Effect of Postural Changes on Postoperative Hypoxemia

NCT07161817 | Not Yet Recruiting DMC

• 1 other identifier: Postoperative Hypoxemia
• Study Type: interventional
• Target: 1,200
• Locations: 0 countries
• Sites: N/A

Brief Summary

The goal of this clinical trial is to learn which positioning strategy works better to prevent postoperative hypoxemia in surgical patients: semirecumbent positioning or lateral positioning. It will also learn about the safety and effectiveness of these two positioning approaches. The main questions it aims to answer are: Does semirecumbent positioning reduce the incidence of postoperative hypoxemia more effectively than lateral positioning? Does lateral positioning reduce the incidence of postoperative hypoxemia more effectively than semirecumbent positioning? What are the differences in patient comfort and recovery outcomes between these two positioning strategies? Researchers will compare semirecumbent positioning directly to lateral positioning to see which approach is more effective in preventing postoperative hypoxemia. Participants will: Be randomly assigned to either semirecumbent positioning or lateral positioning after surgery Have their oxygen levels and breathing monitored regularly during the postoperative period Receive standard post-surgical care with their assigned positioning strategy Be assessed for comfort levels and any positioning-related complications Have their recovery progress tracked throughout their hospital stay.

Conditions

Position Differences; Postoperative Hypoxemia

Keywords

Lateral positioning; Hypoxemia; Semirecumbent positioning

Outcome Measures

Primary Outcomes (1)

• Incidence of hypoxaemia

  Defined as any occurrence of oxygen saturation (SpO2) ≤90% for at least five seconds during the initial 10 minute period after positioning.

  Within 24 hours after the surgery was completed

Secondary Outcomes (6)

• Rrequency of airway rescue interventions

  Within 24 hours after the surgery was completed

• incidence of severe hypoxaemia

  Within 24 hours after the surgery was completed

• Lowest oxygen saturation

  Within 24 hours after the surgery was completed

• Duration of stay in the post-anaesthesia care

  Perioperative/Periprocedural

• wound pain

  Perioperative/Periprocedural

Study Arms (2)

Semirecumbent positioning

EXPERIMENTAL

Patients in the Semirecumbent positioning were placed in the bed and the head of the bed was raised by 30 °, allowing flexibility based on patient comfort and surgical requirements.

Behavioral: Semirecumbent positioning

Lateral positioning

EXPERIMENTAL

Patients allocated to lateral positioning were placed at 90° on a horizontal bed, supported with a pillow to maintain neutral alignment of the spine and avoid hyperextension or forward flexion of the neck. No preference was specified for left or right lateral decubitus positioning, allowing flexibility based on patient comfort and surgical requirements.

Behavioral: Lateral positioning

Interventions

Semirecumbent positioning BEHAVIORAL

Patients in the semi-recumbent position were placed in the bed and the head of the bed was raised by 30 °, allowing flexibility based on patient comfort and surgical requirements.

Semirecumbent positioning

Lateral positioning BEHAVIORAL

Patients allocated to lateral positioning were placed at 90° on a horizontal bed, supported with a pillow to maintain neutral alignment of the spine and avoid hyperextension or forward flexion of the neck. No preference was specified for left or right lateral decubitus positioning, allowing flexibility based on patient comfort and surgical requirements.

Lateral positioning

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Patients aged 18 or above and 80 or below who received general anesthesia and intubation

You may not qualify if:

• \- Patients aged 18 years and above, and 80 years and below, who received general anesthesia and intubation;
• Presence of hypotension or bradycardia upon entering the anesthesia recovery room;
• Preoperative hypoxemia;
• Surgical procedures where body position adjustment is not possible or is prohibited due to the nature of the surgery;
• Surgical procedures involving severe cardiovascular or cerebrovascular diseases, severe pulmonary diseases, intracranial hypertension, etc.;
• Intubation more than 3 times.

Sponsors & Collaborators

• Yuhu Ma: lead

Related Publications (2)

• Wang X, Guo K, Sun J, Yang Y, Wu Y, Tang X, Xu Y, Chen Q, Zeng S, Wang L, Liu S. Semirecumbent Positioning During Anesthesia Recovery and Postoperative Hypoxemia: A Randomized Clinical Trial. JAMA Netw Open. 2024 Jun 3;7(6):e2416797. doi: 10.1001/jamanetworkopen.2024.16797.

  PMID: 38941098 RESULT

• Ye H, Chu LH, Xie GH, Hua YJ, Lou Y, Wang QH, Xu ZX, Tang MY, Wang BD, Hu HY, Ying J, Yu T, Wang HY, Wang Y, Ye ZJ, Bao XF, Wang MC, Chen LY, Wang XX, Zhang XB, Huang CS, Wang J, Lu YP, Luo FQ, Zhou W, Wang CG, Cheng H, Liu WJ, Luo J, Wu YQ, Li RR, Wang D, Hou LQ, Shi L, Zhang J, Wang K, Pi X, Zhou R, Yang QQ, Wan PL, Li H, Wu SJ, Song SW, Cui P, Shu L, Islam N, Fang XM. Effect of lateral versus supine positioning on hypoxaemia in sedated adults: multicentre randomised controlled trial. BMJ. 2025 Aug 19;390:e084539. doi: 10.1136/bmj-2025-084539.

  PMID: 40829895 RESULT

MeSH Terms

Conditions

Hypoxia

Condition Hierarchy (Ancestors)

Signs and Symptoms, Respiratory; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Yatao Liu, Doctor

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Yuhu Ma, Master

CONTACT

18419379740; mayh20@lzu.edu.cn

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Doctor

Study Record Dates

• First Submitted: August 23, 2025
• First Posted: September 9, 2025
• Study Start: February 1, 2026
• Primary Completion (Estimated): October 1, 2027
• Study Completion (Estimated): October 1, 2028
• Last Updated: January 14, 2026

Record last verified: 2026-01

Data Sharing

• IPD Sharing: Will not share