedure hypoxemia in patients undergoing painless gastroscopy/colonoscopy, thereby providing a simple, non-invasive, and low-cost optimization strategy for clinical practice.

Conditions

Postoperative Hypoxemia

Outcome Measures

Primary Outcomes (1)

• Incidence of recovery-phase hypoxemia,

  Proportion of participants experiencing hypoxemia (SpO₂ ≤ 90% lasting \>10 seconds) during the post-procedure recovery period.

  From PACU admission until discharge, assessed up to 30 minutes

Secondary Outcomes (12)

• Incidence of Subclinical Respiratory Depression during Recovery

  From PACU admission until discharge, assessed up to 30 minutes.

• Incidence of Severe Hypoxemia During Recovery

  From PACU admission until discharge, assessed up to 30 minutes

• Overall Incidence of Airway Intervention During Recovery

  From PACU admission until discharge, assessed up to 30 minutes

• Cough Severity Grade During Recovery

  From PACU admission until discharge, assessed up to 30 minutes

• Length of Stay in Post-Anesthesia Care Unit (PACU)

  From PACU admission until discharge

Other Outcomes (1)

• Prespecified Subgroup Analyses

  From PACU admission until discharge, assessed up to 30 minutes

Study Arms (2)

Supine position group (Group S)

EXPERIMENTAL

The patient was turned from the predetermined left lateral position to the supine position without a head pillow (head-of-bed elevation at 0 degrees）

Procedure: Supine position group (Group S)

Lateral decubitus position group (Group L)

EXPERIMENTAL

Upon arrival in the post-anesthesia care unit (PACU), the patient was kept in the left lateral decubitus position

Procedure: Lateral decubitus position group (Group L)

Interventions

Lateral decubitus position group (Group L) PROCEDURE

Upon admission to the Post-Anesthesia Care Unit (PACU), an independent researcher (attending anesthesiologist) assessed the patient using the Ramsay Sedation Scale (1: anxious and agitated; 2: awake, calm, and cooperative; 3: drowsy but responsive to verbal commands; 4: asleep but responsive to tactile stimulation or pain; 5: asleep with a sluggish response to stimulation; 6: deep sleep with no response). Patients in the Lateral Group (Group L) were maintained in the predetermined left lateral position. Standard monitoring was applied, and nasal cannula oxygen was administered at 2 L/min. If SpO₂ remained \>95% for at least 5 minutes, oxygen was discontinued for observation. To ensure strict adherence to the protocol, an independent researcher continuously monitored and verified patient positioning (corrections were made only if the patient rolled unconsciously). Patients were evaluated using the Aldrete discharge scoring system; discharge from the PACU occurred when a score of \>9 was a

Lateral decubitus position group (Group L)

Supine position group (Group S) PROCEDURE

Upon admission to the Post-Anesthesia Care Unit (PACU), an independent researcher (attending anesthesiologist) assessed the patient using the Ramsay Sedation Scale (1: anxious and agitated; 2: awake, calm, and cooperative; 3: drowsy but responsive to verbal commands; 4: asleep but responsive to tactile stimulation or pain; 5: asleep with a sluggish response to stimulation; 6: deep sleep with no response). Patients in the Supine Group (Group S) were turned from the predetermined lateral position to the supine position without a head pillow (head-of-bed elevation at 0 degrees). Standard monitoring was applied, and nasal cannula oxygen was administered at 2 L/min. If SpO₂ remained \>95% for at least 5 minutes, oxygen was discontinued for observation. To ensure strict adherence to the protocol, an independent researcher continuously monitored and verified patient positioning (corrections were made only if the patient rolled unconsciously). Patients were evaluated using the Aldrete discharge

Supine position group (Group S)

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Age ≥ 18 years.
• Both sexes.
• American Society of Anesthesiologists (ASA) physical status classification I-III.
• Scheduled for combined painless esophagogastroduodenoscopy/colonoscopy or either of the two procedures.
• Ability to understand the study protocol and provide written informed consent.

You may not qualify if:

• Severe cardiovascular or cerebrovascular diseases.
• Pregnant patients.
• History of hypersensitivity to ciprofol.
• Withdrawal Criteria:
• Endotracheal intubation required during the procedure.
• Voluntary withdrawal requested by the patient or their legal representative.

Sponsors & Collaborators

• General Hospital of Ningxia Medical University: lead

Study Sites (1)

General hospital of Ningxia medical university, Yinchuan, Ningxia

Yinchuan, Ningxia, 750001, China

RECRUITING

Study Officials

• Xinli Ni, Doctoral

  86-951-674-3252

  STUDY CHAIR

Central Study Contacts

Xiaoyong Wei, Degree

CONTACT

86-951-674-3252; weixy9912@126.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Masking Details: Random sequence generation was performed by an independent statistician using computer-generated codes. Allocation concealment was maintained using sequentially numbered, opaque, sealed envelopes (SNOSE), which were opened immediately prior to intervention implementation. Due to the nature of the intervention (body positioning), blinding of participants and personnel was not feasible; however, outcome assessors were blinded, and objective outcome measures were utilized to minimize detection bias."
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 7, 2026
• First Posted: April 22, 2026
• Study Start: April 23, 2026
• Primary Completion (Estimated): June 20, 2026
• Study Completion (Estimated): June 30, 2026
• Last Updated: April 22, 2026

Record last verified: 2026-04

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)